{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:28:26Z","timestamp":1768516106382,"version":"3.49.0"},"reference-count":47,"publisher":"Korean Society of Developmental Biology","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015M3A9D7067365"],"award-info":[{"award-number":["NRF-2015M3A9D7067365"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["H16C1085"],"award-info":[{"award-number":["H16C1085"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ksdb.org"],"crossmark-restriction":true},"short-container-title":["Dev. Reprod."],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.12717\/dr.2018.22.4.379","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T05:20:35Z","timestamp":1548220835000},"page":"379-391","update-policy":"https:\/\/doi.org\/10.12717\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chronic Low-Dose Nonylphenol or Di-(2-ethylhexyl) Phthalate has a\n                    Different Estrogen-like Response in Mouse Uterus"],"prefix":"10.12717","volume":"22","author":[{"given":"Juhye","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunyeong","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Jeong","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunhyeok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongsuk","family":"Ryou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Il","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Pil","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5022","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"key2.0190123105643e+13_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/187152206775528833","article-title":"Reproductive and endocrine effects of p-nonylphenol and\n                        methoxychlor: a review","volume":"6","author":"Bandiera","year":"2006","journal-title":"Immun Endoc Metab Agents Med Chem"},{"key":"key2.0190123105643e+13_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/54.1.138","article-title":"The estrogen receptor relative binding affinities of 188 natural\n                        and xenochemicals: Structural diversity of ligands","volume":"54","author":"Blair","year":"2000","journal-title":"Toxicol Sci"},{"key":"key2.0190123105643e+13_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.reprotox.2018.08.016","article-title":"Development of a curated Hershberger database","volume":"81","author":"Browne","year":"2018","journal-title":"Reprod Toxicol"},{"key":"key2.0190123105643e+13_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tox.2017.07.017","article-title":"Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)\n                        induces an obesogenic effect in C57BL\/6J mice fed a high fat\n                        diet","volume":"390","author":"Brulport","year":"2017","journal-title":"Toxicology"},{"key":"key2.0190123105643e+13_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine disruptors: From endocrine to metabolic\n                        disruption","volume":"73","author":"Casals-Casas","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"key2.0190123105643e+13_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.12717\/DR.2017.21.2.121","article-title":"Disturbing effects of chronic low-dose 4-nonylphenol exposing on\n                        gonadal weight and reproductive outcome over one-generation","volume":"21","author":"Cha","year":"2017","journal-title":"Dev Reprod"},{"key":"key2.0190123105643e+13_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.12717\/DR.2018.22.1.085","article-title":"Nonmonotinic effects of chronic low-dose di (2-ethylhexyl)\n                        phthalate on gonadal weight and reproductive","volume":"22","author":"Cha","year":"2018","journal-title":"Dev Reprod"},{"key":"key2.0190123105643e+13_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1679\/aohc.67.417","article-title":"Role of stromal-epithelial interactions in hormonal\n                        response","volume":"67","author":"Cunha","year":"2004","journal-title":"Arch Histol Cytol"},{"key":"key2.0190123105643e+13_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0890-6238(01)00194-0","article-title":"Effects of nonylphenol, 1,1-dichloro-2,2-bis\n                        (p-chlorophenyl) ethylene\n                        (p,p\u2032-DDE), and pentachlorophenol on the adult\n                        female guinea pig reproductive tract","volume":"16","author":"Danzo","year":"2002","journal-title":"Reprod Toxicol"},{"key":"key2.0190123105643e+13_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/taap.1994.1200","article-title":"Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in\n                        cycling rats","volume":"128","author":"Davis","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"key2.0190123105643e+13_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.taap.2018.04.007","article-title":"Chronic low-dose exposure of nonylphenol alters energy\n                        homeostasis in the reproductive system of female rats","volume":"348","author":"Di","year":"2018","journal-title":"Toxicol Appl Pharmacol"},{"key":"key2.0190123105643e+13_bib12","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.intimp.2008.09.002","article-title":"Detrimental effects of hyperandrogenism on uterine\n                        functions","volume":"8","author":"Elia","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"key2.0190123105643e+13_bib13","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1210\/en.2002-0143","article-title":"Response-specific and ligand dose-dependent modulation of\n                        estrogen receptor (ER) alpha activity by ERbeta in the\n                        uterus","volume":"144","author":"Frasor","year":"2003","journal-title":"Endocrinology"},{"key":"key2.0190123105643e+13_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/toxsci\/kfj128","article-title":"A