{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:08:05Z","timestamp":1790359685128,"version":"4.1.0"},"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Erasmus Mundus program - ERAWEB","award":["D2.12.048"],"award-info":[{"award-number":["D2.12.048"]}]},{"name":"Department of Health","award":["HICF-T2-0510-007"],"award-info":[{"award-number":["HICF-T2-0510-007"]}]},{"name":"Wellcome Trust","award":["WT094947"],"award-info":[{"award-number":["WT094947"]}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"\n Background:<\/ns4:bold>\n Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity. The WOMAN trial showed that tranexamic acid (TXA) reduces death due to bleeding in women with PPH. To determine whether TXA has pro-thrombotic effects in women with PPH, we measured endogenous thrombin potential (ETP), coagulation factors V, VIII, von Willebrand (vW), fibrinogen, D-Dimers and platelet function.\n <\/ns4:p>\n \n Methods<\/ns4:bold>\n : We conducted a sub-study within the WOMAN trial, an international randomized, parallel-group, double blind, placebo-controlled trial. Women with primary PPH were randomly allocated to receive 1 gram of tranexamic acid or matching placebo. Baseline blood samples were collected just prior to the first dose and a follow up sample was collected 30\u00b115 minutes afterwards. We compared before and after changes in coagulation parameters between treatment groups using repeated measurement ANOVA. Change in ETP was the primary outcome. We did an intention-to-treat analysis using ANCOVA with adjustment for baseline and the time interval between the blood samples.\n <\/ns4:p>\n \n Findings:<\/ns4:bold>\n A total of 187 patients were randomized to receive TXA (n=93) or matching placebo (n=94). Six patients were excluded due to incomplete data. The reduction in ETP from baseline to follow up was 43.2 nM*min (95%CI, -16.6 to 103.1) in the TXA group and 4.6 nM*min (95%CI, -51.4 to 60.6) in the placebo group. The difference was not statistically significant (95%CI, -42.9 to 120). There were no significant effects of TXA treatment on any other parameters (ADPtest, TRAPtest, coagulation factors activity, fibrinogen levels, D-Dimer level).\n <\/ns4:p>\n \n Conclusion:<\/ns4:bold>\n We found no evidence that tranexamic acid treatment for PPH has substantial pro-coagulant effects. However, larger studies are needed to confirm or refute more modest effects.\n <\/ns4:p>\n \n Trial registration:<\/ns4:bold>\n ISRCTN76912190<\/ns4:ext-link>\n (initially registered 10\/12\/2008, WOMAN-ETAPlat included on 28\/10\/2013) and\n NCT00872469<\/ns4:ext-link>\n (initially registered 31\/03\/2009, WOMAN-ETAPlat included on 28\/10\/2013).\n <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.14977.1","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T06:10:12Z","timestamp":1549347012000},"page":"21","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial"],"prefix":"10.12688","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-9438","authenticated-orcid":false,"given":"Kastriot","family":"Dallaku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6511-109X","authenticated-orcid":false,"given":"Haleema","family":"Shakur-Still","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Beaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-6054","authenticated-orcid":false,"given":"Ian","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaya","family":"Huque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-5241","authenticated-orcid":false,"given":"Maria","family":"Delius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Holdenrieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orion","family":"Gliozheni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Mansmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"w14551","DOI":"10.4414\/smw.2017.14551","article-title":"Temporal 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[Internet] LSHTM Data Compass","author":"K Dallaku","year":"2018"},{"key":"ref-29","article-title":"CONSORT statement"}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T18:09:40Z","timestamp":1589998180000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":29,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.14977.1","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.16336.r35666","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16336.r34770","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16336.r35666","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16336.r34770","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.16336.r34770, Anne-Sophie Ducloy-Bouthors, Tournoys Antoine, French Society\u00a0of Anesthesia\u00a0and\u00a0Resuscitation\u00a0(SFAR), Paris, France, 15 Feb 2019, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1#referee-response-34770","order":0,"name":"referee-response-34770","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.16336.r35666, Homa K. Ahmadzia, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA, 04 Jun 2019, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-21\/v1#referee-response-35666","order":1,"name":"referee-response-35666","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The WOMAN Trial was funded by the Department of Health (UK), grant number HICF-T2-0510-007, the Wellcome Trust, grant number WT094947, the Bill & Melinda Gates Foundation (grant number OPP1095618), and LSHTM (London, UK). An educational grant was given by Erasmus Mundus program ERAWEB [D2.12.048] and Rudolf Marx Foundation (Munich, Germany). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}