{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:29:30Z","timestamp":1793136570388,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.18394.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000}}],"reference-count":28,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014338","name":"National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care Yorkshire and Humber","doi-asserted-by":"publisher","award":["NIHR200166"],"award-info":[{"award-number":["NIHR200166"]}],"id":[{"id":"10.13039\/501100014338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013529","name":"National Lottery Community Fund","doi-asserted-by":"publisher","award":["10094849"],"award-info":[{"award-number":["10094849"]}],"id":[{"id":"10.13039\/501100013529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["101597"],"award-info":[{"award-number":["101597"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    The Born in Bradford\u2019s Better Start (BiBBS) interventional birth cohort study was designed as an innovative cohort platform for efficient evaluation of early life interventions delivered through the Better Start Bradford programme. There are a growing number of interventional cohorts being implemented internationally. This paper provides an interim analysis of BiBBS in order to share learning about the feasibility and value of this method.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    Recruitment began in January 2016 and will complete in December 2023 with a target sample of 5,000 pregnancies. An interim analysis was completed for all pregnancies recruited between January 2016 and November 2019 with an expected due date between 1\n                    <ns4:sup>st<\/ns4:sup>\n                    April 2016 and 8\n                    <ns4:sup>th<\/ns4:sup>\n                    March 2020. Descriptive statistics were completed on the data.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Of 4,823 eligible pregnancies, 2,626 (54%) pregnancies were recruited, resulting in 2,392 mothers and 2,501 children. The sample are representative of the pregnant population (61% Pakistani heritage; 12% White British; 8% other South Asian and 6% Central and Eastern European ethnicity). The majority of participants (84%) live in the lowest decile of the Index of Multiple Deprivation, and many live in vulnerable circumstances. A high proportion (85%) of BiBBS families have engaged in one or more of the Better Start Bradford interventions. Levels of participation varied by the characteristics of the interventions, such as the requirement for active participation and the length of commitment to a programme.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    \u00a0We have demonstrated the feasibility of recruiting an interventional cohort that includes seldom heard families from ethnic minority and deprived backgrounds. The high level of uptake of interventions is encouraging for the goal of evaluating the process and outcomes of multiple early life interventions using the innovative interventional cohort approach. BiBBS covers a period before, during and after the coronavirus disease 2019 (COVID-19) pandemic which adds scientific value to the cohort.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.18394.2","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T10:41:13Z","timestamp":1695292873000},"page":"244","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Born in Bradford\u2019s Better Start (BiBBS) interventional birth cohort study: Interim cohort profile"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0121-3406","authenticated-orcid":false,"given":"Josie","family":"Dickerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9378-0055","authenticated-orcid":false,"given":"Sally","family":"Bridges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Willan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-7768","authenticated-orcid":false,"given":"Rachael H.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandani","family":"Netkitsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa K.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanora P.","family":"Uphoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-9216","authenticated-orcid":false,"given":"Dan","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Newsham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Waiblinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat","family":"Razaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-4098","authenticated-orcid":false,"given":"Maria","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-9995","authenticated-orcid":false,"given":"Sarah L.","family":"Blower","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8066-8507","authenticated-orcid":false,"given":"Kate E.","family":"Pickett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-6675","authenticated-orcid":false,"given":"Rosemary M.","family":"McEachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-7293","authenticated-orcid":false,"given":"John","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref-1","article-title":"The best start for life: a vision for the 1,001 critical 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Understanding the barriers to the recording and capture of perinatal mental ill health data: a mixed methods study.","author":"K Pybus"},{"key":"ref-31","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2019-000479","article-title":"Implementation evaluation of multiple complex early years interventions: an evaluation framework and study protocol.","volume":"3","author":"N Dharni","year":"2019","journal-title":"BMJ Paediatr Open."}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T11:00:17Z","timestamp":1696935617000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":28,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.18394.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.22243.r67463","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/wellcomeopenres.22243.r67463","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.20389.r52774, Tomas Faresjo, Division of Community Medicine, Department of Health, Medicine and Care, Link\u00f6ping University, Link\u00f6ping, 17 Nov 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v1#referee-response-52774","order":0,"name":"referee-response-52774","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.22243.r67463, Joseph Murray, Federal University of Pelotas, Pelotas, 10 Oct 2023, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/7-244\/v2#referee-response-67463","order":1,"name":"referee-response-67463","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was supported by Wellcome [101597, <a href=https:\/\/doi.org\/10.35802\/101597>https:\/\/doi.org\/10.35802\/101597<\/a>]; and the National Lottery Community Fund (previously the Big Lottery Fund) as part of the A Better Start programme (Ref 10094849). The funder was not involved in the design of the study and collection, analysis, and interpretation of data or in writing the manuscript. JD, SB, RM, KP, JW are also supported by the NIHR Yorkshire and Humber Applied Research Collaboration (ARC-YH; Ref: NIHR200166, see https:\/\/www.arc-yh.nihr.ac.uk,). The views in this publication are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}