{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:12Z","timestamp":1772169132117,"version":"3.50.1"},"reference-count":124,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R015600\/1"],"award-info":[{"award-number":["MR\/R015600\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013589","name":"Research England","doi-asserted-by":"publisher","award":["BSA34"],"award-info":[{"award-number":["BSA34"]}],"id":[{"id":"10.13039\/501100013589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["208378"],"award-info":[{"award-number":["208378"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    The Infectious Diseases Data Observatory (IDDO,\n                    <ns4:underline>https:\/\/www.iddo.org<\/ns4:underline>\n                    ) has launched a clinical data platform for the collation, curation, standardisation and reuse of individual participant data (IPD) on treatments for two of the most globally important neglected tropical diseases (NTDs), schistosomiasis (SCH) and soil-transmitted helminthiases (STHs). This initiative aims to harness the power of data-sharing by facilitating collaborative joint analyses of pooled datasets to generate robust evidence on the efficacy and safety of anthelminthic treatment regimens. A crucial component of this endeavour has been the development of a Research Agenda to promote engagement with the SCH and STH research and disease control communities by highlighting key questions that could be tackled using data shared through the IDDO platform. Here, we give a contextual overview of the priority research themes articulated in the Research Agenda\u2014a \u2018living\u2019 document hosted on the IDDO website\u2014and describe the three-stage consultation process behind its development. We also discuss the sustainability and future directions of the platform, emphasising throughout the power and promise of ethical and equitable sharing and reuse of clinical data to support the elimination of NTDs.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.17468.1","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T10:25:06Z","timestamp":1641378306000},"page":"5","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-5365","authenticated-orcid":false,"given":"Martin","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzia T.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia B.","family":"Halder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-7371","authenticated-orcid":false,"given":"Matthew","family":"Brack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Levecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Ai-Lian Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otavio","family":"Pieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Sow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Russell","family":"Stothard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne P.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3849-7705","authenticated-orcid":false,"given":"Robert F.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-2963","authenticated-orcid":false,"given":"Philippe J.","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"e0005424","DOI":"10.1371\/journal.pntd.0005424","article-title":"The global burden of disease study 2013: What does it mean for the NTDs?","volume":"11","author":"J Herricks","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1018-27","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases.","volume":"357","author":"P Hotez","year":"2007","journal-title":"N Engl J Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1570-5","DOI":"10.1016\/S0140-6736(09)60233-6","article-title":"Rescuing the bottom billion through control of neglected tropical diseases.","volume":"373","author":"P Hotez","year":"2009","journal-title":"Lancet."},{"key":"ref-4","article-title":"Ending the neglect to attain the Sustainable Development Goals - A road map for neglected tropical diseases 2021-2030.","year":"2021"},{"key":"ref-5","article-title":"Neglected tropical diseases: treating more than one billion people for the fifth consecutive year.","year":"2020"},{"key":"ref-6","article-title":"Crossing the Billion. Preventive chemotherapy for neglected tropical diseases. Lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiases and trachoma.","year":"2017"},{"key":"ref-7","first-page":"629-40","article-title":"Schistosomiasis and soil-transmitted helminthiases: numbers of people treated in 2019.","volume":"95","year":"2020","journal-title":"Wkly Epidemiol Rec."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"75-80","DOI":"10.1016\/j.smallrumres.2015.12.014","article-title":"Anthelmintic resistance in sheep gastro-intestinal strongyles in Europe.","volume":"135","author":"D Traversa","year":"2016","journal-title":"Small Rumin Res."