{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T20:48:44Z","timestamp":1783198124995,"version":"3.54.6"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.20992.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000}}],"reference-count":28,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N024397\/1"],"award-info":[{"award-number":["MR\/N024397\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","award":["WT101597MA"],"award-info":[{"award-number":["WT101597MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031401","name":"UK Prevention Research Partnership","doi-asserted-by":"crossref","award":["MR\/S037527\/1"],"award-info":[{"award-number":["MR\/S037527\/1"]}],"id":[{"id":"10.13039\/100031401","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["CS\/16\/4\/32482"],"award-info":[{"award-number":["CS\/16\/4\/32482"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns5:p>Background Born in Bradford (BiB) is a family cohort study with linked routine health records. We calculated the rates of common health conditions and explored differences between White European and South Asian participants. Methods 21 health conditions were identified using diagnostic codes and prescription records extracted from electronic health records. We calculated 2-year period prevalence before recruitment and incidence rates per 1000 person-years were calculated from recruitment to the end of 2021 (or censoring). Age-adjusted Cox proportional hazard models estimated hazard ratios (HR) by ethnicity. Results The sample included 9,784 mothers, 52% were of South Asian heritage and 48% were White European. The highest prevalence and incidence rates were observed for common mental health disorders and eczema. South Asian women had higher incidence of 14 conditions, including diabetes (HR 3.94 [95% CI 3.15, 4.94]), chronic liver disease (2.98 [2.29, 3.88]) and thyroid disorders (1.87 [1.50, 2.33]), but lower incidence of cancer (0.51 [0.38, 0.68]), other and common mental health disorders (0.56 [0.45, 0.71] and 0.69 [0.64, 0.74] respectively), and other neuromuscular conditions (0.63 [0.49, 0.82]). Conclusions\/discussion This study reveals significant differences in the occurrence of several non-communicable health conditions between White European and South Asian women. The observed higher incidence of several conditions in South Asian women, consistent with established knowledge regarding elevated risks for diseases such as diabetes, likely reflects the complex interplay of social, cultural, lifestyle, environmental, and genetic determinants. These findings emphasise the need for culturally sensitive and targeted public health interventions aimed at addressing modifiable risk factors at both the individual and systemic levels to alleviate the burden of long-term health conditions and reduce existing health inequalities.<\/ns5:p>","DOI":"10.12688\/wellcomeopenres.20992.2","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:35:06Z","timestamp":1747391706000},"page":"210","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The emergence of common health conditions across the life course: evidence from the Born in Bradford family cohort"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-1783","authenticated-orcid":false,"given":"Gillian","family":"Santorelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnarajah","family":"Nirantharakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-5452","authenticated-orcid":false,"given":"Siang Ing","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-605X","authenticated-orcid":false,"given":"Katherine","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-6675","authenticated-orcid":false,"given":"Rosemary R.C.","family":"McEachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-7293","authenticated-orcid":false,"given":"John","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref-1","article-title":"Valuing health. Why prioritising population health is essential to prosperity","year":"2022"},{"key":"ref-2","doi-asserted-by":"publisher","DOI":"10.52768\/EpidemiolPublicHealth\/1030","article-title":"The relationship between ethnicity and socioeconomic deprivation as determinants of health: a systematic review.","volume":"2","author":"M Coates","year":"2024","journal-title":"Epidemiol Public Health."},{"key":"ref-3","article-title":"Saving lives, improving mothers care","year":"2024"},{"key":"ref-4","article-title":"Fingertips."},{"key":"ref-5","article-title":"2021 census: ethnic group, religion and language spoken.","year":"2022"},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"978-91","DOI":"10.1093\/ije\/dys112","article-title":"Cohort profile: the Born in Bradford multi-ethnic family cohort study.","volume":"42","author":"J Wright","year":"2013","journal-title":"Int J Epidemiol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12884-022-04442-3","article-title":"Epidemiology of pre-existing multimorbidity in pregnant women in the UK in 2018: a population-based cross-sectional study.","volume":"22","author":"S Lee","year":"2022","journal-title":"BMC Pregnancy Childbirth."},{"key":"ref-8","article-title":"Ethnic group statistics: a guide for the collection and classification of ethnicity data.","year":"2003"},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"453-61","DOI":"10.1192\/bjp.bp.114.158832","article-title":"Evaluation of ethnic disparities in detection of depression and anxiety in primary care during the maternal period: combined analysis of routine and cohort data.","volume":"208","author":"S Prady","year":"2016","journal-title":"Br J Psychiatry."