{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:33:05Z","timestamp":1776781985372,"version":"3.51.2"},"reference-count":50,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009053","name":"DBT India Alliance","doi-asserted-by":"publisher","award":["501501"],"award-info":[{"award-number":["501501"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005918","name":"Christian Medical College, Vellore","doi-asserted-by":"publisher","award":["8962"],"award-info":[{"award-number":["8962"]}],"id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    IgA nephropathy (IgAN) is the most common primary glomerulonephritis and an important cause of end-stage kidney disease. Unlike the slowly progressive course seen among Caucasian and East Asian subjects (actuarial survival 80-85% over 10 years), in India about 30-40% of patients have nephrotic syndrome and renal dysfunction at presentation and a 10-year renal survival of 35%, as reported from a retrospective registry. These observations cannot be entirely attributed to a lack of uniform screening protocols or late referral and attest to the probability that IgAN may not be the same disease in different parts of the world.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    We will prospectively recruit 200 patients with IgAN (the GRACE IgANI\u2014\n                    <ns4:bold>G<\/ns4:bold>\n                    lomerular\n                    <ns4:bold>R<\/ns4:bold>\n                    esearch\n                    <ns4:bold>A<\/ns4:bold>\n                    nd\n                    <ns4:bold>C<\/ns4:bold>\n                    linical\n                    <ns4:bold>E<\/ns4:bold>\n                    xperiments-\n                    <ns4:bold>I<\/ns4:bold>\n                    g\n                    <ns4:bold>A<\/ns4:bold>\n                    <ns4:bold>N<\/ns4:bold>\n                    ephropathy in\n                    <ns4:bold>I<\/ns4:bold>\n                    ndians\u2014cohort) and stratify them into low and high risk of progression based on published absolute renal risk scores. We will test the validity of this risk score in an unselected Indian IgAN population over a 5-year follow-up period. In parallel, we will undertake extensive exploratory serum, urine, renal and microbiome biomarker studies, firstly, to determine if the underlying pathogenic pathways are the same in Indian IgAN compared to those reported in Caucasian and East Asian IgAN. Secondly, we will systematically assess the value of measuring selected biomarkers and adding this data to traditional measures of risk in IgAN to predict kidney failure. We ultimately hope to generate a composite IgAN risk score specific for the Indian population.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Ethics and data dissemination:<\/ns4:bold>\n                    Approval was obtained from the Institutional Review Board (Silver, Research and Ethics Committee) of the Christian Medical College, Vellore, India (Ref. No. IRB Min. No. 8962 [Other] dated 23.07.2014 and IRB Min. No. 9481 [Other] dated 24.06.2015). It is anticipated that results of this study will be presented at national and international meetings, with reports being published from late 2018.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.14644.1","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T14:00:46Z","timestamp":1532613646000},"page":"91","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Protocol and rationale for the first South Asian 5-year prospective longitudinal observational cohort study and biomarker evaluation investigating the clinical course and risk profile of IgA nephropathy: GRACE IgANI cohort"],"prefix":"10.12688","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-606X","authenticated-orcid":false,"given":"Suceena","family":"Alexander","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anila","family":"Korula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinoi George","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna T.","family":"Valson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibu","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep Mathew","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elenjickal Elias","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-987X","authenticated-orcid":false,"given":"Smita Mary","family":"Matthai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jeyaseelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babu","family":"Ponnusamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Pusey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed R.","family":"Daha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Feehally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-7229","authenticated-orcid":false,"given":"Jonathan","family":"Barratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Varughese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"ref-1","first-page":"142-4","article-title":"Long term follow up of patients with IgA nephropathy.","volume":"107","author":"R Bailey","year":"1994","journal-title":"N Z Med J."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"12-9","DOI":"10.1016\/S0272-6386(12)80284-8","article-title":"Prognostic factors in mesangial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses.","volume":"18","author":"E Alamartine","year":"1991","journal-title":"Am J Kidney Dis."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"437-50","DOI":"10.1159\/000168167","article-title":"Glomerular diseases in the tropics.","volume":"10","author":"K Chugh","year":"1990","journal-title":"Am J Nephrol."},{"key":"ref-4","first-page":"205-10","article-title":"Characterization of kidney lesions in Indian adults: towards a renal biopsy registry.","volume":"19","author":"B Narasimhan","year":"2006","journal-title":"J Nephrol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"250-7","DOI":"10.4103\/0971-4065.85482","article-title":"Pattern of biopsy-proven renal disease in a single center of south India: 19 years experience.","volume":"21","author":"U Das","year":"2011","journal-title":"Indian J Nephrol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"205-13","DOI":"10.1159\/000045404","article-title":"Nationwide and long-term survey of primary glomerulonephritis in Japan as observed in 1,850 biopsied cases. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.15946.r33586, Evangeline Pillebout, INSERM 1149, Center of Research on Inflammation, Paris, France, 08 Aug 2018, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/3-91\/v1#referee-response-33586","order":0,"name":"referee-response-33586","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.15946.r33587, Colin C. Geddes, The Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK, 19 Sep 2018, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/3-91\/v1#referee-response-33587","order":1,"name":"referee-response-33587","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work is supported by the Wellcome Trust\/DBT India Alliance Fellowship (grant number 501501). S.A. is a Wellcome Trust\/DBT India Alliance Early Career Fellow (Clinical and Public Health). Initial small funding was by a major fluid research internal grant [8962 (Other) dated 23.07.2014] from Christian Medical College, Vellore-632004, India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}