dose-response study following in utero and lactational exposure\n                        to di (2-ethylhexyl) phthalate: Effects on female rat reproductive\n                        development","volume":"91","author":"Grande","year":"2006","journal-title":"Toxicol Sci"},{"key":"key2.0190123105643e+13_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/joe.0.1690023","article-title":"Proliferation, mitosis orientation and morphogenetic changes in\n                        the uterus of mice following chronic treatment with both estrogen and\n                        glucocorticoid hormones","volume":"169","author":"Gunin","year":"2001","journal-title":"J Endocrinol"},{"key":"key2.0190123105643e+13_bib16","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.4161\/15384101.2014.943581","article-title":"Expression, regulation and function of Egr1 during implantation\n                        and decidualization in mice","volume":"13","author":"Guo","year":"2014","journal-title":"Cell Cycle"},{"key":"key2.0190123105643e+13_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev.publhealth.012809.103714","article-title":"Plastics and health risks","volume":"31","author":"Halden","year":"2010","journal-title":"Annu Rev Public Health"},{"key":"key2.0190123105643e+13_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.brainresrev.2007.05.006","article-title":"Estrogen positive feedback to gonadotropin-releasing hormone\n                        (GnRH) neurons in the rodent: The case for the rostral periventricular area\n                        of the third ventricle (RP3V)","volume":"57","author":"Herbison","year":"2008","journal-title":"Brain Res Rev"},{"key":"key2.0190123105643e+13_bib19","doi-asserted-by":"crossref","first-page":"e96781","DOI":"10.1371\/journal.pone.0096781","article-title":"Maternal cypermethrin exposure during the perinatal period\n                        impairs testicular development in C57BL male offspring","volume":"9","author":"Huang","year":"2014","journal-title":"PLOS ONE"},{"key":"key2.0190123105643e+13_bib20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.etap.2017.11.008","article-title":"Evidence for estrogeno-mimetic effects of a mixture of low-dose\n                        pollutants in a model of ovariectomized mice","volume":"57","author":"Julien","year":"2018","journal-title":"Environ Toxicol Pharmacol"},{"key":"key2.0190123105643e+13_bib21","first-page":"1","volume-title":"Environmental Endocrine Disruptors: A Handbook of Property Data","author":"Keith","year":"1997"},{"key":"key2.0190123105643e+13_bib22","first-page":"4972","article-title":"Analysis of the in vitro effects of di\u2011(2\u2011ethyl-\n                        hexyl) phthalate exposure on human uterine leiomyoma cells","volume":"15","author":"Kim","year":"2018","journal-title":"Exp Ther Med"},{"key":"key2.0190123105643e+13_bib23","first-page":"1","volume-title":"Hormonal Chaos: The Scientific and Social Origins of the Environmental\n                        Endocrine Hypothesis","author":"Krimsky","year":"2000"},{"key":"key2.0190123105643e+13_bib24","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Iteraction of estrogenic chemicals and phytoestrogens with\n                        estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"key2.0190123105643e+13_bib25","volume-title":"Ullmann's Encyclopedia of Industrial Chemistry","author":"Lorz","year":"2007"},{"key":"key2.0190123105643e+13_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1289\/ehp.5658","article-title":"Mechanisms of phthalate ester toxicity in the female reproductive\n                        system","volume":"111","author":"Lovekamp-Swan","year":"2003","journal-title":"Environ Health Perspect"},{"key":"key2.0190123105643e+13_bib27","first-page":"e56771","article-title":"Long-term behavioral and reproductive consequences of embryonic\n                        exposure to low-dose toxicants","volume":"133","author":"Mersha","year":"2018","journal-title":"J Vis Exp"},{"key":"key2.0190123105643e+13_bib28","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.277.5331.1508","article-title":"Differential ligand activation of estrogen receptors ERalpha and\n                        ERbeta at AP1 sites","volume":"277","author":"Paech","year":"1997","journal-title":"Science"},{"key":"key2.0190123105643e+13_bib29","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/56.2.332","article-title":"Bisphenol A-induced increase in uterine weight and alterations in\n                        uterine morphology in ovariectomized B6C3F1 mice: Role of the estrogen\n                        receptor","volume":"56","author":"Papaconstantinou","year":"2000","journal-title":"Toxicol Sci"},{"key":"key2.0190123105643e+13_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/02757549408038554","article-title":"Estrogenic effects of effluents from sewage treatment\n                        works","volume":"8","author":"Purdom","year":"1994","journal-title":"Chem Ecol"},{"key":"key2.0190123105643e+13_bib31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/toxsci\/kfv163","article-title":"Impact of low-dose oral exposure to bisphenol A (BPA) on juvenile\n                        and adult rat exploratory and anxiety behavior: A CLARITY-BPA consortium\n                        study","volume":"148","author":"Rebuli","year":"2015","journal-title":"Toxicol Sci"},{"key":"key2.0190123105643e+13_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.reprotox.2018.01.006","article-title":"Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and\n                        uterine gl and numbers in the uteri of adult exposed