{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:43:46Z","timestamp":1789152226457,"version":"build-2803163510"},"reference-count":27,"publisher":"Yeungnam University College of Medicine","content-domain":{"domain":["e-jyms.org"],"crossmark-restriction":true},"short-container-title":["J Yeungnam Med Sci"],"abstract":"<jats:p>Background: Chronic periodontitis is associated with various systemic inflammatory diseases; however, research on its association with chronic kidney disease (CKD) is relatively limited. Because both conditions share common risk factors, systemic inflammation plays a key role in the progression of these diseases. Galectin-3 (Gal-3) is a proinflammatory cytokine that plays an important role in chronic inflammatory diseases and is a potential biomarker. This study aimed to measure salivary Gal-3 levels in patients with periodontitis and CKD to better understand their association and evaluate Gal-3 as a diagnostic biomarker for these conditions.Methods: Seventy-five patients were categorized into three groups: Group I, patients with CKD and periodontitis (n=25); Group II, patients with chronic periodontitis who were systemically healthy (n=25); and Group III, patients with CKD without chronic periodontitis (n=25). Demographic characteristics and periodontal and renal parameters were recorded for each patient. Saliva samples were collected to evaluate Gal-3 levels using an enzyme-linked immunosorbent assay.Results: Patients with chronic periodontitis and CKD and those with chronic periodontitis alone (Groups I and II, respectively) showed significantly higher salivary Gal-3 levels than patients with CKD alone (Group III) (&lt;i&gt;p&lt;\/i&gt;&lt;0.001). Bivariate correlation analysis indicated a strong relationship between clinical parameters and Gal-3 levels across all three groups.Conclusion: Salivary Gal-3 level is a valuable early diagnostic marker of chronic periodontitis and CKD.<\/jats:p>","DOI":"10.12701\/jyms.2025.42.22","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:30:32Z","timestamp":1737419432000},"page":"22","update-policy":"https:\/\/doi.org\/10.12701\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Galectin-3 as a possible link between periodontitis and chronic kidney disease: a cross-sectional study"],"prefix":"10.12701","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5071-8358","authenticated-orcid":true,"given":"Sri 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