{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:06:20Z","timestamp":1791252380375,"version":"4.1.0"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRR"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1269\/jrr.10039","type":"journal-article","created":{"date-parts":[[2010,8,30]],"date-time":"2010-08-30T05:20:17Z","timestamp":1283145617000},"page":"493-501","source":"Crossref","is-referenced-by-count":54,"title":["Involvement of DNA-PK and ATM in Radiation- and Heat-induced DNA Damage Recognition and Apoptotic Cell Death"],"prefix":"10.1093","volume":"51","author":[{"given":"Masanori","family":"TOMITA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"1","unstructured":"1. Hall EJ and Giaccia AJ (2006) DNA strand breaks and chromosomal aberrations. In: Radiobiology for the Radiologist. 6th ed. pp. 16-29, Lippincott; Philadelphia."},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/85798"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/35056049"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.07130"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080413"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00201-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2438"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90482-4"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00061-1"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200030200"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.8.2038"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110295"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/35088000"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.065615"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01800-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02366-06"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01232-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.8.2858-2866.2001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80202-6"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.029"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Lavin MF and Khanna KK (1999) ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. Int J Radiat Biol <b>75<\/b>: 1201-1214.","DOI":"10.1080\/095530099139359"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Shiloh Y (2001) ATM and ATR: networking cellular responses to DNA damage. Curr Opin Genet Dev <b>11<\/b>: 71-77.","DOI":"10.1016\/S0959-437X(00)00159-3"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Lavin MF and Kozlov S (2007) ATM activation and DNA damage response. Cell Cycle <b>6<\/b>: 931-942.","DOI":"10.4161\/cc.6.8.4180"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Savitsky K, <i>et al<\/i> (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science <b>268<\/b>: 1749-1753.","DOI":"10.1126\/science.7792600"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1140321"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/nature01368"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601231"},{"issue":"12","key":"28","first-page":"3299","volume":"60","author":"GATEI M","year":"2000","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/35007091"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/35013083"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/35013089"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.10.029"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Jeggo PA and Lobroch M (2005) Artemis links ATM to double-strand break rejoining. Cell Cycle <b>4<\/b>: 359-362.","DOI":"10.4161\/cc.4.3.1527"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Evan GI and Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature <b>411<\/b>: 342-348.","DOI":"10.1038\/35077213"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.08065"},{"key":"36","unstructured":"36. Minowada J, Ohmura T and Moore GE (1972) Rosette-forming human lymphoid cell lines. 1. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst <b>49<\/b>: 891-895."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Shinohara K and Nakano H (1993) Interphase death and reproductive death in X-irradiated MOLT-4 cells. Radiat Res <b>135<\/b>: 197-205.","DOI":"10.2307\/3578295"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Nakano H and Shinohara K (1999) Correlation between unirradiated cell TP53 protein levels and radiosensitivity in MOLT-4 cells. Radiat Res <b>151<\/b>: 686-693.","DOI":"10.2307\/3580207"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3860"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00422-5"},{"issue":"2","key":"41","first-page":"246","volume":"56","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"19","key":"42","first-page":"4375","volume":"58","author":"SARKARIA J N","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981123)78:5<642::AID-IJC19>3.0.CO;2-3"},{"key":"44","unstructured":"44. Rosenzweig KE, <i>et al<\/i> (1997) Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. Clin Cancer Res <b>3<\/b>: 1149-1156."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Boulton S, <i>et al<\/i> (1996) Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis <b>17<\/b>: 2285-2290.","DOI":"10.1093\/carcin\/17.11.2285"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Okayasu R, Suetomi K and Ullrich RL (1998) Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Radiat Res <b>149<\/b>: 440-445.","DOI":"10.2307\/3579783"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00221-3"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Chernikova SB, Wells RL and Elkind MM (1999) Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks. Radiat Res <b>151<\/b>: 159-166.","DOI":"10.2307\/3579766"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Tomita M, <i>et al<\/i> (2003) Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK\/SAPK Pathway. Radiat Res <b>160<\/b>: 