{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:11:09Z","timestamp":1772169069661,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.20210.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000}}],"reference-count":17,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["220211"],"award-info":[{"award-number":["220211"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns3:p>\n                    Background\n                    <ns3:italic>Listeria monocytogenes<\/ns3:italic>\n                    is a food-borne pathogen that is a rare cause of bacteraemia and meningitis in immunosuppressed patients, and carries a high mortality rate. Cutaneous manifestations of listeriosis are rare, and are usually associated with direct inoculation of the skin. Case A 41-year-old woman who initially presented to a hospital in Laos with appendicitis was diagnosed with disseminated listeriosis with cutaneous involvement. Intra-abdominal pathology probably contributed to bacterial bloodstream invasion. Initial treatment with meropenem was switched to ampicillin based on best practice, however our patient died 5 days after diagnosis. Conclusions This case highlights listeriosis as an important cause of mortality in low- and middle-income countries, exacerbated by poor availability of laboratory diagnostics and ineffective empiric antibiotic regimens. Improvements in food hygiene, surveillance, and increased laboratory capacity are important strategies to reduce rates of infection and clinical outcomes.\n                  <\/ns3:p>","DOI":"10.12688\/wellcomeopenres.20210.2","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:45:36Z","timestamp":1715769936000},"page":"504","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: A case of disseminated cutaneous listeriosis following appendicitis from Lao PDR"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-5197","authenticated-orcid":false,"given":"Terry John","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vannavong","family":"Siratana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Venkatesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viengmon","family":"Davong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khamphong","family":"Thanadabouth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-4822","authenticated-orcid":false,"given":"Elizabeth A.","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0014-2018","article-title":"Epidemiology and clinical manifestations of Listeria monocytogenes infection.","volume":"7","author":"W Schlech","year":"2019","journal-title":"Microbiol Spectr."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1073-1082","DOI":"10.1016\/S1473-3099(14)70870-9","article-title":"The global burden of listeriosis: a systematic review and meta-analysis.","volume":"14","author":"C de Noordhout","year":"2014","journal-title":"Lancet Infect Dis."},{"key":"ref-3","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1351983","article-title":"Antimicrobial resistance of Listeria monocytogenes from animal foods to first- and second-line drugs in the treatment of listeriosis from 2008 to 2021: a systematic review and meta-analysis.","volume":"2022","author":"J Dos Reis","year":"2022","journal-title":"Can J Infect Dis Med Microbiol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"771-783","DOI":"10.1016\/j.jiph.2023.03.013","article-title":"Mortality risk factors related to listeriosis - a meta-analysis.","volume":"16","author":"C Huang","year":"2023","journal-title":"J Infect Public Health."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"1236-43","DOI":"10.1016\/j.micinf.2007.05.011","article-title":"The epidemiology of human listeriosis.","volume":"9","author":"B Swaminathan","year":"2007","journal-title":"Microbes Infect."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"8-16","DOI":"10.1093\/cid\/ciab337","article-title":"Neonatal listeriosis presentation and outcome: a prospective study of 189 cases.","volume":"74","author":"C Charlier","year":"2022","journal-title":"Clin Infect Dis."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"3591-6","DOI":"10.1128\/JCM.01974-13","article-title":"Cutaneous listeriosis.","volume":"51","author":"C Godshall","year":"2013","journal-title":"J Clin Microbiol."},{"key":"ref-8","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab598","article-title":"Listeria-associated lymphadenitis: a series of 11 consecutive cases and review of the literature.","volume":"9","author":"M Blot","year":"2022","journal-title":"Open Forum Infect Dis."},{"key":"ref-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2018.e00430","article-title":"Listeria peritonitis and bacteremia in a patient with cholangiocarcinoma.","volume":"14","author":"M Eisa","year":"2018","journal-title":"IDCases."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"1973-1989","DOI":"10.1084\/jem.20170495","article-title":"Commensal microbes provide first line defense against Listeria monocytogenes infection.","volume":"214","author":"S Becattini","year":"2017","journal-title":"J Exp Med."