{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:44:30Z","timestamp":1791477870773,"version":"4.3.4"},"reference-count":0,"publisher":"Faculty Opinions Ltd","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fac Rev"],"abstract":"<jats:p>Severe vitamin D deficiency\u201425-hydroxyvitamin D (25OHD) concentrations below around 25\u201330 nmol\/L\u2014may lead to growth plate disorganization and mineralization abnormalities in children (rickets) and mineralization defects throughout the skeleton (osteomalacia) and proximal muscle weakness. Both problems are reversed with vitamin D treatment. Apart from this musculoskeletal dysfunction at very low vitamin D levels, there is apparent inconsistency in the available data about whether concentrations of 25OHD below around 50 nmol\/L cause muscle function impairment and increase the risk of fracture. This narrative review provides evidence to support the contention that improving vitamin D status, up to around 50 nmol\/L, plays a small causal role in optimizing bone and muscle function as well as reducing overall mortality.<\/jats:p>","DOI":"10.12703\/r\/9-19","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T20:48:56Z","timestamp":1607028536000},"source":"Crossref","is-referenced-by-count":5,"title":["Is it reasonable to ignore vitamin D status for musculoskeletal health?"],"prefix":"10.12703","volume":"9","author":[{"given":"Rebecca S","family":"Mason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Rybchyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara C","family":"Brennan-Speranza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4950","published-online":{"date-parts":[[2020,12,3]]},"container-title":["Faculty Reviews"],"original-title":[],"deposited":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T20:48:57Z","timestamp":1607028537000},"score":1,"resource":{"primary":{"URL":"https:\/\/facultyopinions.com\/prime\/reports\/b\/9\/19\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.12703\/r\/9-19","relation":{},"ISSN":["2732-432X"],"issn-type":[{"value":"2732-432X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]}}}