{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:13:06Z","timestamp":1772169186430,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.23556.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000}}],"reference-count":25,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["200841"],"award-info":[{"award-number":["200841"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns3:p>\n                    Background Prenatal infections are a leading cause of adverse pregnancy outcomes, yet the mechanisms underlying pathogen-specific effects on maternal and fetal health remain poorly understood. Methods Here we conducted a comparative analysis of four mouse models of prenatal infection:\n                    <ns3:italic>Toxoplasma gondii<\/ns3:italic>\n                    (intraperitoneal), vaccinia virus (intranasal), murine cytomegalovirus (intravenous) and influenza A virus (intranasal). Results We found markedly different effects on maternal morbidity and mortality, with\n                    <ns3:italic>T. gondii<\/ns3:italic>\n                    causing severe pregnancy-specific pathology leading to maternal mortality by 8 days post-infection, despite similar pathogen loads in pregnant and non-pregnant mice. Vaccinia virus caused prenatal morbidity, while cytomegalovirus and influenza induced only mild, transient effects. The maternal mortality in\n                    <ns3:italic>T.gondii<\/ns3:italic>\n                    infection was most likely due to immunopathology, while vaccinia virus caused prenatal morbidity possibly due to tissue infection. None of the pathogens directly infected the fetuses, yet both\n                    <ns3:italic>T. gondii<\/ns3:italic>\n                    and vaccinia virus significantly impaired both uterine vascular remodelling and fetal growth. Notably, pregnancy was found to be a modifier of local but not systemic immune responses, with reduced inflammatory cytokine production in uterine tissue of infected pregnant mice compared to non-pregnant controls. Conclusions These models provide a systematic platform for understanding pathogen-specific mechanisms of pregnancy complications and identifying therapeutic targets.\n                  <\/ns3:p>","DOI":"10.12688\/wellcomeopenres.23556.2","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T15:40:09Z","timestamp":1757432409000},"page":"142","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adverse maternal and fetal outcomes in mouse models of prenatal infections"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-2960","authenticated-orcid":false,"given":"Evgeniya","family":"V Shmeleva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2944-2908","authenticated-orcid":false,"given":"Delia","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7994-0598","authenticated-orcid":false,"given":"Cecilia","family":"Lusuardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Adewusi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5193-6376","authenticated-orcid":false,"given":"Francesco","family":"Colucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1071-1080","DOI":"10.1016\/S0140-6736(23)01198-4","article-title":"National, 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indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-142\/v2#referee-response-132863","order":2,"name":"referee-response-132863","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.27434.r132858, Rafaela Jos\u00e9 da Silva, Universidade Federal de Uberl\u00e2ndia, Uberl\u00e2ndia, 20 Oct 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-142\/v2#referee-response-132858","order":3,"name":"referee-response-132858","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.27434.r134140, eunha kim, Korea University College of Medicine, Seoul, Seoul, 29 Oct 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-142\/v2#referee-response-134140","order":4,"name":"referee-response-134140","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [200841; to FC]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}