{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T19:57:28Z","timestamp":1768939048082,"version":"3.49.0"},"reference-count":34,"publisher":"Korean Society of Developmental Biology","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creative-commons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1C1C1011346"],"award-info":[{"award-number":["2021R1C1C1011346"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00443714"],"award-info":[{"award-number":["RS-2024-00443714"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ksdb.org"],"crossmark-restriction":true},"short-container-title":["Dev. Reprod."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.12717\/dr.2025.29.4.137","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:28:26Z","timestamp":1768886906000},"page":"137-149","update-policy":"https:\/\/doi.org\/10.12717\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nitrogen-Doped Carbon Quantum Dots Enhance In Vitro Fertilization and Early Embryo Development by Improving Sperm Activation in Mice"],"prefix":"10.12717","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0780-3107","authenticated-orcid":false,"given":"Hyunhee","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-0704","authenticated-orcid":false,"given":"Jae-Wan","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-6854","authenticated-orcid":false,"given":"Hoon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5022","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"key2.0260120062818e+13_ref1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/ars.2010.3186","article-title":"Redox regulation of human sperm function: From the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line","volume":"14","author":"Aitken","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"key2.0260120062818e+13_ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/biology9090269","article-title":"Oxidative stress in reproduction: A mitochondrial perspective","volume":"9","author":"Almansa-Ordonez","year":"2020","journal-title":"Biology"},{"key":"key2.0260120062818e+13_ref3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/antiox10020220","article-title":"Antioxidant-based therapies in male infertility: Do we have sufficient evidence supporting their effectiveness?","volume":"10","author":"Amorini","year":"2021","journal-title":"Antioxidants"},{"key":"key2.0260120062818e+13_ref4","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1113\/JP281994","article-title":"Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss","volume":"599","author":"Capatina","year":"2021","journal-title":"J Physiol"},{"key":"key2.0260120062818e+13_ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s43043-022-00094-7","article-title":"Understanding sperm motility mechanisms and the implication of sperm surface molecules in promoting motility","volume":"27","author":"Chakraborty","year":"2022","journal-title":"Middle East Fertil Soc J"},{"key":"key2.0260120062818e+13_ref6","doi-asserted-by":"crossref","first-page":"767161","DOI":"10.3389\/fcell.2021.767161","article-title":"Capacitation-induced mitochondrial activity is required for sperm fertilizing ability in mice by modulating hyperactivation","volume":"9","author":"Giaccagli","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"key2.0260120062818e+13_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.abe4375","article-title":"A balanced Oct4 interactome is crucial for maintaining pluripotency","volume":"8","author":"Han","year":"2022","journal-title":"Sci Adv"},{"key":"key2.0260120062818e+13_ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1262\/jrd.2013-136","article-title":"Microdroplet in vitro fertilization can reduce the number of spermatozoa necessary for fertilizing oocytes","volume":"60","author":"Hasegawa","year":"2014","journal-title":"J Reprod Dev"},{"key":"key2.0260120062818e+13_ref9","doi-asserted-by":"crossref","first-page":"17156","DOI":"10.1038\/s41598-017-16009-w","article-title":"The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation","volume":"7","author":"Huang","year":"2017","journal-title":"Sci Rep"},{"key":"key2.0260120062818e+13_ref10","doi-asserted-by":"crossref","first-page":"022404","DOI":"10.1063\/1.4915612","article-title":"Embryo formation from low sperm concentration by using dielectrophoretic force","volume":"9","author":"Huang","year":"2015","journal-title":"Biomicrofluidics"},{"key":"key2.0260120062818e+13_ref11","doi-asserted-by":"crossref","first-page":"19326","DOI":"10.1038\/s41598-021-98918-5","article-title":"Effects of artificial cycles with and without gonadotropin-releasing hormone agonist pretreatment on frozen embryo transfer outcomes in patients with adenomyosis","volume":"11","author":"Li","year":"2021","journal-title":"Sci Rep"},{"key":"key2.0260120062818e+13_ref12","doi-asserted-by":"crossref","first-page":"110784","DOI":"10.1016\/j.dyepig.2022.110784","article-title":"Carbon quantum dots as ROS-generator and -scavenger: A comprehensive review","volume":"208","author":"Li","year":"2023","journal-title":"Dyes Pigments"},{"key":"key2.0260120062818e+13_ref13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/ijms20020409","article-title":"Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in mammalian oocyte maturation and preimplantation embryo development","volume":"20","author":"Lin","year":"2019","journal-title":"Int J Mol Sci"},{"key":"key2.0260120062818e+13_ref14","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/s20041072","article-title":"Applications of graphene quantum dots in biomedical sensors","volume":"20","author":"Mansuriya","year":"2020","journal-title":"Sensors"},{"key":"key2.0260120062818e+13_ref15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1530\/rep.0.1240065","article-title":"Alleviation of the two-cell block of ICR mouse embryos by polyaminocarboxylate metal chelators","volume":"124","author":"Matsukawa","year":"2002","journal-title":"Reproduction"},{"key":"key2.0260120062818e+13_ref16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4103\/1008-682X.154312","article-title":"The future of computer-aided