{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:13:06Z","timestamp":1772169186512,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.23678.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000}}],"reference-count":78,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["223486"],"award-info":[{"award-number":["223486"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns3:p>Background Normal pressure hydrocephalus (NPH) is a potentially treatable condition causing dementia. Treatment is through insertion of a \u2018shunt\u2019, which improves symptoms and prolongs independence, but NPH may be under-treated. Automated brain imaging measures might have potential to identify NPH. Little is known about NPH presentation in memory clinics. This study investigates the period prevalence of NPH and potential use of imaging biomarkers for NPH, especially callosal angle (CA), in detecting NPH in UK memory services. Methods This cohort study will use retrospective data from South London and Maudsley Clinical Records Interactive Search and linked datasets. The study population will comprise individuals aged \u226560 years with at least one referral to memory services from 2007\u20132024 (estimated n&gt;20,000). Automated tools will be used to measure imaging biomarkers using routinely collected brain magnetic resonance imaging scans that are electronically linked to health records in a subset of the population (estimated n&gt;5,000). Results We will estimate the period prevalence of NPH in this population. We will evaluate automated measurement tools for imaging features of NPH, describe their distributions, and their variation by covariates (eg. demographics). We hypothesise that people with a diagnosis of NPH will have smaller CA compared to people with a diagnosis of dementia, and that imaging features of NPH will predict future diagnosis of NPH. Depending on our findings, we may undertake more detailed analyses, such as a nested case-control or survival analysis. Conclusions This study will give a first understanding of NPH in UK memory services. It will inform future work to improve identification of NPH, for example through a clinical decision support tool. With rising global dementia rates, research into this potentially treatable condition causing dementia is a priority.<\/ns3:p>","DOI":"10.12688\/wellcomeopenres.23678.2","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:15:10Z","timestamp":1760541310000},"page":"454","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A protocol for a cohort study investigating clinical and radiological features of normal pressure hydrocephalus in South London memory services"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-2678","authenticated-orcid":false,"given":"Clara","family":"Belessiotis-Richards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gill","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-1948","authenticated-orcid":false,"given":"Ashwin","family":"Venkataraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franti\u0161ek","family":"V\u00e1\u0161a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Smith-Wymant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sennett","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7010-2318","authenticated-orcid":false,"given":"Matthew","family":"Borzage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Leech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"307-27","DOI":"10.1016\/0022-510x(65)90016-x","article-title":"The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.27650.r136369, Tobias Langheinrich, Northern Care Alliance, Salford, 23 Oct 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-454\/v2#referee-response-136369","order":0,"name":"referee-response-136369","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.27650.r136370, John D Pickard, University of Cambridge Department of Physiology Development and Neuroscience, Cambridge, England, 25 Oct 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-454\/v2#referee-response-136370","order":1,"name":"referee-response-136370","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.27650.r136542, Masahiro Ohara, Tokyo Medical and Dental University, Tokyo, 03 Nov 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-454\/v2#referee-response-136542","order":2,"name":"referee-response-136542","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.27650.r136539, Kerstin Andren, University of Gothenburg, Gothenburg, 08 Nov 2025, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/10-454\/v2#referee-response-136539","order":3,"name":"referee-response-136539","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Wellcome [223486]. RS is part-funded by: i) the NIHR Maudsley Biomedical Research Centre at the South London and Maudsley NHS Foundation Trust and King\u2019s College London; ii) the National Institute for Health Research (NIHR) Applied Research Collaboration South London (NIHR ARC South London) at King\u2019s College Hospital NHS Foundation Trust; iii) UKRI \u2013 Medical Research Council through the DATAMIND HDR UK Mental Health Data Hub (MRC reference: MR\/W014386); iv) the UK Prevention Research Partnership (Violence, Health and Society; MR-VO49879\/1), an initiative funded by UK Research and Innovation Councils, the Department of Health and Social Care (England) and the UK devolved administrations, and leading health research charities. RL is funded by the NIHR Maudsley Biomedical Research Centre. AVV is funded by the National Institute for Health Research (NIHR) as NIHR Clinical Lecturer and supported by the NIHR Maudsley Biomedical Research Centre and the NIHR HealthTech Research Centre in Brain Health at King\u2019s College London and South London and Maudsley NHS Foundation Trust and King\u2019s College London (NQOD-04) as PI of SLaM Image Bank. GL is funded by UCL Hospitals NIHR Biomedical Research Centre, North Thames NIHR Applied Research Collaboration (ID1861414), and as an NIHR Senior Investigator  (NIHR201321). She is in receipt of grants from NIHR PGfAR (NIHR202345 and NIHR203670), the Alzheimer\u2019s Association and Brain Canada (ARCOM-22\u2013875327), the Norwegian Research Council (ES637280), Wellcome (UNS114095 00222932\/Z\/21\/Z), Geller Foundation, and UK MRC 7512758 UKRI ES\/Y011139\/1. FV is funded by a NIHR Biomedical Research Centre Early Career Investigator Award and by the Bill and Melinda Gates Foundation UNITY project [INV-032788; INV-047888]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}