{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:09:16Z","timestamp":1776442156272,"version":"3.51.2"},"reference-count":26,"publisher":"Korean Society of Developmental Biology","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creative-commons.org\/licenses\/by-nc\/3.0"}],"funder":[{"DOI":"10.13039\/501100002555","name":"Seoul Women\u2019s University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ksdb.org"],"crossmark-restriction":true},"short-container-title":["Dev. Reprod."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.12717\/dr.2021.25.4.213","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T06:26:48Z","timestamp":1643264808000},"page":"213-223","update-policy":"https:\/\/doi.org\/10.12717\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Repeated Ovarian Stimulation on Ovarian Function and Aging\n                    in Mice"],"prefix":"10.12717","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-3481","authenticated-orcid":false,"given":"Jihye","family":"Whang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-4080","authenticated-orcid":false,"given":"Cheyoung","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-4899","authenticated-orcid":false,"given":"Soohyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-6270","authenticated-orcid":false,"given":"Eunji","family":"Seok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-0699","authenticated-orcid":false,"given":"Yunjeong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7701-3342","authenticated-orcid":false,"given":"Goeun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-1638","authenticated-orcid":false,"given":"Haeun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-647X","authenticated-orcid":false,"given":"Hyunwon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5022","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"key2.0220127073431e+13_ref1","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.fertnstert.2006.05.049","article-title":"Triggering ovulation with gonadotropin-releasing hormone agonists\n                        does not compromise embryo implantation rates","volume":"86","author":"Acevedo","year":"2006","journal-title":"Fertil Steril"},{"key":"key2.0220127073431e+13_ref2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1262\/jrd.2019-147","article-title":"Repeated hyperstimulation affects the ultrastructure of mouse\n                        fallopian tube epithelium","volume":"66","author":"Antonouli","year":"2020","journal-title":"J Reprod Dev"},{"key":"key2.0220127073431e+13_ref3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1098\/rspb.1963.0055","article-title":"A quantitative and cytological study of germ cells in human\n                        ovaries","volume":"158","author":"Baker","year":"1963","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"key2.0220127073431e+13_ref4","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1093\/humrep\/16.11.2320","article-title":"The effect of repeated controlled ovarian stimulation in\n                        donors","volume":"16","author":"Caligara","year":"2001","journal-title":"Hum Reprod"},{"key":"key2.0220127073431e+13_ref5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400978","article-title":"Mammalian target of rapamycin (mTOR): Pro- and\n                        anti-apoptotic","volume":"9","author":"Castedo","year":"2002","journal-title":"Cell Death Differ"},{"key":"key2.0220127073431e+13_ref6","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1093\/humrep\/15.12.2489","article-title":"Role of gonadotrophins and progesterone in the regulation of\n                        morphological remodelling and atresia in the monkey peri-ovulatory\n                        follicle","volume":"15","author":"Chaffin","year":"2000","journal-title":"Hum Reprod"},{"key":"key2.0220127073431e+13_ref7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1196\/annals.1338.016","article-title":"Repeated ovarian stimulations induce oxidative damage and\n                        mitochondrial DNA mutations in mouse ovaries","volume":"1042","author":"Chao","year":"2005","journal-title":"Ann NY Acad Sci"},{"key":"key2.0220127073431e+13_ref8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fnbeh.2020.00113","article-title":"The stage of the estrus cycle is critical for interpretation of\n                        female mouse social interaction behavior","volume":"14","author":"Chari","year":"2020","journal-title":"Front Behav Neurosci"},{"key":"key2.0220127073431e+13_ref9","first-page":"2135","article-title":"Follicle-stimulating hormone and luteinizing hormone\/chorionic\n                        gonadotropin stimulation of vascular endothelial growth factor production by\n                        macaque granulosa cells from pre- and periovulatory\n                        follicles","volume":"82","author":"Christenson","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key2.0220127073431e+13_ref10","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.fertnstert.2014.07.739","article-title":"Long-term effects of repeated superovulation on ovarian structure\n                        and function in rhesus monkeys","volume":"102","author":"Dong","year":"2014","journal-title":"Fertil Steril"},{"key":"key2.0220127073431e+13_ref11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-0030-1265676","article-title":"Ovarian hyperstimulation syndrome prevention strategies: Use of\n                        gonadotropin-releasing hormone