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"310-5","DOI":"10.1016\/j.ijpddr.2014.10.003","article-title":"Anthelmintic resistance in equine nematodes.","volume":"4","author":"J Matthews","year":"2014","journal-title":"Int J Parsitol Drugs Drug Resist."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"477-81","DOI":"10.1016\/j.pt.2004.08.001","article-title":"Drug resistance in nematodes of veterinary importance: a status report.","volume":"20","author":"R Kaplan","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"469-76","DOI":"10.1016\/j.pt.2004.07.010","article-title":"Drug resistance in veterinary helminths.","volume":"20","author":"A Wolstenholme","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"i5295","DOI":"10.1136\/bmj.i5295","article-title":"Beyond open data: realising the health benefits of sharing data.","volume":"355","author":"E Pisani","year":"2016","journal-title":"BMJ."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"2414-5","DOI":"10.1056\/NEJMp1605148","article-title":"Avoiding data dumpsters\u2014toward equitable and useful data sharing.","volume":"374","author":"L Merson","year":"2016","journal-title":"N Engl J Med."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"13-5","DOI":"10.4269\/ajtmh.18-0649","article-title":"Strength in Numbers: The WWARN case study of purpose-driven data sharing.","volume":"100","author":"G Humphreys","year":"2019","journal-title":"Am J Trop Med Hyg."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"e965","DOI":"10.1016\/S2214-109X(18)30341-3","article-title":"Secondary analysis and participation of those at the data source.","volume":"6","author":"L Merson","year":"2018","journal-title":"Lancet Glob Health."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"302-13","DOI":"10.1177\/1556264615594606","article-title":"Best Practices for Ethical Sharing of Individual-Level Health Research data from low- and middle-income settings.","volume":"10","author":"S Bull","year":"2015","journal-title":"J Empir Res Hum Res Ethics."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"e0006053","DOI":"10.1371\/journal.pntd.0006053","article-title":"Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing.","volume":"11","author":"J Halder","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"e0004784","DOI":"10.1371\/journal.pntd.0004784","article-title":"The schistosomiasis clinical trials landscape: a systematic review of antischistosomal treatment efficacy studies and a case for sharing individual participant-level data (IPD).","volume":"10","author":"A Jul\u00e9","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13071-016-1312-0","article-title":"New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel.","volume":"9","author":"M Walker","year":"2016","journal-title":"Parasit Vectors."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"528-37","DOI":"10.1016\/j.pt.2014.08.004","article-title":"Models for measuring anthelmintic drug efficacy for parasitologists.","volume":"30","author":"M Walker","year":"2014","journal-title":"Trends Parasitol."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"e0003821","DOI":"10.1371\/journal.pntd.0003821","article-title":"Toward measuring Schistosoma response to praziquantel treatment with appropriate descriptors of egg excretion.","volume":"9","author":"P Olliaro","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"e0009888","DOI":"10.1371\/journal.pntd.0009888","article-title":"Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure.","volume":"15","author":"M Walker","year":"2021","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"e0007471","DOI":"10.1371\/journal.pntd.0007471","article-title":"Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods.","volume":"13","author":"J Vlaminck","year":"2019","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"e948","DOI":"10.1371\/journal.pntd.0000948","article-title":"Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic.","volume":"5","author":"J Vercruysse","year":"2011","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"183-7","DOI":"10.1016\/j.ijpddr.2020.10.003","article-title":"Evaluation of the therapeutic efficacy of praziquantel against schistosomes in seven countries with ongoing large-scale deworming programs.","volume":"14","author":"B Levecke","year":"2020","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"j4307","DOI":"10.1136\/bmj.j4307","article-title":"Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis.","volume":"358","author":"W Moser","year":"2017","journal-title":"BMJ."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"e0004057","DOI":"10.1371\/journal.pntd.0004057","article-title":"Assessment of efficacy and quality of two albendazole brands commonly used against soil-transmitted helminth infections in school children in Jimma Town, Ethiopia.","volume":"9","author":"S Belew","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"e3345","DOI":"10.1371\/journal.pntd.0003345","article-title":"Quality of medicines commonly used in the treatment of soil-transmitted helminths and Giardia in Ethiopia: a nationwide survey.","volume":"8","author":"S Suleman","year":"2014","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"1151-9","DOI":"10.1093\/cid\/ciw506","article-title":"Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple rounds of mass drug administration.","volume":"63","author":"T Crellen","year":"2016","journal-title":"Clin Infect Dis."