{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:12:14Z","timestamp":1772169134851,"version":"3.50.1"},"reference-count":29,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["222530"],"award-info":[{"award-number":["222530"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>Cerebral malaria (CM) remains a significant global health challenge with high morbidity and mortality. Malarial retinopathy has been shown to be diagnostically and prognostically significant in the assessment of CM. The major mechanism of death in paediatric CM is brain swelling. Long term morbidity is typically characterised by neurological and neurodevelopmental sequelae. Optical coherence tomography can be used to quantify papilloedema and macular ischaemia, identified as hyperreflectivity.<\/ns4:p>\n                  <ns4:p>Here we describe a protocol to test the hypotheses that quantification of optic nerve head swelling using optical coherence tomography can identify severe brain swelling in CM, and that quantification of hyperreflectivity in the macula predicts neurodevelopmental outcomes post-recovery. Additionally, our protocol includes the development of a novel, low-cost, handheld optical coherence tomography machine and artificial intelligence tools to assist in image analysis.<\/ns4:p>","DOI":"10.12688\/wellcomeopenres.19166.1","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T06:50:06Z","timestamp":1681455006000},"page":"172","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting Acute and Post-Recovery Outcomes in Cerebral Malaria and Other Comas by Optical Coherence Tomography (OCT in CM) \u2013 A protocol for an observational cohort study of Malawian children"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-7530","authenticated-orcid":false,"given":"Kyle 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.21246.r58802, Leonardo J M Carvalho, University of Campinas, Campinas, 14 Jul 2023, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-172\/v1#referee-response-58802","order":0,"name":"referee-response-58802","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.21246.r63453, Monique F Stins, Johns Hopkins School of Public Health, Baltimore, MD, 30 Aug 2023, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-172\/v1#referee-response-63453","order":1,"name":"referee-response-63453","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study is funded by the Wellcome Trust\u2019s Investigator Award in Science Programme (Grant Number: 222530\/Z\/21\/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}