{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:48:39Z","timestamp":1782366519584,"version":"3.54.5"},"reference-count":80,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["CC2223"],"award-info":[{"award-number":["CC2223"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospital For Tropical Diseases Charity Funding, London"},{"name":"National Institute for Health and Care Research University College London Hospital Biomedical Research Centre","award":["BRC1190\/III\/PM\/101350"],"award-info":[{"award-number":["BRC1190\/III\/PM\/101350"]}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns5:p>Background Chronic viral hepatitis infections (hepatitis B (HBV), C (HCV) and D viruses (HDV)) are responsible for over 1 million deaths annually, due to cirrhosis and liver cancer. Mongolia has a high prevalence of all these infections, resulting in the highest incidence and mortality from liver cancer in the world. Other factors, such as metabolic dysfunction-associated steatotic liver disease (MASLD) can impact viral hepatitis, although the interaction is not fully understood. Several successful viral hepatitis screening programmes have been carried out among Mongolians living in Spain, USA, and Sweden. Protocol We describe a community-informed protocol for the implementation of liver health screening among Mongolians living in London (UK), designed by a multi-disciplinary team. This observational, mixed-methods study (\u2018Hep-MoLo\u2019) has three domains. (i) In the clinical domain, liver screening events will be held in London, in collaboration with the Mongolian Community Organisation. An awareness-raising educational component will precede point-of-care screening for blood-borne infections (HBV, HCV, HIV), liver fibrosis and steatosis, and screening for cardiometabolic risk factors (obesity, hypertension, dyslipidaemia, diabetes); (ii) Laboratory studies will focus on the interaction between HBV and MASLD; (iii) A qualitative approach will be used to explore community views on liver health screening, access and engaging in care. Discussion This protocol provides a framework for a public health intervention targeting a high-risk population, combined with laboratory and qualitative research to give a multi-dimensional insight into viral hepatitis and liver health in the London Mongolian community. This is a community-academic-clinical partnership, fostering collaboration to generate data to inform clinical and public health interventions.<\/ns5:p>","DOI":"10.12688\/wellcomeopenres.25134.1","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T18:09:08Z","timestamp":1769191748000},"page":"72","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Viral hepatitis and liver disease in the Mongolian community in London ('MoLo'): A mixed methods study protocol to investigate the epidemiology and burden of disease to inform clinical and public health interventions"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-9298","authenticated-orcid":false,"given":"Emily","family":"Martyn","sequence":"first","affiliation":[{"name":"London England The Francis Crick Institute"},{"name":"Division of Infection and Immunity London England University College London Faculty of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nara","family":"Dashdorj","sequence":"additional","affiliation":[{"name":"Ulaanbaatar Ulaanbaatar Onom Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Carter","sequence":"additional","affiliation":[{"name":"Migrant Health Research Group, Institute for Infection and Immunity London City St George's University of London"},{"name":"Queen Mary's Univesity of London London England Wolfson Institute of Population Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5311-9885","authenticated-orcid":false,"given":"Indrajit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Hepatitis Service, Mortimer Market Centre London England Central and North West London NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enkh-Oyun","family":"Amarbayasgalan","sequence":"additional","affiliation":[{"name":"London Mongolian Community Organisation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-7290","authenticated-orcid":false,"given":"Khadija","family":"Said Mohammed","sequence":"additional","affiliation":[{"name":"London England The Francis Crick Institute"},{"name":"Division of Biosciences London England University College London Faculty of Life Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Waddilove","sequence":"additional","affiliation":[{"name":"London England The Francis Crick Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Delphin","sequence":"additional","affiliation":[{"name":"London England The Francis Crick 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The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}