antagonists","volume":"28","author":"Griesinger","year":"2010","journal-title":"Semin Reprod Med"},{"key":"key2.0220127073431e+13_ref12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/humrep\/dem408","article-title":"A new model of reproductive aging: The decline in ovarian\n                        non-growing follicle number from birth to menopause","volume":"23","author":"Hansen","year":"2008","journal-title":"Hum Reprod"},{"key":"key2.0220127073431e+13_ref13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0950-3552(98)80052-7","article-title":"4 Complications of ovarian stimulation","volume":"12","author":"Jacobs","year":"1998","journal-title":"Baillieres Clin Obstet Gynaecol"},{"key":"key2.0220127073431e+13_ref14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/cdd.2011.121","article-title":"Fas death receptor signalling: Roles of Bid and\n                        XIAP","volume":"19","author":"Kaufmann","year":"2012","journal-title":"Cell Death Differ"},{"key":"key2.0220127073431e+13_ref15","doi-asserted-by":"crossref","first-page":"e0232819","DOI":"10.1371\/journal.pone.0232819","article-title":"A dual death\/survival role of autophagy in the adult ovary of\n                            Lagostomus maximus (Mammalia-Rodentia)","volume":"15","author":"Leopardo","year":"2020","journal-title":"PLOS ONE"},{"key":"key2.0220127073431e+13_ref16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/19396368.2015.1033779","article-title":"Effects of high progesterone on outcomes of in\n                            vitro fertilization-embryo transfer in patients with different\n                        ovarian responses","volume":"61","author":"Li","year":"2015","journal-title":"Syst Biol Reprod Med"},{"key":"key2.0220127073431e+13_ref17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13048-020-0615-0","article-title":"Decreased ovarian function and autophagy gene methylation in\n                        aging rats","volume":"13","author":"Li","year":"2020","journal-title":"J Ovarian Res"},{"key":"key2.0220127073431e+13_ref18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1210\/er.2005-0015","article-title":"The science behind 25 years of ovarian stimulation for in\n                            vitro fertilization","volume":"27","author":"Macklon","year":"2006","journal-title":"Endocr Rev"},{"key":"key2.0220127073431e+13_ref19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2169\/internalmedicine.37.179","article-title":"Fas-induced apoptosis","volume":"37","author":"Nagata","year":"1998","journal-title":"Intern Med"},{"key":"key2.0220127073431e+13_ref20","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1159\/000495895","article-title":"Establishment of a mouse model of premature ovarian failure using\n                        consecutive superovulation","volume":"51","author":"Nie","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"key2.0220127073431e+13_ref21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/REP-09-0187","article-title":"The impact of ovarian stimulation for IVF on the developing\n                        embryo","volume":"139","author":"Santos","year":"2010","journal-title":"Reproduction"},{"key":"key2.0220127073431e+13_ref22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1254\/jphs.92.19","article-title":"Prostaglandin F2\u03b1-induced functional regression\n                        of the corpus luteum and apoptosis in rodents","volume":"92","author":"Wang","year":"2003","journal-title":"J Pharmacol Sci"},{"key":"key2.0220127073431e+13_ref23","doi-asserted-by":"crossref","first-page":"8732023","DOI":"10.1155\/2019\/8732023","article-title":"Dynamic changes of DNA methylation and transcriptome expression\n                        in porcine ovaries during aging","volume":"2019","author":"Xi","year":"2019","journal-title":"BioMed Res Int"},{"key":"key2.0220127073431e+13_ref24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10815-017-0872-z","article-title":"Long-term effects of repeated superovulation on the uterus and\n                        mammary gland in rhesus monkeys","volume":"34","author":"Yan","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"key2.0220127073431e+13_ref25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.cr.7290234","article-title":"Apoptosis in granulosa cells during follicular atresia:\n                        Relationship with steroids and insulin-like growth factors","volume":"14","author":"Yu","year":"2004","journal-title":"Cell Res"},{"key":"key2.0220127073431e+13_ref26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13578-020-00396-1","article-title":"mTOR signaling pathway and mTOR inhibitors in cancer: Progress\n                        and challenges","volume":"10","author":"Zou","year":"2020","journal-title":"Cell Biosci"}],"container-title":["Development & Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2021.25.4.213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2021.25.4.213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T06:35:27Z","timestamp":1643265327000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ksdb.org\/archive\/view_article?doi=10.12717\/DR.2021.25.4.213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,31]]},"published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.12717\/DR.2021.25.4.213"],"URL":"https:\/\/doi.org\/10.12717\/dr.2021.25.4.213","relation":{},"ISSN":["2465-9525","2465-9541"],"issn-type":[{"value":"2465-9525","type":"print"},{"value":"2465-9541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}