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"452-67","DOI":"10.1080\/13557858.2015.1091442","article-title":"Social gradients in health for Pakistani and White British women and infants in two UK birth cohorts.","volume":"21","author":"E Uphoff","year":"2016","journal-title":"Ethn Health."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"113-127","DOI":"10.1007\/s00125-021-05580-7","article-title":"Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK.","volume":"65","author":"A Farmaki","year":"2022","journal-title":"Diabetologia."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"44-56","DOI":"10.1007\/s00125-022-05803-5","article-title":"Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data.","volume":"66","author":"S Iliodromiti","year":"2023","journal-title":"Diabetologia."},{"key":"ref-13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2023.100220","article-title":"Prevalence and associated factors for non-alcoholic fatty liver disease among adults in the South Asian Region: a meta-analysis.","volume":"15","author":"M Niriella","year":"2023","journal-title":"Lancet Reg Health Southeast Asia."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"236-246","DOI":"10.1111\/ppe.12719","article-title":"Maternal iodine status in a multi-ethnic UK birth cohort: associations with child cognitive and educational development.","volume":"35","author":"D Threapleton","year":"2021","journal-title":"Paediatr Perinat Epidemiol."},{"key":"ref-15","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab078","article-title":"Thyroid function during pregnancy in a multiethnic population in Norway.","volume":"5","author":"L Sletner","year":"2021","journal-title":"J Endocr Soc."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"1501-1512","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic 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and race.","author":"H Bradby","year":"2021"},{"key":"ref-21","article-title":"Ethnic inequalities in healthcare: a rapid evidence review","author":"D Kapdia","year":"2022"},{"key":"ref-22","article-title":"The health of people from ethnic minority groups in England.","author":"V Raleigh","year":"2021"},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"S8-S13","DOI":"10.5837\/bjc.2018.s08","article-title":"Diabetes and cardiovascular risk in UK South Asians: an overview.","volume":"25","author":"W Hanif","year":"2018","journal-title":"Br J Cardiol."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"144-147","DOI":"10.1111\/cea.13741","article-title":"Ethnicity-based differences in the incident risk of allergic diseases and autoimmune disorders: a UK-based retrospective cohort study of 4.4 million participants.","volume":"51","author":"A Subramanian","year":"2021","journal-title":"Clin Exp Allergy."},{"key":"ref-25","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02544-5","article-title":"Early onset of immune-mediated diseases in minority ethnic groups in the UK.","volume":"20","author":"A Sharma-Oates","year":"2022","journal-title":"BMC Med."},{"key":"ref-26","article-title":"PHE screening inequalities strategy","year":"2020"},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"o607","DOI":"10.1136\/bmj.o607","article-title":"Ethnic health inequalities in the NHS.","volume":"376","author":"K Patel","year":"2022","journal-title":"BMJ."},{"key":"ref-28","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15443.1","article-title":"ActEarly: a city collaboratory approach to early promotion of good health and wellbeing [version 1; peer review: 2 approved].","volume":"4","author":"J Wright","year":"2019","journal-title":"Wellcome Open Res."}],"container-title":["Wellcome Open 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.26688.r123716, Syed Masud Ahmed, BRAC University, Dhaka, Dhaka Division, 03 Jun 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/9-210\/v2#referee-response-123716","order":0,"name":"referee-response-123716","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.26688.r123717, Nusrat Husain, Division of Psychology & Mental Health, The University of Manchester, Manchester, 02 Jun 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/9-210\/v2#referee-response-123717","order":1,"name":"referee-response-123717","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Born in Bradford (BiB) receives core infrastructure funding from the Wellcome Trust (WT101597MA), and a joint grant from the UK Medical Research Council (MRC) and UK Economic and Social Science Research Council (ESRC) (MR\/N024397\/1) and one from the British Heart Foundation (BHF) (CS\/16\/4\/32482). The National Institute for Health Research Yorkshire and Humber ARC, and Clinical Research Network both provide support for BiB research. This work was also supported by the UK Prevention Research Partnership (MR\/S037527\/1), which is funded by the British Heart Foundation, Cancer Research UK, Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Health and Social Care Research and Development Division (Welsh Government), Medical Research Council, National Institute for Health Research, Natural Environment Research Council, Public Health Agency (Northern Ireland), The Health Foundation and Wellcome. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}