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"932-5","DOI":"10.4269\/ajtmh.1999.60.932","article-title":"Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.","volume":"60","author":"M Ismail","year":"1999","journal-title":"Am J Trop Med Hyg."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"e504","DOI":"10.1371\/journal.pntd.0000504","article-title":"Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni.","volume":"3","author":"S Melman","year":"2009","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"167-70","DOI":"10.4269\/ajtmh.1995.53.167","article-title":"Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni.","volume":"53","author":"F Stelma","year":"1995","journal-title":"Am J Trop Med Hyg."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"e02582-16","DOI":"10.1128\/AAC.02582-16","article-title":"Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance.","volume":"61","author":"N Vale","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"585-94","DOI":"10.3201\/eid0606.000606","article-title":"Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium,. Kenya.","volume":"6","author":"C King","year":"2000","journal-title":"Emerg Infect Dis."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"e0009189","DOI":"10.1371\/journal.pntd.0009189","article-title":"Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy.","volume":"15","author":"M Fukushige","year":"2021","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"493-501","DOI":"10.1093\/trstmh\/trt051","article-title":"Comparison of three copromicroscopic methods to assess albendazole efficacy against soil-transmitted helminth infections in school-aged children on Pemba Island.","volume":"107","author":"M Albonico","year":"2013","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"351-6","DOI":"10.4269\/ajtmh.18-0727","article-title":"Genetic markers of benzimidazole resistance among human hookworms ( Necator americanus) in Kintampo North municipality, Ghana.","volume":"100","author":"A Orr","year":"2019","journal-title":"Am J Trop Med Hyg."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"e2247","DOI":"10.1371\/journal.pntd.0002247","article-title":"Association between response to albendazole treatment and \u03b2-tubulin genotype frequencies in soil-transmitted helminths.","volume":"7","author":"A Diawara","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"e0003494","DOI":"10.1371\/journal.pntd.0003494","article-title":"The emergence of resistance to the benzimidazole anthlemintics in parasitic nematodes of livestock is characterised by multiple independent hard and soft selective sweeps.","volume":"9","author":"E Redman","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"666-7","DOI":"10.1016\/S0140-6736(01)05796-8","article-title":"Counterfeit praziquantel.","volume":"358","author":"S Sulaiman","year":"2001","journal-title":"Lancet."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"iii36-iii47","DOI":"10.1093\/heapol\/czz012","article-title":"Poor-quality antimalarials further health inequities in Uganda.","volume":"34","author":"D Evans","year":"2019","journal-title":"Health Policy Plan."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"531-3","DOI":"10.1080\/14787210.2016.1187560","article-title":"A link between poor quality antimalarials and malaria drug resistance?","volume":"14","author":"P Newton","year":"2016","journal-title":"Expert Rev Anti Infect Ther."},{"key":"ref-43","article-title":"Guidlines for the treatment of malaria","year":"2015"},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"67-74","DOI":"10.1016\/j.ebiom.2017.02.017","article-title":"African Genetic Diversity: Implications for cytochrome P450-mediated drug metabolism and drug development.","volume":"17","author":"I Rajman","year":"2017","journal-title":"EBioMedicine."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"e0006144","DOI":"10.1371\/journal.pntd.0006144","article-title":"Paediatric schistosomiasis: What we know and what we need to know.","volume":"12","author":"D Osakunor","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"411-423","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum. malaria.","volume":"371","author":"E Ashley","year":"2014","journal-title":"N Eng J Med."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"e688-e98","DOI":"10.1016\/S2214-109X(17)30187-0","article-title":"Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial.","volume":"5","author":"J Coulibaly","year":"2017","journal-title":"Lancet Glob Health."