{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:06:48Z","timestamp":1780038408038,"version":"3.53.1"},"reference-count":19,"publisher":"Yeungnam University College of Medicine","content-domain":{"domain":["e-jyms.org"],"crossmark-restriction":true},"short-container-title":["J Yeungnam Med Sci"],"abstract":"<jats:p>Background: Clopidogrel requires several hours to achieve adequate platelet inhibition. We investigated the association of clopidogrel preloading time with 30-day clinical outcomes and post-procedural troponin elevation in patients with stable angina undergoing elective percutaneous coronary intervention (PCI).Methods: This single-center retrospective cohort study included 1,020 patients with stable angina (clopidogrel-naive) who received 300 mg clopidogrel preloading within 24 hours before elective PCI between 2012 and 2020. Patients were categorized according to clopidogrel preloading-to-balloon time \u22646 hours or &gt;6 hours. The primary endpoint was 30-day major adverse cardiovascular events (MACE), defined as a composite of all-cause death, myocardial infarction, stroke, and any revascularization. Secondary endpoints included serial troponin T changes and troponin T elevation \u22655\u00d7, \u226525\u00d7, and \u226570\u00d7 the upper reference limit. Stabilized inverse probability of treatment weighting (IPTW) was used.Results: Thirty-day MACE occurred in five patients (0.49%) and did not differ between the \u22646-hour and &gt;6-hour groups after IPTW (0.5% vs. 0.4%, p=0.754). Post-procedural troponin T levels at 6, 24, and 48 hours were higher in the \u22646-hour group. Patients with shorter preloading-to-balloon times showed higher peak troponin T levels, with the greatest difference at the \u22641-hour cutoff (geometric mean ratio, 2.12; 95% confidence interval, 1.53\u20132.95; p&lt;0.001) and progressive attenuation at longer cutoffs. Troponin T elevation \u22655\u00d7 and \u226525\u00d7 was more frequent in the \u22646-hour group, whereas \u226570\u00d7 elevation did not differ.Conclusion: Clopidogrel preloading \u22646 hours before elective PCI was not associated with increased 30-day MACE but was associated with lower-threshold post-procedural troponin T elevation.<\/jats:p>","DOI":"10.12701\/jyms.2026.43.34","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:06:08Z","timestamp":1779167168000},"page":"34","update-policy":"https:\/\/doi.org\/10.12701\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between clopidogrel preloading time and post-procedural troponin elevation in patients with stable angina undergoing elective percutaneous coronary intervention: a retrospective cohort 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