{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:27:57Z","timestamp":1767176877033,"version":"build-2238731810"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.15362.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000}}],"reference-count":47,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T00:00:00Z","timestamp":1572220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["PR-ST-0915-10015"],"award-info":[{"award-number":["PR-ST-0915-10015"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["087622"],"award-info":[{"award-number":["087622"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    Carriage of\n                    <ns4:italic>Neisseria meningitidis<\/ns4:italic>\n                    , the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999.\u00a0 The UKMenCar4 study was conducted in 2014\/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.15362.2","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T06:45:06Z","timestamp":1572245106000},"page":"118","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence"],"prefix":"10.12688","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-7772","authenticated-orcid":false,"given":"Holly B.","family":"Bratcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-3707","authenticated-orcid":false,"given":"Charlene M. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.16781.r36276, Derek J. Fairley, Belfast HSC Trust, Belfast, UK, 06 Sep 2019, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-118\/v1#referee-response-36276","order":0,"name":"referee-response-36276","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.16781.r36292, Annaliesa S. Anderson, Vaccine Research and Development, Pfizer, Pearl River, NY, USA, 17 Sep 2019, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/4-118\/v1#referee-response-36292","order":1,"name":"referee-response-36292","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was funded by the Wellcome Trust (087622), the UK Department of Health and the National Institute for Health Research (NIHR) Policy Research Programme (\u201cCharacterisation of meningococcal carriage isolates from UK MenCar4 study\", PR-ST-0915-10015). MDS and AJP are supported by the NIHR Oxford Biomedical Research Centre. AJP is an NIHR Senior Investigator. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}