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"e00227-16","DOI":"10.1128\/mBio.00227-16","article-title":"Population pharmacokinetics and pharmacodynamics of praziquantel in Ugandan children with intestinal schistosomiasis: higher dosages are required for maximal efficacy.","volume":"7","author":"A Bustinduy","year":"2016","journal-title":"mBio."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s40249-018-0448-x","article-title":"Efficacy of praziquantel treatment regimens in pre-school and school aged children infected with schistosomiasis in sub-Saharan Africa: a systematic review.","volume":"7","author":"M Kabuyaya","year":"2018","journal-title":"Infect Dis Poverty."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"e1321","DOI":"10.1371\/journal.pntd.0001321","article-title":"Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review.","volume":"5","author":"C King","year":"2011","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"2903-4","DOI":"10.1128\/AAC.44.10.2903-2904.2000","article-title":"Bioavailability of praziquantel increases with concomitant administration of food.","volume":"44","author":"N Castro","year":"2000","journal-title":"Antimicrob Agents Chemother."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"389-93","DOI":"10.1016\/0035-9203(90)90333-a","article-title":"Pharmacokinetics of praziquantel in healthy volunteers and patients with schistosomiasis.","volume":"84","author":"M Mandour","year":"1990","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"e3286","DOI":"10.1371\/journal.pntd.0003286","article-title":"Clinical efficacy and tolerability of praziquantel for intestinal and urinary schistosomiasis-a meta-analysis of comparative and non-comparative clinical trials.","volume":"8","author":"J Zwang","year":"2014","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.3390\/microorganisms9081776","article-title":"Hybridized zoonotic Schistosoma. infections result in hybridized morbidity profiles: a clinical morbidity study amongst co-infected human populations of Senegal.","volume":"9","author":"C Fall","year":"2021","journal-title":"Microorganisms."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"65-80","DOI":"10.1017\/S0031182016001190","article-title":"Hybridizations within the Genus Schistosoma: implications for evolution, epidemiology and control.","volume":"144","author":"E Leger","year":"2017","journal-title":"Parasitology."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"244-7","DOI":"10.1093\/trstmh\/trx047","article-title":"Should we be treating animal schistosomiasis in Africa? The need for a One Health economic evaluation of schistosomiasis control in people and their livestock.","volume":"111","author":"C Gower","year":"2017","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"586-90","DOI":"10.1016\/j.trstmh.2011.07.009","article-title":"Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura. in school-age children in Uganda.","volume":"105","author":"H Namwanje","year":"2011","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"443-6","DOI":"10.1016\/j.trstmh.2008.12.010","article-title":"Albendazole and mebendazole have low efficacy against Trichuristrichiura in school-age children in Kabale District, Uganda.","volume":"103","author":"A Olsen","year":"2009","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"207-9","DOI":"10.1179\/2047773213Y.0000000092","article-title":"Efficacy of different albendazole and mebendazole regimens against heavy-intensity Trichuris trichiura. infections in school children, Jimma Town, Ethiopia.","volume":"107","author":"Z Mekonnen","year":"2013","journal-title":"Pathog Glob Health."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"128-30","DOI":"10.1016\/j.trstmh.2011.09.007","article-title":"The impact of baseline faecal egg counts on the efficacy of single-dose albendazole against Trichuris trichiura.","volume":"106","author":"B Levecke","year":"2012","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"7-13","DOI":"10.1016\/j.eclinm.2018.06.004","article-title":"Efficacy and safety of a single dose versus a multiple dose regimen of mebendazole against hookworm infections in children: a randomised, double-blind trial.","volume":"1","author":"M Palmeirim","year":"2018","journal-title":"EClinicalMedicine."},{"key":"ref-62","doi-asserted-by":"crossref","first-page":"732-6","DOI":"10.4269\/ajtmh.2007.76.732","article-title":"Low efficacy of mebendazole against hookworm in Vietnam: two randomized controlled trials.","volume":"76","author":"C Flohr","year":"2007","journal-title":"Am J Trop Med Hyg."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"277-84","DOI":"10.1016\/S1473-3099(14)71050-3","article-title":"Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.","volume":"15","author":"B Speich","year":"2015","journal-title":"Lancet Infect Dis."