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"510-519","DOI":"10.1016\/S1473-3099(16)30521-7","article-title":"Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study.","volume":"17","author":"C Charlier","year":"2017","journal-title":"Lancet Infect Dis."},{"key":"ref-12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009088","article-title":"Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations.","volume":"5","author":"N Sweiss","year":"2010","journal-title":"PLoS One."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"725-30","DOI":"10.1016\/j.cmi.2016.06.006","article-title":"Antibiotic treatment and mortality in patients with Listeria monocytogenes meningitis or bacteraemia.","volume":"22","author":"S Th\u00f8nnings","year":"2016","journal-title":"Clin Microbiol Infect."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"484-6","DOI":"10.1007\/s10096-004-1135-3","article-title":"Meropenem therapy failure in Listeria monocytogenes infection.","volume":"23","author":"S Stepanovi\u0107","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"123-5","DOI":"10.1007\/s10156-009-0014-3","article-title":"Antibiotic treatment for bacterial meningitis caused by Listeria monocytogenes in a patient with multiple myeloma.","volume":"16","author":"S Matano","year":"2010","journal-title":"J Infect Chemother."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"570-574","DOI":"10.53854\/liim-3104-16","article-title":"Brain abscesses caused by Listeria monocytogenes in a patient with myasthenia gravis - case report and systematic review.","volume":"31","author":"B Carneiro","year":"2023","journal-title":"Infez Med."},{"key":"ref-17","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2022.100417","article-title":"A systematic review and meta-analysis of the prevalence of Listeria monocytogenes in South-East Asia; a one-health approach of human-animal-food-environment.","volume":"15","author":"G Jibo","year":"2022","journal-title":"One Health."}],"container-title":["Wellcome Open Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T10:45:42Z","timestamp":1715769942000},"score":1,"resource":{"primary":{"URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":17,"URL":"https:\/\/doi.org\/10.12688\/wellcomeopenres.20210.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/wellcomeopenres.24013.r83372","asserted-by":"object"}]},"ISSN":["2398-502X"],"issn-type":[{"value":"2398-502X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.22379.r71636, Yvan Caspar, Bacteriology Laboratory, Institute of Biology and Pathology, CHU de Grenoble Alpes, Grenoble, 23 Jan 2024, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v1#referee-response-71636","order":0,"name":"referee-response-71636","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Terry Evans<\/b>; \n<i>Posted: 29 Feb 2024<\/i>; The authors thank the reviewer for his expert and thoughtful comments that clarify&nbsp;several important aspects of the presentation and treatment of this case.","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2#referee-comment-5624","order":1,"name":"referee-comment-5624","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.22379.r69858, Tengku Jamaluddin, Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, 20 Feb 2024, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v1#referee-response-69858","order":2,"name":"referee-response-69858","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.22379.r74088, Ioana Diana Olaru, Department of Clinical Research, University of M\u00fcnster, M\u00fcnster, 20 Feb 2024, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v1#referee-response-74088","order":3,"name":"referee-response-74088","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Terry Evans<\/b>; \n<i>Posted: 29 Feb 2024<\/i>; The authors appreciate the reviewer's careful and critical reading of our case. In this case, there was no history of unwell contacts. Patients' medical records are not computerized in our hospital, and therefore obtaining these results retrospectively can sometimes be challenging.","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v2#referee-comment-5625","order":4,"name":"referee-comment-5625","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.22379.r71633, Gauri Godbole, United Kingdom Health Security Agency, Gastrointestinal Pathogens and Food Safety (One Health) Division, London, 04 Mar 2024, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v1#referee-response-71633","order":5,"name":"referee-response-71633","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.22379.r74093, Bruno Hassunuma Carneiro, Federal University of Paran\u00e1, Curitiba, 29 Apr 2024, version 1, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/8-504\/v1#referee-response-74093","order":6,"name":"referee-response-74093","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [220211, <a href=https:\/\/doi.org\/10.35802\/220211>https:\/\/doi.org\/10.35802\/220211<\/a>], assigned to Professor Elizabeth Ashley. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":7,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}