{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:50:13Z","timestamp":1774122613318,"version":"3.50.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JRR"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1269\/jrr.11035","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T01:21:41Z","timestamp":1328145701000},"page":"10-17","source":"Crossref","is-referenced-by-count":64,"title":["Angiotensin Converting Enzyme Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax"],"prefix":"10.1093","volume":"53","author":[{"given":"Lakhan","family":"KMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"GAO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"FISH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"MOULDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R.","family":"JACOBS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meetha","family":"MEDHORA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"1","unstructured":"1. Fliedner TM, Dorr HD and Meineke V (2005) Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. BJR Suppl <b>27<\/b>: 1-8."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Haston CK, <i>et al<\/i> (2007) Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Res <b>67<\/b>: 10796-10803.","DOI":"10.1158\/0008-5472.CAN-07-2733"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kong FM, <i>et al<\/i> (2005) Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis. Semin Oncol <b>32<\/b>: S42-S54.","DOI":"10.1053\/j.seminoncol.2005.03.009"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.047"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00095-G"},{"key":"6","unstructured":"6. Wu CT, <i>et al<\/i> (2009) Androgen deprivation modulates the inflammatory response induced by irradiation. BMC Cancer <b>9<\/b>: 92."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Han G, <i>et al<\/i> (2006) Angelica sinensis down-regulates hydroxyproline and Tgfb1 and provides protection in mice with radiation-induced pulmonary fibrosis. Radiat Res <b>165<\/b>: 546-552.","DOI":"10.1667\/RR3543.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lee JC, <i>et al<\/i> (2009) Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol Ther <b>8<\/b>: 47-53.","DOI":"10.4161\/cbt.8.1.7092"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Vujaskovic Z, <i>et al<\/i> (2002) A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med <b>33<\/b>: 857-863.","DOI":"10.1016\/S0891-5849(02)00980-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Vujaskovic Z, <i>et al<\/i> (2002) Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. Radiat Res <b>157<\/b>: 656-660.","DOI":"10.1667\/0033-7587(2002)157[0656:ROLBAI]2.0.CO;2"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Calveley VL, <i>et al<\/i> (2010) Genistein can mitigate the effect of radiation on rat lung tissue. Radiat Res <b>173<\/b>: 602-611.","DOI":"10.1667\/RR1896.1"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Molteni A, <i>et al<\/i> (2000) Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int J Radiat Biol <b>76<\/b>: 523-532.","DOI":"10.1080\/095530000138538"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Molteni A, <i>et al<\/i> (2007) Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis. Curr Pharm Des <b>13<\/b>: 1307-1316.","DOI":"10.2174\/138161207780618777"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ghosh SN, <i>et al<\/i> (2009) Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys <b>75<\/b>: 1528-1536.","DOI":"10.1016\/j.ijrobp.2009.07.1743"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Zhang R, <i>et al<\/i> (2008) Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. Int J Radiat Biol <b>84<\/b>: 487-497.","DOI":"10.1080\/09553000802078396"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Szabo S, <i>et al<\/i> (2010) Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. Radiat Res <b>173<\/b>: 545-556.","DOI":"10.1667\/RR1753.1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ghosh SN, <i>et al<\/i> (2009) Vascular injury after whole thoracic x-ray irradiation in the rat. Int J Radiat Oncol Biol Phys <b>74<\/b>: 192-199.","DOI":"10.1016\/j.ijrobp.2009.01.006"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kagaya Y, <i>et al<\/i> (1996) Long-term angiotensin-converting enzyme inhibition with fosinopril improves depressed responsiveness to Ca2+ in myocytes from aortic-banded rats. Circulation <b>94<\/b>: 2915-2922.","DOI":"10.1161\/01.CIR.94.11.2915"},{"issue":"11","key":"19","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/ajhp\/55.11.1155","volume":"55","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1079-2082","issn-type":"print"},{"issue":"3","key":"20","first-page":"612","volume":"49","year":"1992","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9289","issn-type":"print"},{"key":"21","unstructured":"21. Sosnowska K, Winnicka K and Czajkowska-Kosnik A (2009) Stability of extemporaneous enalapril maleate suspensions for pediatric use prepared from commercially available tablets. Acta Pol Pharm <b>66<\/b>: 321-326."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chalkley SM, <i>et al<\/i> (2002) Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats. Am J Physiol Endocrinol Metab <b>282<\/b>: E1231-E1238.","DOI":"10.1152\/ajpendo.00173.2001"},{"key":"23","unstructured":"23. Stone HB, <i>et al<\/i> (2004) Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res <b>162<\/b>: 711-728."},{"key":"24","unstructured":"24. Moulder JE and Medhora M (2011). Advances in mitigation of injury from radiological terrorism or nuclear accidents. Defense Sci J <b>61<\/b>: 99-104."},{"key":"25","unstructured":"25. van Rongen E, Tan C and Zurcher C (1986) Early and late effects of fractionated irradiation of the thorax of WAG\/Rij rats. Br J Cancer Suppl <b>7<\/b>: 333-335."},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0360-3016(80)90145-5","volume":"6","year":"1980","ISSN":"https:\/\/id.crossref.org\/issn\/0360-3016","issn-type":"print"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0379TR"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Robbins ME and Diz DI (2006) Pathogenic role of the renin-angiotensin system in modulating radiation-induced late effects. Int J Radiat Oncol Biol Phys <b>64<\/b>: 6-12.","DOI":"10.1016\/j.ijrobp.2005.08.033"},{"issue":"10","key":"29","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/jn\/128.10.1661","volume":"128","author":"REDLICH C A","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3166","issn-type":"print"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.007"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90541-Q"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. van Rongen E, Tan CH and Durham SK (1987) Late functional, biochemical and histological changes in the rat lung after fractionated irradiation to the whole thorax. Radiother Oncol <b>10<\/b>: 231-246.","DOI":"10.1016\/S0167-8140(87)80009-9"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Cushman DW, <i>et al<\/i> (1989) Differentiation of angiotensin-converting enzyme (ACE) inhibitors by their selective inhibition of ACE in physiologically important target organs. Am J Hypertens <b>2<\/b>: 294-306.","DOI":"10.1093\/ajh\/2.4.294"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Williams JP, <i>et al<\/i> (2010) Animal models for medical countermeasures to radiation exposure. Radiat Res <b>173<\/b>: 557-578.","DOI":"10.1667\/RR1880.1"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Sharplin J and Franko AJ (1989) A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res <b>119<\/b>: 1-14.","DOI":"10.2307\/3577363"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Johnston CJ, <i>et al<\/i> (1998) Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation. Exp Lung Res <b>24<\/b>: 321-337.","DOI":"10.3109\/01902149809041538"}],"container-title":["Journal of Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jrr\/article-pdf\/53\/1\/10\/2706914\/jrr-53-10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:39:17Z","timestamp":1561250357000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jrr\/article-lookup\/doi\/10.1269\/jrr.11035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1269\/jrr.11035","relation":{},"ISSN":["0449-3060","1349-9157"],"issn-type":[{"value":"0449-3060","type":"print"},{"value":"1349-9157","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}