467-477.","DOI":"10.1667\/RR3055"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1038\/21913"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.22.2905"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202570"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Ohyama H and Yamada T (1998) Radiation-induced apoptosis: A review. In: Apoptosis. Its roles and mechanism. pp. 141-186, Business center for academic societies Japan; Tokyo.","DOI":"10.1007\/978-3-642-72082-6_8"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Dbaibo GS, <i>et al<\/i> (1998) p53-dependent ceramide response to genotoxic stress. J Clin Invest <b>102<\/b>: 329-339.","DOI":"10.1172\/JCI1180"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80143-9"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110062512"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Enomoto A, <i>et al<\/i> (2008) Negative regulation of MEKK1\/2 signaling by Serine-Threonine kinase 38 (STK38). Oncogene <b>27<\/b>: 1930-1938.","DOI":"10.1038\/sj.onc.1210828"},{"issue":"24","key":"58","first-page":"5991","volume":"55","year":"1995","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"6","key":"59","first-page":"1400","volume":"56","year":"1996","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"15","key":"60","first-page":"3242","volume":"55","year":"1995","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202571"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80769-2"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207087"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17908"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1584"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Abe T, <i>et al<\/i> (2008) KU70\/80, DNA-PKcs and Artemis are essential for the rapid induction of apoptosis massive DSB formation. Cell Signal <b>20<\/b>: 1978-1985.","DOI":"10.1016\/j.cellsig.2008.07.006"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204497"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.214"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2008.06.013"},{"key":"70","unstructured":"70. Hall EJ and Giaccia AJ (2006) Hyperthermia. In: Radiobiology for the Radiologist. 6th ed. pp. 469-490, Lippincott; Philadelphia."},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Li GC, Evans RG and Hahn GM (1976) Modification and inhibition of repair of potentially lethal X-ray damage by hyperthermia. Radiat Res <b>67<\/b>: 491-501.","DOI":"10.2307\/3574345"},{"issue":"5","key":"72","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0360-3016(92)90804-Q","volume":"22","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/0360-3016","issn-type":"print"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Mivechi NF and Dewey WC (1985) DNA polymerase &alpha; and &beta; activities during the cell cycle and their role in heat radiosensitization in Chinese hamster ovary cells. Radiat Res <b>103<\/b>: 337-350.","DOI":"10.2307\/3576756"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Corry PM, Robinson S and Getz S (1977) Hyperthermic effects on DNA repair mechanisms. Radiology <b>123<\/b>: 475-482.","DOI":"10.1148\/123.2.475"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Christophi C, <i>et al<\/i> (1999) The treatment of malignancy by hyperthermia. Surg Oncol <b>7<\/b>: 83-90.","DOI":"10.1016\/S0960-7404(99)00007-9"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6689"},{"issue":"14","key":"77","first-page":"2847","volume":"57","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1080\/095530099140717"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.21.14988"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138385"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.41.93"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.3109\/02656739509022483"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1269\/jrr.09111"},{"issue":"11","key":"84","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/0360-3016(82)90454-0","volume":"8","author":"Raaphorst, G. P. and Azzam, E. I.","year":"1982","ISSN":"https:\/\/id.crossref.org\/issn\/0360-3016","issn-type":"print"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Mitchel RE, <i>et al<\/i> (1984) The effects of hyperthermia and ionizing radiation in normal and ataxia telangiectasia human fibroblast lines. Radiat Res <b>99<\/b>: 627-635.","DOI":"10.2307\/3576336"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13084"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1038\/nature05112"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.3109\/02656739409010282"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514551041"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Raaphorst GP, Ng CE and Yang DP (1999) Thermal radiosensitization and repair inhibition in human melanoma cells: a comparison of survival and DNA double strand breaks. Int J Hyperthermia <b>15<\/b>: 17-27.","DOI":"10.1080\/026567399285828"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1080\/02656730701769841"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1876"},{"issue":"1-2","key":"93","first-page":"88","volume":"656","author":"TAKAHASHI AKIHISA","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/0027-5107","issn-type":"print"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.073"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4328"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.24.14510"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201210"},{"issue":"4","key":"98","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1128\/MCB.19.4.2828","volume":"19","author":"NAKAGAWA K","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/51\/5\/493\/2700965\/jrr-51-493.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T16:39:24Z","timestamp":1636303164000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article-lookup\/doi\/10.1269\/jrr.10039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":98,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1269\/jrr.10039","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}