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"1420-8","DOI":"10.1086\/657310","article-title":"Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial.","volume":"51","author":"S Knopp","year":"2010","journal-title":"Clin Infect Dis."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"747-58","DOI":"10.1016\/j.trstmh.2007.03.006","article-title":"Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis.","volume":"101","author":"A Olsen","year":"2007","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-66","first-page":"35-42","article-title":"A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp.","volume":"81","author":"V Belizario","year":"2003","journal-title":"Bull World Health Organ."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"1162-71","DOI":"10.1016\/S1473-3099(17)30487-5","article-title":"Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Cote d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.","volume":"17","author":"W Moser","year":"2017","journal-title":"Lancet Infect Dis."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"610-20","DOI":"10.1056\/NEJMoa1301956","article-title":"Oxantel pamoate-albendazole for Trichuris trichiura infection.","volume":"370","author":"B Speich","year":"2014","journal-title":"N Engl J Med."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"1193-201","DOI":"10.1093\/cid\/ciz326","article-title":"Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial.","volume":"70","author":"L Keller","year":"2020","journal-title":"Clin Infect Dis."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"125-9","DOI":"10.1016\/s1471-4922(01)02209-7","article-title":"Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal.","volume":"18","author":"A Danso-Appiah","year":"2002","journal-title":"Trends Parasitol."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"864-73","DOI":"10.1046\/j.1365-3156.2001.00811.x","article-title":"Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence.","volume":"6","author":"B Gryseels","year":"2001","journal-title":"Trop Med Int Health."},{"key":"ref-72","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1756-3305-5-135","article-title":"Intestinal parasitic infections in schoolchildren in different settings of Cote d'Ivoire: effect of diagnostic approach and implications for control.","volume":"5","author":"J Coulibaly","year":"2012","journal-title":"Parasit Vectors."},{"key":"ref-73","first-page":"343-52","article-title":"Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar.","volume":"81","author":"M Albonico","year":"2003","journal-title":"Bull World Health Organ."},{"key":"ref-74","article-title":"Ninth meeting of Working Group on Monitoring of Neglected Tropical Diseases Drug Efficacy","year":"2020"},{"key":"ref-75","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13071-017-2580-z","article-title":"Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda.","volume":"11","author":"J Prada","year":"2018","journal-title":"Parasit Vectors."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"e0003752","DOI":"10.1371\/journal.pntd.0003752","article-title":"Sensitivity and specificity of a urine circulating anodic antigen test for the diagnosis of Schistosoma haematobium in low endemic settings.","volume":"9","author":"S Knopp","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-77","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s13071-018-2838-0","article-title":"Use of quantitative PCR to assess the efficacy of albendazole against Necator americanusand Ascarisspp. in Manufahi District, Timor-Leste.","volume":"11","author":"S Vaz Nery","year":"2018","journal-title":"Parasit Vectors."},{"key":"ref-78","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13071-016-1314-y","article-title":"Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming.","volume":"9","author":"A Easton","year":"2016","journal-title":"Parasit Vectors."},{"key":"ref-79","doi-asserted-by":"publisher","first-page":"e0006054","DOI":"10.1371\/journal.pntd.0006054","article-title":"Rapid clearance of Schistosoma mansonicirculating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community - Relevance for monitoring treatment efficacy and re-infection.","volume":"11","author":"A Kildemoes","year":"2017","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-80","doi-asserted-by":"publisher","first-page":"311-2","DOI":"10.1016\/0035-9203(93)90142-d","article-title":"Circulating cathodic antigen levels in serum and urine of schistosomiasis patients before and after chemotherapy with praziquantel.","volume":"87","author":"L van Lieshout","year":"1993","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-81","doi-asserted-by":"publisher","first-page":"323-8","DOI":"10.4269\/ajtmh.1991.44.323","article-title":"Assessment of cure in schistosomiasis patients after chemotherapy with praziquantel by quantitation of circulating anodic antigen (CAA) in urine.","volume":"44","author":"L van Lieshout","year":"1991","journal-title":"Am J Trop Med Hyg."