{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:26Z","timestamp":1772169146668,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.15060.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000}}],"reference-count":26,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M006727\/1"],"award-info":[{"award-number":["MR\/M006727\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["102215\/2\/13\/2"],"award-info":[{"award-number":["102215\/2\/13\/2"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["109104"],"award-info":[{"award-number":["109104"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Council","award":["MC_UU_12013\/1"],"award-info":[{"award-number":["MC_UU_12013\/1"]}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns5:p>\n                    <ns5:bold>Background:<\/ns5:bold>\n                    Sleep abnormalities are common in schizophrenia, often appearing before psychosis onset; however, the mechanisms behind this are uncertain. We investigated whether genetic risk for schizophrenia is associated with sleep phenotypes.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Methods:<\/ns5:bold>\n                    We used data from 6,058 children and 2,302 mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC). We examined associations between a polygenic risk score for schizophrenia and sleep duration in both children and mothers, and nightmares in children, along with genetic covariances between these traits.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Results:<\/ns5:bold>\n                    Polygenic risk for schizophrenia was associated with increased risk of nightmares (OR=1.07, 95% CI: 1.01, 1.14, p=0.02) in children, and also with less sleep (\u03b2=-44.52, 95% CI: \u221288.98, \u22120.07; p=0.05). We observed a similar relationship with sleep duration in mothers, although evidence was much weaker (p=0.38). Finally, we found evidence of genetic covariance between schizophrenia risk and reduced sleep duration in children and mothers, and between schizophrenia risk and nightmares in children.\n                  <\/ns5:p>\n                  <ns5:p>\n                    <ns5:bold>Conclusions:<\/ns5:bold>\n                    These molecular genetic results support recent findings from twin analysis that show genetic overlap between sleep disturbances and psychotic-like experiences. They also show, to our knowledge for the first time, a genetic correlation between schizophrenia liability and risk of nightmares in childhood.\n                  <\/ns5:p>","DOI":"10.12688\/wellcomeopenres.15060.2","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T10:13:17Z","timestamp":1566295997000},"page":"15","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Schizophrenia liability shares common molecular genetic risk factors with sleep duration and nightmares in childhood"],"prefix":"10.12688","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-6979","authenticated-orcid":false,"given":"Zoe E.","family":"Reed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-9605","authenticated-orcid":false,"given":"Hannah J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-1055","authenticated-orcid":false,"given":"Gibran","family":"Hemani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Zammit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-3684","authenticated-orcid":false,"given":"Oliver S. P.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"957-67","DOI":"10.1093\/oxfordjournals.schbul.a007145","article-title":"Sleep in untreated patients with schizophrenia: a meta-analysis.","volume":"30","author":"S Chouinard","year":"2004","journal-title":"Schizophr Bull."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"69-84","DOI":"10.1016\/j.smrv.2016.03.001","article-title":"Sleep in schizophrenia: A systematic review and meta-analysis of polysomnographic findings in case-control studies.","volume":"32","author":"M Chan","year":"2017","journal-title":"Sleep Med Rev."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"25-38","DOI":"10.1016\/j.smrv.2016.01.001","article-title":"A systematic review of the nature and correlates of sleep disturbance in early 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Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T17:45:11Z","timestamp":1583775911000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":26,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.15060.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.16848.r36265","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16848.r36264","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16848.r36264","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.16848.r36265","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.16848.r36265, Victoria Garfield, MRC Unit of Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, London, UK, 06 Sep 2019, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2#referee-response-36265","order":0,"name":"referee-response-36265","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.16848.r36264, Bryony Sheaves, Department of Psychiatry, University of Oxford, Oxford, UK, 18 Sep 2019, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-15\/v2#referee-response-36264","order":1,"name":"referee-response-36264","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported in part by the UK Medical Research Council Integrative Epidemiology Unit at the University of Bristol (Grant ref: MC_UU_12013\/1) and by MRC grant MR\/M006727\/1. The Wellcome Trust (Grant ref: 102215\/2\/13\/2) and the University of Bristol provide core support for ALSPAC. ZR was supported by a Wellcome Trust PhD studentship (Grant ref: 109104\/Z\/15\/Z). This study was also supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. GWAS data for children was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}