{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:03:28Z","timestamp":1791810208254,"version":"4.3.4"},"reference-count":38,"publisher":"Korean Society of Developmental Biology","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ012-26502"],"award-info":[{"award-number":["PJ012-26502"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ksdb.org"],"crossmark-restriction":true},"short-container-title":["Dev Reprod"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.12717\/dr.2017.21.2.157","type":"journal-article","created":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:15:30Z","timestamp":1501460130000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.12717\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Production and Breeding of Transgenic Cloned Pigs Expressing Human\n                    CD73"],"prefix":"10.12717","volume":"21","author":[{"given":"Seung-Chan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haesun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon Bong","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Sul","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ryung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-A","family":"Ock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seok","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Sun","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongsoo","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5022","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"key2.0170731130849e+13_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2013.00194","article-title":"Purinergic signaling in inflammatory renal\n                        disease","volume":"4","author":"Arulkumaran","year":"2013","journal-title":"Front Physiol"},{"key":"key2.0170731130849e+13_B2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1681\/ASN.2009121217","article-title":"Adenosine generation and signaling during acute kidney\n                        injury","volume":"22","author":"Bauerle","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"key2.0170731130849e+13_B3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nm1330","article-title":"Acute rejection is associated with antibodies to non-Gal antigens\n                        in baboons using Gal-knockout pig kidneys","volume":"11","author":"Chen","year":"2005","journal-title":"Nat Med"},{"key":"key2.0170731130849e+13_B4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11248-016-9996-7","article-title":"Production of heterozygous alpha 1,3-galactosyltransferase\n                        (GGTA1) knock-out transgenic miniature pigs expressing human\n                        CD39","volume":"26","author":"Choi","year":"2017","journal-title":"Transgenic Res"},{"key":"key2.0170731130849e+13_B5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1399-3089.2012.00708.x","article-title":"Clinical lung xeno-transplantation-- what donor genetic\n                        modifications may be necessary?","volume":"19","author":"Cooper","year":"2012","journal-title":"Xenotransplantation"},{"key":"key2.0170731130849e+13_B6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/icb.2008.107","article-title":"Complement activation and coagulation in\n                        xenotransplantation","volume":"87","author":"Cowan","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"key2.0170731130849e+13_B7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1399-3089.2006.00368.x","article-title":"Coagulation and the xenograft endothelium","volume":"14","author":"Cowan","year":"2007","journal-title":"Xenotransplantation"},{"key":"key2.0170731130849e+13_B8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/01.tp.0000238721.88920.ee","article-title":"Intravascular thrombosis in discordant\n                        xenotransplantation","volume":"82","author":"Crikis","year":"2006","journal-title":"Transplantation"},{"key":"key2.0170731130849e+13_B9","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0024-3205(91)90043-B","article-title":"Physiological and pharmacological properties of adenosine:\n                        therapeutic implications","volume":"49","author":"Daval","year":"1991","journal-title":"Life Sci"},{"key":"key2.0170731130849e+13_B10","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1002\/eji.200323566","article-title":"Endothelial cell cytoprotection induced in vitro by allo- or\n                        xenoreactive antibodies is mediated by signaling through adenosine A2\n                        receptors","volume":"33","author":"Delikouras","year":"2003","journal-title":"Eur J Immunol"},{"key":"key2.0170731130849e+13_B11","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(11)61091-X","article-title":"Clinical xenotransplantation: the next medical revolution?","volume":"379","author":"Ekser","year":"2012","journal-title":"Lancet"},{"key":"key2.0170731130849e+13_B12","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/mrd.20890","article-title":"Production of alpha 1,3-galactosyltransferase gene-deficient pigs\n                        by somatic cell nuclear transfer: a novel selection method for gal alpha\n                        1,3-Gal antigen-deficient cells","volume":"75","author":"Fujimura","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"key2.0170731130849e+13_B13","first-page":"s72","article-title":"Long-term survival of pig-to-primate renal xenotransplant using\n                        costimulation-blockade immunosuppressio","author":"Higginbotham"},{"key":"key2.0170731130849e+13_B14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1399-3089.2004.00155.x","article-title":"Thrombotic microangiopathy and graft arteriopathy in pig hearts\n                        following transplantation into baboons","volume":"11","author":"Houser","year":"2004","journal-title":"Xenotransplantation"},{"key":"key2.0170731130849e+13_B15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12717\/DR.2015.19.2.079","article-title":"Production of cloned Korean native pig by somatic cell nuclear\n                        transfer","volume":"19","author":"Hwang","year":"2015","journal-title":"Dev Reprod"},{"key":"key2.0170731130849e+13_B16","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/xen.12174","article-title":"Pig kidney graft survival in a baboon for 136 days: longest\n                        lifesupporting organ graft survival to date","volume":"22","author":"Iwase","year":"2015","journal-title":"Xenotransplantation"},{"key":"key2.0170731130849e+13_B17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbadis.2005.03.008","article-title":"Loss of ecto-50 nucleotidase from porcine endothelial cells after\n                        exposure to human blood: implications for\n                        xenotransplantation","volume":"1741","author":"Khalpey","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"key2.0170731130849e+13_B18","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1016\/j.transproceed.2013.08.049","article-title":"Outcomes of alpha 1,3-GT-knockout porcine heart transplants into\n                        a preclinical nonhuman primate model","volume":"45","author":"Kim","year":"2013","journal-title":"Transplant Proc"},{"key":"key2.0170731130849e+13_B19","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1073\/pnas.0307819101","article-title":"Production of alpha-1,3-galactosyl-transferase null pigs by