mice","volume":"77","author":"Richardson","year":"2018","journal-title":"Reprod Toxicol"},{"key":"key2.0190123105643e+13_bib33","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1248\/jhs.47.495","article-title":"Several environmental pollutants have binding affinities for both\n                        androgen receptor and estrogen receptor \u03b1","volume":"47","author":"Satoh","year":"2001","journal-title":"J Health Sci"},{"key":"key2.0190123105643e+13_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.repbio.2016.09.001","article-title":"Impact of endocrine disrupting chemicals on onset and development\n                        of female reproductive disorders and hormone-related cancer","volume":"16","author":"Scsukova","year":"2016","journal-title":"Reprod Biol"},{"key":"key2.0190123105643e+13_bib35","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1289\/ehp.961041296","article-title":"Assessing environmental chemicals for estrogenicity using a\n                        combination of in vitro and in vivo assays","volume":"104","author":"Shelby","year":"1996","journal-title":"Environ Health Perspect"},{"key":"key2.0190123105643e+13_bib36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.envint.2008.01.004","article-title":"Nonylphenol in the environment: A critical review on occurrence,\n                        fate, toxicity and treatment in wastewaters","volume":"34","author":"Soares","year":"2008","journal-title":"Environ Int"},{"key":"key2.0190123105643e+13_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuro.2014.09.008","article-title":"Sex-specific enhanced and behavioral toxicity induced by maternal\n                        exposure to a mixture of low dose endocrine-disrupting\n                        chemicals","volume":"45","author":"Sobolewski","year":"2014","journal-title":"Nerurotoxicology"},{"key":"key2.0190123105643e+13_bib38","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/0960327116657601","article-title":"Impact of di-(2-ethylhexyl) phthalate on the uterus of adult\n                        Wistar rats","volume":"36","author":"Somasundaram","year":"2016","journal-title":"Hum Exp Toxicol"},{"key":"key2.0190123105643e+13_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1289\/ehp.9192167","article-title":"p-nonyl-phenol: An estrogenic xenobiotic released from\n                        \u201cmodified\u201d polystyrene","volume":"92","author":"Soto","year":"1991","journal-title":"Environ Health Perspect"},{"key":"key2.0190123105643e+13_bib40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.tox.2005.02.002","article-title":"Differential effects of phthalate esters on transcriptional\n                        activities via human estrogen receptors alpha and beta, and androgen\n                        receptor","volume":"210","author":"Takeuchi","year":"2005","journal-title":"Toxicology"},{"key":"key2.0190123105643e+13_bib41","volume-title":"What is endocrine disruption?","author":"USEPA","year":"2017"},{"key":"key2.0190123105643e+13_bib42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: Low-dose effects and\n                        nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"key":"key2.0190123105643e+13_bib43","doi-asserted-by":"crossref","first-page":"7494","DOI":"10.1038\/s41598-018-25831-9","article-title":"Gestational oral low-dose estradiol-17\u03b2 induces altered\n                        DNA methylation of CDKN2D and PSAT1 in embryos and adult\n                        offspring","volume":"8","author":"van der Weijden","year":"2018","journal-title":"Sci Rep"},{"key":"key2.0190123105643e+13_bib44","doi-asserted-by":"crossref","first-page":"18350","DOI":"10.1073\/pnas.0608861103","article-title":"Role of estrogen receptor beta in uterine stroma and epithelium:\n                        Insights from estrogen receptor beta\u2013\/\u2013\n                        mice","volume":"103","author":"Wada-Hiraike","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"key2.0190123105643e+13_bib45","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1073\/pnas.97.11.5936","article-title":"Estrogen receptor (ER) beta, a modulator of ERalpha in the\n                        uterus","volume":"97","author":"Weihua","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key2.0190123105643e+13_bib46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1095\/biolreprod.112.104802","article-title":"Targeted genome-wide methylation and gene expression analyses\n                        reveal signaling pathways involved in ovarian dysfunction after\n                        developmental EDC exposure in rats","volume":"88","author":"Zama","year":"2013","journal-title":"Biol Reprod"},{"key":"key2.0190123105643e+13_bib47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tox.2007.08.089","article-title":"Comparative studies on the increase of uterine weight and related\n                        mechanisms of cadmium and p-nonylphenol","volume":"24","author":"Zhang","year":"2007","journal-title":"Toxicology"}],"container-title":["Development & Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2018.22.4.379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2018.22.4.379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T05:21:48Z","timestamp":1548220908000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ksdb.org\/archive\/view_article?doi=10.12717\/DR.2018.22.4.379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12,31]]},"published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.12717\/DR.2018.22.4.379"],"URL":"https:\/\/doi.org\/10.12717\/dr.2018.22.4.379","relation":{},"ISSN":["2465-9525","2465-9541"],"issn-type":[{"value":"2465-9525","type":"print"},{"value":"2465-9541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}