{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:35Z","timestamp":1772169155224,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.16603.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000}}],"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT087997MA"],"award-info":[{"award-number":["WT087997MA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Council","award":["G9815508"],"award-info":[{"award-number":["G9815508"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["062199"],"award-info":[{"award-number":["062199"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>Background When the Avon Longitudinal Study of Parents and Children (ALSPAC) was planned, it was assumed that the clinical obstetric data would be easily accessible from the newly developed National Health Service computerised \u2018STORK\u2019 system. Pilot studies, however, showed that, although fairly accurate in regard to aspects of labour and delivery, it was, at the time (1990-2), inadequate for identifying the full antenatal and postnatal details of clinical complications and treatments of the women in the Study. Methods A scheme was therefore developed to train research staff to find and abstract relevant details from clinical records onto proformas designed for the purpose. Extracting such data proved very time consuming (up to six hours for complicated pregnancies) and consequently expensive. Funding for the enterprise was obtained piecemeal using specific focussed grants to extract data for subsamples of the Study, including a random sample to serve as controls. Results To date, detailed records have been completed for 8369 pregnancies, and a further 5336 (13,705 in total) have complete details on specific prenatal areas, including serial measures of maternal blood pressure, proteinuria and weight. In this Data Note we describe the information abstracted from the obstetric medical records concerning the mother during pregnancy, labour, delivery and the first two weeks of the puerperium. Information abstracted relating to the fetus (including fetal monitoring, presentation, method of delivery) and neonate (signs of asphyxia, resuscitation, treatment and well-being) have been described in a further Data Note. Conclusions These data add depth to ALSPAC concerning ways in which the signs and symptoms, procedures and treatments of the mother prenatally, intrapartum and postnatally, may impact on the long-term health and development of both mother and child. They augment the data collected from the mothers\u2019 questionnaires (described elsewhere) and the \u2018STORK\u2019 digital hospital data.<\/ns4:p>","DOI":"10.12688\/wellcomeopenres.16603.2","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T08:06:31Z","timestamp":1711440391000},"page":"41","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The mother during pregnancy and the puerperium: Detailed data abstracted from the clinical obstetric records of ALSPAC pregnancies"],"prefix":"10.12688","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-3307","authenticated-orcid":false,"given":"Karen","family":"Birmingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-9338","authenticated-orcid":false,"given":"Steven","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-9133","authenticated-orcid":false,"given":"Yasmin","family":"Iles-Caven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-9470","authenticated-orcid":false,"given":"Abigail","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-2262","authenticated-orcid":false,"given":"Deborah A.","family":"Lawlor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-3728","authenticated-orcid":false,"given":"Andrew","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-1983","authenticated-orcid":false,"given":"Kate","family":"Northstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-3307","authenticated-orcid":false,"given":"Jean","family":"Golding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","DOI":"10.1332\/9781447340423","article-title":"Pioneering Ethics in a Longitudinal Study: The Early Development of the ALSPAC Ethics and Law Committee.","author":"K Birmingham","year":"2018"},{"key":"ref-2","article-title":"ALSPAC Mother during pregnancy and the puerperium_data abstraction form.docx.","author":"K Birmingham","year":"2021a","journal-title":"figshare."},{"key":"ref-3","article-title":"ALSPAC Mother during pregnancy and the puerperium_data abstraction instructions.","author":"K Birmingham","year":"2021b","journal-title":"figshare."},{"key":"ref-4","article-title":"ALSPAC Mother during pregnancy and the puerperium_ abstraction checking instructions.","author":"K Birmingham","year":"2021c","journal-title":"figshare."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"298","DOI":"10.12688\/wellcomeopenres.17214.1","article-title":"The ALSPAC fetal and neonatal resource: detailed data abstracted from the clinical records of the new-born [version 1; 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It is true that obstetric practice may have changed over time but, we feel that&nbsp; in many respects the data are likely to provide useful information of relevance to the present day. Examples still of likely relevance include pre-eclampsia and placenta praevia. Of course there is the conundrum that if there are important long-term effects, they are unlikely to be evident for many years, by which time the particular exposure in question may not be in use. Nevertheless, it is important to document any long-term associations as they may be important to scientific understanding in the future.  The long-term outcomes in the mothers and children who have taken part in the ALSPAC study are continuously updated. Details can be retrieved from the ALSPAC website:&nbsp;Explore data and samples | Avon Longitudinal Study of Parents and Children | University of Bristol. Information available includes medical and psychological outcomes, genetic and epigenetic data as well as the results of various psychometric and anthropometric measurements. The developing database includes details of the offspring of the original study children, thus enabling research into transgenerational associations.","URL":"https:\/\/wellcomeopenresearch.org\/articles\/6-41\/v2#referee-comment-4998","order":1,"name":"referee-comment-4998","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Yasmin Iles-Caven<\/b>; \n<i>Posted: 16 Feb 2024<\/i>; Further to our previous comments, in regard to the points made concerning the fact that the data are out of date, we have updated the paper and added further explanation to the end of the Discussion concerning the probable relevance of the data to the analysis of factors contributing to the health of both the mothers and their offspring long-term.","URL":"https:\/\/wellcomeopenresearch.org\/articles\/6-41\/v2#referee-comment-5612","order":2,"name":"referee-comment-5612","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.18300.r67060, Wojciech Hanke, Nofer Institute of Occupational Medicine, \u0141\u00f3d\u017a, 25 Mar 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/wellcomeopenresearch.org\/articles\/6-41\/v1#referee-response-67060","order":3,"name":"referee-response-67060","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.23365.r81288, Jan van der Meulen, London School of Hygiene & Tropical Medicine, London, 26 Jun 2024, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/6-41\/v2#referee-response-81288","order":4,"name":"referee-response-81288","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The UK Medical Research Council and Wellcome Trust [217065] and the University of Bristol currently provide core support for ALSPAC. Data abstraction was funded by several grants including the Wellcome Trust [062199; 087997], the Medical Research Council [G9815508] and the US National Institutes of Health [R01 DK077659]; and others listed in 'The subsample strategy' subsection of this article.  \nThis publication is the work of the authors and they will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website (http:\/\/www.bristol.ac.uk\/alspac\/external\/documents\/grant-acknowledgements.pdf). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}