},{"key":"ref-82","doi-asserted-by":"publisher","first-page":"e0008189","DOI":"10.1371\/journal.pntd.0008189","article-title":"Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Cote d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).","volume":"14","author":"P Hoekstra","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-83","doi-asserted-by":"publisher","first-page":"45-51","DOI":"10.1016\/j.trstmh.2008.08.018","article-title":"Use of circulating cathodic antigen strips for the diagnosis of urinary schistosomiasis.","volume":"103","author":"N Midzi","year":"2009","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-84","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.3389\/fimmu.2018.02635","article-title":"Refining Diagnosis of Schistosoma haematobium Infections: Antigen and Antibody Detection in Urine.","volume":"9","author":"C de Dood","year":"2018","journal-title":"Front Immunol."},{"key":"ref-85","doi-asserted-by":"publisher","first-page":"e0006130","DOI":"10.1371\/journal.pntd.0006130","article-title":"A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen.","volume":"12","author":"M Papaiakovou","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-86","doi-asserted-by":"publisher","first-page":"e0008231","DOI":"10.1371\/journal.pntd.0008231","article-title":"First international external quality assessment scheme of nucleic acid amplification tests for the detection of Schistosoma and soil-transmitted helminths, including Strongyloides: a pilot study.","volume":"14","author":"P Cools","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-87","doi-asserted-by":"publisher","first-page":"e0009134","DOI":"10.1371\/journal.pntd.0009134","article-title":"Quantitative PCR in soil-transmitted helminth epidemiology and control programs: Toward a universal standard.","volume":"15","author":"P Cools","year":"2021","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-88","doi-asserted-by":"publisher","first-page":"698-708","DOI":"10.1016\/j.pt.2021.04.005","article-title":"How qPCR complements the WHO roadmap (2021-2030) for soil-transmitted helminths.","volume":"37","author":"M Papaiakovou","year":"2021","journal-title":"Trends Parasitol."},{"key":"ref-89","doi-asserted-by":"publisher","first-page":"105863","DOI":"10.1016\/j.actatropica.2021.105863","article-title":"Low specificity of point-of-care circulating cathodic antigen (POCCCA) diagnostic test in a non-endemic area for schistosomiasis mansoni in Brazil.","volume":"217","author":"C Graeff-Teixeira","year":"2021","journal-title":"Acta Trop."},{"key":"ref-90","article-title":"Assessing the efficacy of anthelmintic drugs against schistosomiasis and soil-transmitted helminthiases","year":"2013"},{"key":"ref-91","doi-asserted-by":"publisher","first-page":"67-9","DOI":"10.1016\/j.ijpddr.2017.12.004","article-title":"The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans.","volume":"8","author":"B Levecke","year":"2018","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"ref-92","doi-asserted-by":"publisher","first-page":"226-31","DOI":"10.1016\/j.actatropica.2008.11.015","article-title":"Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration.","volume":"109","author":"A Scherrer","year":"2009","journal-title":"Acta Trop."},{"key":"ref-93","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/1756-3305-5-298","article-title":"Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children.","volume":"5","author":"K Stete","year":"2012","journal-title":"Parasit Vectors."},{"key":"ref-94","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40249-016-0150-9","article-title":"Assessing stool quantities generated by three specific Kato-Katz thick smear templates employed in different settings.","volume":"5","author":"A Leuenberger","year":"2016","journal-title":"Infect Dis Poverty."},{"key":"ref-95","doi-asserted-by":"publisher","first-page":"836-841","DOI":"10.4269\/ajtmh.20-1219","article-title":"A systematic literature review of microscopy methods reported in malaria clinical trials.","volume":"104","author":"D Das","year":"2020","journal-title":"Am J Trop Med Hyg."},{"key":"ref-96","doi-asserted-by":"publisher","first-page":"S195-S202","DOI":"10.1093\/cid\/ciab196","article-title":"Survey design to monitor drug efficacy for the control of soil-transmitted helminthiasis and schistosomiasis.","volume":"72","author":"L Coffeng","year":"2021","journal-title":"Clin Infect Dis."},{"key":"ref-97","first-page":"499-501","article-title":"Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya.","volume":"73","author":"W Jaoko","year":"1996","journal-title":"East Afr Med J."},{"key":"ref-98","doi-asserted-by":"publisher","first-page":"53-63","DOI":"10.1016\/s0001-706x(98)00084-9","article-title":"Praziquantel side effects and efficacy related to Schistosoma mansoni egg loads and morbidity in primary school children in north-east Ethiopia.","volume":"72","author":"N Berhe","year":"1999","journal-title":"Acta Trop."