{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:57Z","timestamp":1772169057154,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.17888.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000}}],"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust through an Intermediate Fellowship in Public Health and Tropical Medicine","award":["100011\/Z\/12\/Z"],"award-info":[{"award-number":["100011\/Z\/12\/Z"]}]},{"name":"United States President\u2019s Malaria Initiative, and the U.S. Agency for International Development, under the terms of an Interagency Agreement with the Centers for Disease Control and Prevention"},{"name":"Republic of Senegal"}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background<\/ns3:bold>\n                    <ns3:bold>:<\/ns3:bold>\n                    Seasonal malaria chemoprevention (SMC) has been adopted and implemented in the southern regions of Senegal in children aged between three and 120 months since 2013. Scaling up this strategy requires its evaluation to assess the impact. This study was carried out to determine the dynamics of\n                    <ns3:italic>Plasmodium falciparum<\/ns3:italic>\n                    carriage before and after two years of SMC implementation.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods<\/ns3:bold>\n                    <ns3:bold>:<\/ns3:bold>\n                    Four household surveys were conducted in villages in the health district of Saraya, which is a SMC implementation area in Senegal. These villages were selected using probability proportional to size sampling. Each selected village was divided into segments containing at least 50 children. In each segment, a household questionnaire was administered to the parents or legal representatives of children aged three to 120 months. Blood smears were collected to determine\n                    <ns3:italic>P<\/ns3:italic>\n                    .\n                    <ns3:italic>falciparum<\/ns3:italic>\n                    prevalence by microscopy one month before the first round of SMC, one month after the last round of the first SMC campaign and two years after the start of the implementation.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results<\/ns3:bold>\n                    <ns3:bold>:<\/ns3:bold>\n                    A total of 2008 children were included with a mean average age of 4.81 (+\/-2.73) years. Of the study population, 50.33% were more than five years old and 50.3% were male. In 2013, mosquito net ownership was 99.4 % before the SMC campaign and 97.4% after. In 2015, it was 36.6% before and 45.8% after the campaign. In 2013, the prevalence of plasmodium carriage was 11.8% before and 6.1% after the SMC campaign. In 2015, the prevalence was 4.9% before the administration of SMC and this increased up to 15.3% after. Malaria prevalence was high among children over five years old and in boys.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions<\/ns3:bold>\n                    <ns3:bold>:<\/ns3:bold>\n                    The decrease in\n                    <ns3:italic>Plasmodium falciparum<\/ns3:italic>\n                    parasite prevalence, which subsequently increased after two years of SMC implementation in this study, suggests adding an extra cycle of the SMC or adjusting the administration period.\n                  <\/ns3:p>","DOI":"10.12688\/wellcomeopenres.17888.2","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T09:15:08Z","timestamp":1665479708000},"page":"179","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Malaria parasite carriage before and two years after the implementation of seasonal malaria chemoprevention: a case study of the Saraya health district, southern Senegal"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-4296","authenticated-orcid":false,"given":"Isaac Akhenaton","family":"Manga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou Sarifou","family":"BA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-4278","authenticated-orcid":false,"given":"Fassiatou","family":"Tairou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadou","family":"Seck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-0704","authenticated-orcid":false,"given":"Ekoue","family":"Kouevidjin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Sow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3896-6997","authenticated-orcid":false,"given":"Khadime","family":"Sylla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magatte","family":"Ndiaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatou","family":"Ba Fall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alioune Babara","family":"Gueye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahima","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9doune","family":"Ndiop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mady","family":"Ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Cl\u00e9ment","family":"Tine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Gaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babacar","family":"Faye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-5551","authenticated-orcid":false,"given":"Jean Louis Abdourahim","family":"Ndiaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"5489","DOI":"10.1038\/s41598-018-23878-2","article-title":"Implementation, coverage and equity of large-scale door-to-door delivery of Seasonal Malaria Chemoprevention (SMC) to children under 10 in Senegal.","volume":"8","author":"E 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Guide de terrain.","year":"2013"},{"key":"ref-10","article-title":"Malaria prevalence before and 2 years after implementation of seasonal malaria chemoprevention in Saraya, Senegal.","author":"I Manga","year":"2022","journal-title":"Zenodo."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"e1002762","DOI":"10.1371\/journal.pmed.1002762","article-title":"Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial.","volume":"16","author":"J Ndiaye","year":"2019","journal-title":"PLoS Med."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1186\/s12936-021-03953-2","article-title":"Prevalence of malaria in an area receiving seasonal malaria chemoprevention in Niger.","volume":"20","author":"M Coldiron","year":"2021","journal-title":"Malar J."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12936-015-0808-y","article-title":"A molecular survey of acute febrile illnesses reveals Plasmodium vivax infections in Kedougou, southeastern Senegal.","volume":"14","author":"M Niang","year":"2015","journal-title":"Malar J."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12936-016-1661-3","article-title":"Evidence of non-Plasmodium falciparum malaria infection in K\u00e9dougou, S\u00e9n\u00e9gal.","volume":"16","author":"R Daniels","year":"2017","journal-title":"Malar J."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"535-43","DOI":"10.1093\/cid\/cix355","article-title":"Safety and Efficacy of Adding a Single Low Dose of Primaquine to the Treatment of Adult Patients With Plasmodium falciparum Malaria in Senegal, to Reduce Gametocyte Carriage: A Randomized Controlled Trial.","volume":"65","author":"R Tine","year":"2017","journal-title":"Clin Infect Dis."}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T12:00:30Z","timestamp":1690459230000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":15,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.17888.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.20462.r52752","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20462.r61245","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20462.r61245","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.20462.r52752","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,11]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.20462.r52752, Innocent Mbulli Ali, MARCAD Program, The Biotechnology Centre, University of Yaound\u00e9 1, Yaound\u00e9, 24 Nov 2022, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2#referee-response-52752","order":0,"name":"referee-response-52752","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.20462.r61245, Benoit Malleret, National University of Singapore, Singapore, 27 Jul 2023, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-179\/v2#referee-response-61245","order":1,"name":"referee-response-61245","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [100011, <a href=https:\/\/doi.org\/10.35802\/100011>https:\/\/doi.org\/10.35802\/100011<\/a>]; an Intermediate Fellowship award in Public Health and Tropical Medicine to JLN]; the United States President\u2019s Malaria Initiative, and the U.S. Agency for International Development, under the terms of an Interagency Agreement with the Centers for Disease Control and Prevention (CDC) [JLN]; the Republic of Senegal (Ministry of Health\/National Malaria Control Program) [JLN].\n\nThe opinions expressed herein are those of the authors and do not necessarily reflect the views of the funders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}