sperm analysis","volume":"17","author":"Mortimer","year":"2015","journal-title":"Asian J Androl"},{"key":"key2.0260120062818e+13_ref17","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2005.08.040","article-title":"Interaction between Oct3\/4 and Cdx2 determines trophectoderm differentiation","volume":"123","author":"Niwa","year":"2005","journal-title":"Cell"},{"key":"key2.0260120062818e+13_ref18","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmeth.1248","article-title":"Quantum dots versus organic dyes as fluorescent labels","volume":"5","author":"Resch-Genger","year":"2008","journal-title":"Nat Methods"},{"key":"key2.0260120062818e+13_ref19","doi-asserted-by":"crossref","first-page":"100407","DOI":"10.1016\/j.cartre.2024.100407","article-title":"Biomedical application of carbon quantum dots: A review","volume":"17","author":"Salvi","year":"2024","journal-title":"Carbon Trends"},{"key":"key2.0260120062818e+13_ref20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response","volume":"74","author":"Schr\u00f6der","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"key2.0260120062818e+13_ref21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/19768354.2024.2409452","article-title":"Nitrogen-doped carbon quantum dot regulates cell proliferation and differentiation by endoplasmic reticulum stress","volume":"28","author":"Song","year":"2024","journal-title":"Anim Cells Syst"},{"key":"key2.0260120062818e+13_ref22","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1242\/dev.01801","article-title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","volume":"132","author":"Strumpf","year":"2005","journal-title":"Development"},{"key":"key2.0260120062818e+13_ref23","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3390\/biom15091215","article-title":"The role of preconception parental health on embryo quality\u2014preliminary results of a prospective study using non-Invasive preimplantation genetic testing for aneuploidy","volume":"15","author":"Tomic","year":"2025","journal-title":"Biomolecules"},{"key":"key2.0260120062818e+13_ref24","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/ar300040z","article-title":"Are quantum dots toxic? Exploring the discrepancy between cell culture and animal studies","volume":"46","author":"Tsoi","year":"2013","journal-title":"Acc Chem Res"},{"key":"key2.0260120062818e+13_ref25","doi-asserted-by":"crossref","first-page":"e10622","DOI":"10.1371\/journal.pone.0010622","article-title":"Brg1 is required for Cdx2-mediated repression of Oct4 expression in mouse blastocysts","volume":"5","author":"Wang","year":"2010","journal-title":"PLOS ONE"},{"key":"key2.0260120062818e+13_ref26","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.2147\/IJN.S360000","article-title":"Beneficial effect of selenium doped carbon quantum dots supplementation on the in vitro development competence of ovine oocytes","volume":"17","author":"Wang","year":"2022","journal-title":"Int J Nanomed"},{"key":"key2.0260120062818e+13_ref27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.scitotenv.2017.12.334","article-title":"Review of in vitro toxicological research of quantum dot and potentially involved mechanisms","volume":"625","author":"Wang","year":"2018","journal-title":"Sci Total Environ"},{"key":"key2.0260120062818e+13_ref28","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1038\/s41598-017-15427-0","article-title":"Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF\/MAPK pathway","volume":"7","author":"Wigger","year":"2017","journal-title":"Sci Rep"},{"key":"key2.0260120062818e+13_ref29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2045-9769-3-7","article-title":"Role of Oct4 in the early embryo development","volume":"3","author":"Wu","year":"2014","journal-title":"Cell Regen"},{"key":"key2.0260120062818e+13_ref30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ecoenv.2016.07.026","article-title":"Carbon and metal quantum dots toxicity on the microalgae Chlorella pyrenoidosa","volume":"133","author":"Xiao","year":"2016","journal-title":"Ecotoxicol Environ Saf"},{"key":"key2.0260120062818e+13_ref31","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1071\/RD17475","article-title":"Evaluation of sperm motility with CASA-Mot: Which factors may influence our measurements?","volume":"30","author":"Yeste","year":"2018","journal-title":"Reprod Fertil Dev"},{"key":"key2.0260120062818e+13_ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.biomaterials.2018.12.001","article-title":"Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health","volume":"194","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"key2.0260120062818e+13_ref33","doi-asserted-by":"crossref","first-page":"121397","DOI":"10.1016\/j.envpol.2023.121397","article-title":"MPA-capped CdTequantum dots induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human liver normal cell and liver tumor cell","volume":"326","author":"Zhang","year":"2023","journal-title":"Environ Pollut"},{"key":"key2.0260120062818e+13_ref34","doi-asserted-by":"crossref","first-page":"117361","DOI":"10.1016\/j.ecoenv.2024.117361","article-title":"Carbon dots induce endoplasmic reticulum stress-mediated lipid dysregulation and embryonic developmental toxicity in zebrafish","volume":"288","author":"Zhong","year":"2024","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Development &amp; Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2025.29.4.137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.ksdb.org\/download\/download_pdf?doi=10.12717\/DR.2025.29.4.137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:28:43Z","timestamp":1768886923000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ksdb.org\/archive\/view_article?doi=10.12717\/DR.2025.29.4.137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,31]]},"published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.12717\/DR.2025.29.4.137"],"URL":"https:\/\/doi.org\/10.12717\/dr.2025.29.4.137","relation":{},"ISSN":["2465-9525","2465-9541"],"issn-type":[{"value":"2465-9525","type":"print"},{"value":"2465-9541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}