{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:14:08Z","timestamp":1790964848241,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.15482.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["205954"],"award-info":[{"award-number":["205954"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that is difficult to diagnose and is part of the wider spectrum of urogenital disease caused by the waterborne parasite\u00a0\n                    <ns4:italic>Schistosoma haematobium<\/ns4:italic>\n                    .\u00a0Over\u00a090%\u00a0of\u00a0human\u00a0schistosomiasis cases are found in sub-Saharan Africa with 3.8 million people infected with schistosomes in Zambia. Reported FGS prevalence ranges from 33-75% of those with urinary schistosomiasis in endemic areas, suggesting a potentially high FGS burden in Zambia alone. The Bilharzia and HIV\n                  <\/ns4:p>\n                  <ns4:p>(BILHIV) study evaluated home self-sampling genital collection methods for the diagnosis of FGS.<\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : Eligible participants included non-pregnant, sexually active women aged 18-31 who were previously recruited for the HPTN 071\n                  <\/ns4:p>\n                  <ns4:p>(PopART) trial in Livingstone, Zambia. Household demographic and symptom questionnaires were administered by community workers. Participants were offered vaginal and cervical self-swabs and a urine cup. Cervicovaginal lavage (CVL) was performed in clinic by midwives. Information was collected from participants on the acceptability and feasibility of genital self-sampling.<\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : From January-August 2018, 603 women were enrolled, and 87.3% (527\/603) completed clinic follow up. A high proportion of participants indicated that self-collection of specimens was \u201ceasy\u201d or \u201cvery easy\u201d on a 5-point Likert scale. A high proportion of women would be willing to self-collect all three specimens again in future: vaginal swab 96.7%\n                  <\/ns4:p>\n                  <ns4:p>(583\/603), cervical swab 96.5% (582\/603), and urine 96.2% (580\/603). Overall, 90.0% (543\/603) preferred to self-collect samples at home, compared with sampling in the clinic Home-based self-sampling was preferred over provider-based sampling in the clinic due to greater privacy 65.0% (353\/543), convenience 51.4% (279\/543) and lack of needed transportation 17.7% (96\/543).<\/ns4:p>\n                  <ns4:p\/>\n                  <ns4:p>\n                    <ns4:bold>Conclusions<\/ns4:bold>\n                    : Home based genital self-sampling for FGS diagnosis is highly acceptable. This scalable method may inform future efforts for community-based diagnosis of FGS\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.15482.2","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T11:06:47Z","timestamp":1599044807000},"page":"61","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia"],"prefix":"10.12688","volume":"5","author":[{"given":"Comfort","family":"Rutty Phiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Sturt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-7456","authenticated-orcid":false,"given":"Emily 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[Data Collection].","author":"A Sturt","year":"2020"}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T07:20:20Z","timestamp":1602746420000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":32,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.15482.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.17751.r40248","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.17751.r40247","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.17751.r40248","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.17751.r40247","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.17751.r40248, Peter Leutscher, Center for Clinical Research, North Denmark Regional Hospital, Hj\u00f8rring, Denmark, 15 Oct 2020, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2#referee-response-40248","order":0,"name":"referee-response-40248","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.17751.r40247, Alexander Odaibo, Parasitology Research Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria, 09 Sep 2020, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/5-61\/v2#referee-response-40247","order":1,"name":"referee-response-40247","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [205954]. 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