{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:42Z","timestamp":1772169162530,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.17522.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000}}],"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["110110\/Z\/15\/Z"],"award-info":[{"award-number":["110110\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns3:p>Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used for routine surveillance (alanine transferase [ALT] and HBV viral load). Methods We used anonymized electronic health record data from the National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) pipeline representing five UK National Health Service (NHS) Trusts. Results We report significant reductions in surveillance of both biomarkers during the pandemic compared to pre-COVID-19 years, both in terms of the proportion of patients who had \u22651 measurement annually, and the mean number of measurements per patient. Conclusions These results demonstrate the real-time utility of HIC data in monitoring health-care provision, and support interventions to provide catch-up services to minimise the impact of the pandemic. Further investigation is required to determine whether these disruptions will be associated with increased rates of adverse chronic HBV outcomes.<\/ns3:p>","DOI":"10.12688\/wellcomeopenres.17522.2","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T09:40:08Z","timestamp":1700041208000},"page":"51","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5890-7105","authenticated-orcid":false,"given":"Cori","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-9494","authenticated-orcid":false,"given":"Tingyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-7137","authenticated-orcid":false,"given":"David A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-9497","authenticated-orcid":false,"given":"Kinga A","family":"V\u00e1rnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-325X","authenticated-orcid":false,"given":"Steve","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-7799","authenticated-orcid":false,"given":"Hizni","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-0181","authenticated-orcid":false,"given":"Gail","family":"Roadknight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Glampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9076-5717","authenticated-orcid":false,"given":"Luca","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri","family":"Papadimitriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vince","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afzal","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina","family":"Borca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-8542","authenticated-orcid":false,"given":"Josune","family":"Olza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frazer","family":"Warricker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-5289","authenticated-orcid":false,"given":"Luis","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ramlakhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"English","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-1074","authenticated-orcid":false,"given":"Monique I.","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Nastouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim I.","family":"Khakoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Gelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-5056","authenticated-orcid":false,"given":"Graham S.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerrie","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-0831","authenticated-orcid":false,"given":"Eleanor","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa C.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"ref-1","article-title":"Global Health Sector Strategy on viral hepatitis 2016\u2013 2021.","year":"2016"},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1-98","DOI":"10.1007\/s12072-015-9675-4","article-title":"Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.","volume":"10","author":"S Sarin","year":"2016","journal-title":"Hepatol Int."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1560-99","DOI":"10.1002\/hep.29800","article-title":"Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.","volume":"67","author":"N Terrault","year":"2018","journal-title":"Hepatology."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"370-98","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.","volume":"67","year":"2017","journal-title":"J Hepatol."},{"key":"ref-5","first-page":"370-98","article-title":"The summarized of EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection.","volume":"67","year":"2017","journal-title":"J Hepatol."},{"key":"ref-6","first-page":"1-36","article-title":"Hepatitis B (chronic): diagnosis and management","volume":"2016","year":"2017"},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"e004275","DOI":"10.1136\/bmjgh-2020-004275","article-title":"The global impact of the COVID-19 pandemic on the prevention, diagnosis and treatment of hepatitis B virus (HBV) infection.","volume":"6","author":"C Pley","year":"2021","journal-title":"BMJ Glob Health."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"792-4","DOI":"10.1016\/S2468-1253(20)30238-7","article-title":"The impact of COVID-19 on hepatitis elimination.","volume":"5","author":"C Wingrove","year":"2020","journal-title":"Lancet Gastroenterol Hepatol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e100145","DOI":"10.1136\/bmjhci-2020-100145","article-title":"National Institute for Health Research Health Informatics Collaborative: Development of a pipeline to collate electronic clinical data for viral hepatitis research.","volume":"27","author":"D Smith","year":"2020","journal-title":"BMJ Health Care Inform."},{"key":"ref-10","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.21.21265205","article-title":"Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset.","author":"T Wang","year":"2021","journal-title":"medRxiv."},{"key":"ref-11","article-title":"WHO Coronavirus (COVID-19) Dashboard."},{"key":"ref-12","article-title":"Coronavirus (COVID-19) in the UK.","year":"2021"},{"key":"ref-13","article-title":"Clinical guide for the management of remote consultations and remote working in secondary care during the coronavirus pandemic.","year":"2020"},{"key":"ref-14","article-title":"The impact of Covid-19 on the use of digital technology in the NHS.","author":"R Hutchings","year":"2020"},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"585-8","DOI":"10.1089\/AID.2020.0301","article-title":"Impact of Coronavirus Disease 2019 Pandemic on Viral Hepatitis Elimination: What Is the Price?","volume":"37","author":"L Sowah","year":"2021","journal-title":"AIDS Res Hum Retroviruses."}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T10:30:16Z","timestamp":1714041016000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":15,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.17522.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.21838.r75872","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.21838.r75872","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.11.10.21265651","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.19374.r54846, Dorcas Obiri-Yeboah, Clinical Microbiology\/Public Health Unit, Cape Coast Teaching Hospital, Cape Coast, 28 Feb 2023, version 1, 1 approved","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v1#referee-response-54846","order":0,"name":"referee-response-54846","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.21838.r75872, James Van Yperen, University of Sussex, Brighton, England, 25 Apr 2024, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-51\/v2#referee-response-75872","order":1,"name":"referee-response-75872","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome (110110\/Z\/15\/Z, to Philippa C. Matthews). This work has been conducted using National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) data resources and funded by the NIHR HIC, and has been supported by NIHR Biomedical Research Centres at Cambridge, Imperial, Oxford, Southampton, and University College London Hospitals. GSC is an NIHR research professor, EB is an NIHR senior investigator. PCM holds an NIHR Senior Fellowship award. CC is a doctoral student who receives partial doctoral funding from GlaxoSmithKline (GSK). FW is an NIHR-funded ACF. The views expressed in this letter are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}