{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T11:26:57Z","timestamp":1744630017489,"version":"3.37.3"},"reference-count":22,"publisher":"Korean Society of Developmental Biology","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creative-commons.org\/licenses\/by-nc\/3.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M3A9B4065302"],"award-info":[{"award-number":["NRF-2017M3A9B4065302"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ksdb.org"],"crossmark-restriction":true},"short-container-title":["Dev. Reprod."],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.12717\/dr.2019.23.4.391","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T02:33:17Z","timestamp":1580178797000},"page":"391-399","update-policy":"https:\/\/doi.org\/10.12717\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["SIRT1 Knockdown Enhances the Differentiation of Human Embryonic Stem Cells into Pancreatic \u03b2 Cells"],"prefix":"10.12717","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-8713","authenticated-orcid":false,"given":"Nan-Hee","family":"Seo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-7120","authenticated-orcid":false,"given":"Hwa-Ryung","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-9778","authenticated-orcid":false,"given":"Myung-Kwan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5022","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"key2.0200128054152e+13_ref1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.molcel.2005.02.022","article-title":"Mechanism of sirtuin inhibition by nicotinamide: Altering the NAD(+) cosubstrate specificity of a Sir2 enzyme","volume":"17","author":"Avalos","year":"2005","journal-title":"Mol Cell"},{"key":"key2.0200128054152e+13_ref2","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1126\/science.329.5995.1012","article-title":"Dietary restriction: Standing up for sirtuins","volume":"329","author":"Baur","year":"2010","journal-title":"Science"},{"key":"key2.0200128054152e+13_ref3","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/j.1600-6143.2011.03977.x","article-title":"Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes","volume":"12","author":"Bellin","year":"2012","journal-title":"Am J Transplant"},{"key":"key2.0200128054152e+13_ref4","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pbio.0040031","article-title":"Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells","volume":"4","author":"Bordone","year":"2006","journal-title":"PLOS Biol"},{"key":"key2.0200128054152e+13_ref5","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1474-9726.2010.00548.x","article-title":"Aging and disease: Connections to sirtuins","volume":"9","author":"Donmez","year":"2010","journal-title":"Aging Cell"},{"key":"key2.0200128054152e+13_ref6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1582-4934.2004.tb00471.x","article-title":"Embryonic stem cells: A promising tool for cell replacement therapy","volume":"8","author":"Doss","year":"2004","journal-title":"J Cell Mol Med"},{"key":"key2.0200128054152e+13_ref7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: Biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"key2.0200128054152e+13_ref8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.stem.2008.01.002","article-title":"SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization","volume":"2","author":"Han","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key2.0200128054152e+13_ref9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat Biotechnol"},{"key":"key2.0200128054152e+13_ref10","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.freeradbiomed.2006.02.014","article-title":"Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation","volume":"40","author":"Kume","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"key2.0200128054152e+13_ref11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/00007890-198804000-00038","article-title":"A simple method of staining fresh and cultured islets","volume":"45","author":"Latif","year":"1988","journal-title":"Transplantation"},{"key":"key2.0200128054152e+13_ref12","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"key2.0200128054152e+13_ref13","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.biomaterials.2008.12.030","article-title":"The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells","volume":"30","author":"Mao","year":"2009","journal-title":"Biomaterials"},{"key":"key2.0200128054152e+13_ref14","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrm2189","article-title":"Embryonic stem-cell culture as a tool for developmental cell biology","volume":"8","author":"Nishikawa","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key2.0200128054152e+13_ref15","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.2337\/db11-1711","article-title":"Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice","volume":"61","author":"Rezania","year":"2012","journal-title":"Diabetes"},{"key":"key2.0200128054152e+13_ref16","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1242\/dev.127.24.5533","article-title":"Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas","volume":"127","author":"Sander","year":"2000","journal-title":"Development"},{"key":"key2.0200128054152e+13_ref17","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/MCB.01791-07","article-title":"Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1","volume":"28","author":"Schisler","year":"2008","journal-title":"Mol Cell Biol"},{"key":"key2.0200128054152e+13_ref18","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1126\/science.157.3789.697","article-title":"Insulin biosynthesis: Evidence for a precursor","volume":"157","author":"Steiner","year":"1967","journal-title":"Science"},{"key":"key2.0200128054152e+13_ref19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"key2.0200128054152e+13_ref20","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"key2.0200128054152e+13_ref21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","article-title":"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"key2.0200128054152e+13_ref22","doi-asserted-by":"crossref","first-page":"e72513","DOI":"10.1371\/journal.pone.0072513","article-title":"Insulin-producing cells derived from human embryonic stem cells: Comparison of definitive endoderm- and nestin-positive progenitor-based differentiation strategies","volume":"8","author":"Wei","year":"2013","journal-title":"PLOS ONE"}],"container-title":["Development &amp; Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2019.23.4.391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2019.23.4.391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T02:03:47Z","timestamp":1665626627000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ksdb.org\/archive\/view_article?doi=10.12717\/DR.2019.23.4.391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12,31]]},"published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.12717\/DR.2019.23.4.391"],"URL":"https:\/\/doi.org\/10.12717\/dr.2019.23.4.391","relation":{},"ISSN":["2465-9525","2465-9541"],"issn-type":[{"type":"print","value":"2465-9525"},{"type":"electronic","value":"2465-9541"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}