},{"key":"ref-99","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1186\/s12879-015-1158-7","article-title":"Reduced uptake of mass treatment for schistosomiasis control in absence of food: beyond a randomized trial.","volume":"15","author":"S Muhumuza","year":"2015","journal-title":"BMC Infect Dis."},{"key":"ref-100","doi-asserted-by":"publisher","first-page":"e0006578","DOI":"10.1371\/journal.pntd.0006578","article-title":"Risk of adverse swallowing events and choking during deworming for preschool-aged children.","volume":"12","author":"J Kernell","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-101","doi-asserted-by":"publisher","first-page":"223-32","DOI":"10.1016\/s0001-706x(03)00042-1","article-title":"Use of benzimidazoles in children younger than 24 months for the treatment of soil-transmitted helminthiasis.","volume":"86","author":"A Montresor","year":"2003","journal-title":"Acta Trop."},{"key":"ref-102","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1371\/journal.pntd.0000126","article-title":"Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy.","volume":"2","author":"M Albonico","year":"2008","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-103","doi-asserted-by":"publisher","first-page":"e0006458","DOI":"10.1371\/journal.pntd.0006458","article-title":"Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: a systematic review, meta-analysis and individual patient data analysis.","volume":"12","author":"M Palmeirim","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-104","doi-asserted-by":"publisher","first-page":"e0009144","DOI":"10.1371\/journal.pntd.0009144","article-title":"A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to reconsider the current contraindication?","volume":"15","author":"P Jittamala","year":"2021","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-105","doi-asserted-by":"publisher","first-page":"i15-8","DOI":"10.1093\/inthealth\/ihw002","article-title":"Leaving no one behind: a neglected tropical disease indicator and tracers for the Sustainable Development Goals.","volume":"8 Suppl 1","author":"C Fitzpatrick","year":"2016","journal-title":"Int Health."},{"key":"ref-106","doi-asserted-by":"publisher","first-page":"540-3","DOI":"10.1016\/j.trstmh.2004.01.001","article-title":"Is praziquantel therapy safe during pregnancy?","volume":"98","author":"I Adam","year":"2004","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-107","doi-asserted-by":"publisher","first-page":"199-208","DOI":"10.1016\/S1473-3099(15)00345-X","article-title":"Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial.","volume":"16","author":"R Olveda","year":"2016","journal-title":"Lancet Infect Dis."},{"key":"ref-108","doi-asserted-by":"publisher","first-page":"525-6","DOI":"10.1016\/S1473-3099(16)30009-3","article-title":"Praziquantel for schistosomiasis in pregnancy.","volume":"16","author":"C Qian","year":"2016","journal-title":"Lancet Infect Dis."},{"key":"ref-109","doi-asserted-by":"publisher","first-page":"59-65","DOI":"10.2471\/BLT.17.198879","article-title":"Praziquantel for the treatment of schistosomiasis during human pregnancy.","volume":"96","author":"J Friedman","year":"2018","journal-title":"Bull World Health Organ."},{"key":"ref-110","doi-asserted-by":"publisher","first-page":"CD005547","DOI":"10.1002\/14651858.CD005547.pub2","article-title":"Effect of administration of antihelminthics for soil transmitted helminths during pregnancy.","author":"B Haider","year":"2009","journal-title":"Cochrane Database Syst Rev."},{"key":"ref-111","doi-asserted-by":"publisher","first-page":"531-40","DOI":"10.1086\/649924","article-title":"Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial.","volume":"50","author":"J Ndibazza","year":"2010","journal-title":"Clin Infect Dis."},{"key":"ref-112","doi-asserted-by":"publisher","first-page":"e0007901","DOI":"10.1371\/journal.pntd.0007901","article-title":"Ruling out early trimester pregnancy when implementing community-based deworming programs.","volume":"14","author":"K St-Denis","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-113","doi-asserted-by":"publisher","first-page":"e0007406","DOI":"10.1371\/journal.pntd.0007406","article-title":"Provision of deworming intervention to pregnant women by antenatal services in countries endemic for soil-transmitted helminthiasis.","volume":"13","author":"M Bangert","year":"2019","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-114","doi-asserted-by":"publisher","first-page":"582-91","DOI":"10.1016\/j.pt.2020.04.012","article-title":"Schistosomiasis control: leave no age group behind.","volume":"36","author":"C Faust","year":"2020","journal-title":"Trends Parasitol."