means\n                        of nuclear transfer with fibroblasts bearing loss of heterozygosity\n                        mutations","volume":"101","author":"Kolber-Simonds","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key2.0170731130849e+13_B20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm1171","article-title":"Heart transplantation in baboons using alpha\n                        1,3-galactosyltransferase gene-knockout pigs as donors: initial\n                        experience","volume":"11","author":"Kuwaki","year":"2005","journal-title":"Nat Med"},{"key":"key2.0170731130849e+13_B21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11248-016-9979-8","article-title":"Generation of \u03b1-1,3-galactosyltransferase knocked-out transgenic\n                        cloned pigs with knocked-in five human genes","volume":"26","author":"Kwon","year":"2017","journal-title":"Transgenic Res"},{"key":"key2.0170731130849e+13_B22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00007890-199809150-00001","article-title":"Discordant organ xenotransplantation in primates: world\n                        experience and current status","volume":"66","author":"Lambrigts","year":"1998","journal-title":"Transplantation"},{"key":"key2.0170731130849e+13_B23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1439-0531.2010.01670.x","article-title":"Characterization of transgenic pigs that express human decay\n                        accelerating factor and cell membrane-tethered human tissue factor pathway\n                        inhibitor","volume":"46","author":"Lee","year":"2011","journal-title":"Reprod Domest Anim"},{"key":"key2.0170731130849e+13_B24","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.jss.2012.06.035","article-title":"Biallelic knockout of the alpha-1,3 galactosyltransferase gene in\n                        porcine liver-derived cells using zinc finger nucleases","volume":"181","author":"Li","year":"2013","journal-title":"J Surg Res"},{"key":"key2.0170731130849e+13_B25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.trim.2008.10.008","article-title":"Coagulation dysregulation as a barrier to xenotransplantation in\n                        the primate","volume":"21","author":"Lin","year":"2009","journal-title":"Transpl Immunol"},{"key":"key2.0170731130849e+13_B26","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1600-6143.2010.03147.x","article-title":"Recipient tissue factor expression is associated with consumptive\n                        coagulopathy in pig-to-primate kidney xenotransplantation","volume":"10","author":"Lin","year":"2010","journal-title":"Am J Transplant"},{"key":"key2.0170731130849e+13_B27","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1097\/01.TP.0000147302.64947.43","article-title":"Cardiac xenotransplantation: progress toward the\n                        clinic","volume":"78","author":"McGregor","year":"2004","journal-title":"Transplantation"},{"key":"key2.0170731130849e+13_B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11138","article-title":"Chimeric 2C10R4 anti-CD40 antibody therapy is critical for\n                        long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac\n                        xenograft","volume":"7","author":"Mohiuddin","year":"2016","journal-title":"Nat Commun"},{"key":"key2.0170731130849e+13_B29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1399-3089.2007.00417.x","article-title":"Production of homozygous alpha-1,3-galactosyltransferase knockout\n                        pigs by breeding and somatic cell nuclear transfer","volume":"14","author":"Nottle","year":"2007","journal-title":"Xenotransplantation"},{"key":"key2.0170731130849e+13_B30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.12750\/JET.2016.31.3.161","article-title":"Production of porcine fibroblasts carrying a vector enforced\n                        specific expression of CD73 to endothelial cells","volume":"31","author":"Oh","year":"2016","journal-title":"J Emb Trans"},{"key":"key2.0170731130849e+13_B31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1126\/science.1078942","article-title":"Production of alpha 1,3-galactosyltransferase-deficient\n                        pigs","volume":"299","author":"Phelps","year":"2003","journal-title":"Science"},{"key":"key2.0170731130849e+13_B32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1600-065X.2003.00090.x","article-title":"Effector mechanisms in transplant rejection","volume":"196","author":"Rocha","year":"2003","journal-title":"Immunol Rev"},{"key":"key2.0170731130849e+13_B33","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2353\/ajpath.2008.070672","article-title":"Thrombotic microangiopathy associated with humoral rejection of\n                        cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in\n                        baboons","volume":"172","author":"Shimizu","year":"2008","journal-title":"Am J Pathol"},{"key":"key2.0170731130849e+13_B34","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.22.012703.104731","article-title":"Physiological control of immune response and inflammatory tissue\n                        damage by hypoxia-inducible factors and adenosine A2A\n                        receptors","volume":"22","author":"Sitkovsky","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"key2.0170731130849e+13_B35","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.tp.0000181397.41143.fa","article-title":"alpha 1,3-Galactosyltransferase gene-knockout pig heart\n                        transplantation in baboons with survival approaching 6\n                        months","volume":"80","author":"Tseng","year":"2005","journal-title":"Transplantation"},{"key":"key2.0170731130849e+13_B36","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.yjmcc.2012.01.002","article-title":"Transgenic swine: expression of human CD39 protects against\n                        myocardial injury","volume":"52","author":"Wheeler","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"key2.0170731130849e+13_B37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.thromres.2007.05.022","article-title":"Platelet aggregation and thrombosis in xenotransplantation\n                        between pigs and humans","volume":"121","author":"Zhang","year":"2008","journal-title":"Thromb Res"},{"key":"key2.0170731130849e+13_B38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/(SICI)1098-2299(199611\/12)39:3\/4<337::AID-DDR15>3.0.CO;2-Z","article-title":"Extracellular purine metabolism","volume":"39","author":"Zimmermann","year":"1996","journal-title":"Drug Dev Res"}],"container-title":["Development &amp; Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?pid=dr-21-2-157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?pid=dr-21-2-157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:16:37Z","timestamp":1501460197000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ksdb.org\/archive\/view_article?pid=dr-21-2-157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,30]]},"published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.12717\/DR.2017.21.2.157"],"URL":"https:\/\/doi.org\/10.12717\/dr.2017.21.2.157","relation":{},"ISSN":["2465-9525","2465-9541"],"issn-type":[{"value":"2465-9525","type":"print"},{"value":"2465-9541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2017-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}