},{"key":"ref-115","doi-asserted-by":"publisher","first-page":"e640-e1","DOI":"10.1016\/S2214-109X(17)30202-4","article-title":"Treatment of preschool children for schistosomiasis.","volume":"5","author":"A Montresor","year":"2017","journal-title":"Lancet Glob Health."},{"key":"ref-116","doi-asserted-by":"publisher","first-page":"103-13","DOI":"10.1016\/j.inhe.2010.02.003","article-title":"Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing pole.","volume":"2","author":"J Sousa-Figueiredo","year":"2010","journal-title":"Int Health."},{"key":"ref-117","first-page":"440-445","article-title":"Pharmacopoeial standards: ensuring the efficacy of a deworming medicine: albendazole chewable tablets.","volume":"29","year":"2015","journal-title":"WHO Drug Information."},{"key":"ref-118","doi-asserted-by":"publisher","first-page":"100556","DOI":"10.1016\/j.eclinm.2020.100556","article-title":"Efficacy, safety and acceptability of a new chewable formulation versus the solid tablet of mebendazole against hookworm infections in children: an open-label, randomized controlled trial.","volume":"27","author":"M Palmeirim","year":"2020","journal-title":"EClinicalMedicine."},{"key":"ref-119","doi-asserted-by":"publisher","first-page":"1851-1856","DOI":"10.4269\/ajtmh.17-0108","article-title":"Efficacy and safety of a single-dose mebendazole 500 mg chewable, rapidly-disintegrating tablet for Ascaris lumbricoides and Trichuris trichiura infection treatment in pediatric patients: a double-blind, randomized, placebo-controlled, phase 3 study.","volume":"97","author":"S Silber","year":"2017","journal-title":"Am J Trop Med Hyg."},{"key":"ref-120","article-title":"Promoting safety of medicines for children.","year":"2007"},{"key":"ref-121","article-title":"A hypothesis testing framework for the ratio of means of two negative binomial distributions: classifying the efficacy of anthelmintic treatment against intestinal parasites","author":"M Denwood","year":"2019"},{"key":"ref-122","doi-asserted-by":"publisher","first-page":"316-23","DOI":"10.1016\/j.prevetmed.2009.11.009","article-title":"Comparison of three alternative methods for analysis of equine Faecal Egg Count Reduction Test data.","volume":"93","author":"M Denwood","year":"2010","journal-title":"Prev Vet Med."},{"key":"ref-123","doi-asserted-by":"publisher","first-page":"299-303","DOI":"10.1016\/j.ijpara.2014.01.005","article-title":"Evaluating faecal egg count reduction using a specifically designed package \"eggCounts\" in R and a user friendly web interface.","volume":"44","author":"P Torgerson","year":"2014","journal-title":"Int J Parasitol."},{"key":"ref-124","doi-asserted-by":"publisher","first-page":"1151-60","DOI":"10.1016\/S1473-3099(20)30691-5","article-title":"Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial.","volume":"21","author":"D Hofmann","year":"2021","journal-title":"Lancet Infect Dis."}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T05:25:20Z","timestamp":1650345920000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":124,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.17468.1","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.19316.r49330","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.19316.r47843","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.19316.r49330","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.19316.r47843","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.19316.r47843, John Gilleard, Dept of Comparative Biology and Experimental Medicine, Host-Parasite Interactions Program, University of Calgary, Calgary, AB, Canada, 27 Jan 2022, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1#referee-response-47843","order":0,"name":"referee-response-47843","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.19316.r49330, Nana-Kwadwo Biritwum, National Neglected Tropical Disease Control Programme, Ghana Health Services (GHS), Accra, Ghana, 19 Apr 2022, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-5\/v1#referee-response-49330","order":1,"name":"referee-response-49330","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"MW acknowledges funding from Research England\u2019s Connecting Capabilities Fund (Bloomsbury SET [https:\/\/bloomsburyset.org.uk\/]; BSA34). This work was supported by Wellcome (208378, <a href=https:\/\/doi.org\/10.35802\/208378>https:\/\/doi.org\/10.35802\/208378<\/a>; a Wellcome Biomedical Resources grant to MW, LTF, JBH, MB and PJG for the Infectious Diseases Data Observatory [https:\/\/www.iddo.org\/]). MGB acknowledges funding from the Medical Research Council (MRC) Centre for Global Infectious Disease Analysis (MR\/R015600\/1), jointly funded by the UK MRC and the UK Foreign, Commonwealth & Development Office (FCDO), under the MRC\/FCDO Concordat agreement and is also part of the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme supported by the European Union. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}