{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:53:50Z","timestamp":1790420030805,"version":"4.1.0"},"reference-count":35,"publisher":"Medical Association of Nippon Medical School","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nippon Med Sch"],"published-print":{"date-parts":[[2000]]},"DOI":"10.1272\/jnms.67.177","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T17:34:57Z","timestamp":1030383297000},"page":"177-185","source":"Crossref","is-referenced-by-count":55,"title":["Overexpression and Localization of Heat Shock Proteins mRNA in Pancreatic Carcinoma"],"prefix":"10.1272","volume":"67","author":[{"given":"Masao","family":"Ogata","sequence":"first","affiliation":[{"name":"Department of Pathology, Second Department of Surgery,The Center for Digestive Diseases, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenya","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Pathology, Second Department of Surgery,The Center for Digestive Diseases, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Second Department of Surgery,The Center for Digestive Diseases, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhkichi","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Second Department of Surgery,The Center for Digestive Diseases, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Second Department of Surgery,The Center for Digestive Diseases, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"21","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Lindquist S, Craig EA: The heat-shock proteins. Annu Rev Genet, 1988; 22: 631-677.","DOI":"10.1146\/annurev.ge.22.120188.003215"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Xu Y, Lidquist S: Heat-shock protein hsp90 governs the activity of pp60v-src kinase. Proc Natl Acad Sci USA 1993; 90: 7074-7078.","DOI":"10.1073\/pnas.90.15.7074"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Schuh S, Yonemoto W, Brugge J, Riehl RM, Sullivian WP, Toft DO: A 90, 000-Dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src. J Biol Chem 1985; 260: 14292-14296.","DOI":"10.1016\/S0021-9258(17)38716-1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lees-Miller SP, Anderson CW: Two human 90-kDa heat shock proteins are phospholylated in vivo at conserved serines that are phospholylated in vitro by casein kinase II. J Biol Chem 1989; 264: 2431-2437.","DOI":"10.1016\/S0021-9258(19)81631-9"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Rose DW, Welch WJ, Kramer G, Hardesty B: Possible involvement of the 90-kDa heat shock protein in the regulation of protein synthesis. J Biol Chem 1989; 264: 6239-6244.","DOI":"10.1016\/S0021-9258(18)83339-7"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Koyasu S, Nishida E, Kadowaki T, Matsuzaki F, Iida K, Harada F, Kasuga M, Sakai H, Yahara I: Two mammalian heat shock proteins, hsp90 and hsp100, are actin-binding proteins. Proc Natl Acad Sci USA 1986; 83: 8054-8058.","DOI":"10.1073\/pnas.83.21.8054"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Schlesinger MJ: Heat shock proteins. J Biol Chem 1990; 265: 12111-12114.","DOI":"10.1016\/S0021-9258(19)38314-0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Catelli MG, Jung-Testas I, Renoir JM, Baulieu EE, Feramisco JR, Welch WJ: The common 90-kd protein component of non-transformed '8S' steroid receptors is a heat-shock protein. ENBO J 1985; 4: 3131-3137.","DOI":"10.1002\/j.1460-2075.1985.tb04055.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Jerome V, Vourc'h C, Baulien EE, Catelli MG: Cell cycle regulation of the chicken hsp90&alpha; expression. Exp Cell Res 1993; 205: 44-51.","DOI":"10.1006\/excr.1993.1056"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Aligue R, Akhavan-Niak H, Russel P: A role for hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with hsp90. EMBO J 1994; 13: 6099-6106.","DOI":"10.1002\/j.1460-2075.1994.tb06956.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Jameel A, Skilton RA, Campbell SK, Coombes RC, Luqmani YA: Clinical andbiological significance of hsp89 alpha in human breast cancer. Int J Cancer 1992; 50: 409-415.","DOI":"10.1002\/ijc.2910500315"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yuhu Y, Nishimura J, Nawata H: High constitutive expression of heat shock protein 90&alpha; in human acute leukemia cells. Leuk Res 1992; 16: 597-605.","DOI":"10.1016\/0145-2126(92)90008-U"},{"key":"13","unstructured":"13) Gress MT, Muller-Pillasch F, Weber C, Lerch MM, Friess H, Buchler M, Beger HG, Adler G: Differential expression of heat shock proteins in pancreatic carcinoma. Cancer Res 1994; 54: 547-551."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hainaut P, Milner J: Interaction of heat shock protein 70 with p53 translated in vitro: Evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation. EMBO J 1992; 11: 3513-3520.","DOI":"10.1002\/j.1460-2075.1992.tb05434.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Milarski KL, Morimoto RI: Expression of human hsp70 during the synthetic phase of the cell cycle. Proc Natl Acad Sci USA 1986; 83: 9517-9521.","DOI":"10.1073\/pnas.83.24.9517"},{"key":"16","unstructured":"16) Morimoto H, Monden T, Miyoshi Y, Kawasaki Y, Nakanishi H, Shimano T, Mori T: Expression of p53 and heat shock protein in colorectal tumors: An immunohistochemical study. J Jpn Sur Soci 1991; 9: 1094-1097."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ciocca DR, Clark GM, Tandon AK, Fuqua SAW, Welch WJ, McGuire WL: Heat shock protein hsp70 in patients with axillary lymphnode-negative breast cancer: Prognostic implications. J Natl Cancer Inst 1993; 85: 570-574.","DOI":"10.1093\/jnci\/85.7.570"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hikkei E, Brandon SE, Smale G, LLoyd D, Weber LA: Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. Mol Cell Biol 1989; 9: 2615-2625.","DOI":"10.1128\/MCB.9.6.2615"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19) Rebbe NF, Ware J, Bertina RM, Modrich D, Stafford DW: Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family. Gene 1897; 53: 235-245.","DOI":"10.1016\/0378-1119(87)90012-6"},{"key":"20","unstructured":"20) Ishiwata T, Asano G: Examination of extracellular matrices messenger RNA using in situ hybridization method. Connective Tissue 1995; 26: 355-360."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kinoshita T, Imamura J, Nagai H, Shimotohno K: Quantification gene expression over a wide range by the polymerase chain reaction. Anal Biochem 1992; 206: 231-235.","DOI":"10.1016\/0003-2697(92)90358-E"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Rosen JB, Pishevar SK, Weiss SRB, Smith MA, Kling MA, Gold PW, Schulkin J: Glucocorticoid treatment increases the ability of CRH to induce seizures. Neurosci Lett 1994; 174: 113-116.","DOI":"10.1016\/0304-3940(94)90132-5"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23) Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992; 358: 80-83.","DOI":"10.1038\/358080a0"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24) Momand J, Zambetti GP, Olsen DC, George D, Levine AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-1245.","DOI":"10.1016\/0092-8674(92)90644-R"},{"key":"25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","volume":"75","year":"1993","unstructured":"25) El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B: WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-825.","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(93)90499-G","volume":"75","year":"1993","unstructured":"26) Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805-816.","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27) Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D: P21 is a universal inhibitor of cyclin kinases. Nature 1993; 366: 701-704.","DOI":"10.1038\/366701a0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR: Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211: 90-98.","DOI":"10.1006\/excr.1994.1063"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29) Li R, Waga S, Hannon GJ, Beach D, Stillman B: Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 1994; 371: 534-537.","DOI":"10.1038\/371534a0"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Moore SK, Kozac C, Robinson EA, Ullrich SJ, Appella E: Murine 86-and 84-kDa heat shock proteins, cDNA sequence, chromosome assignment and evolutionary origin. J Biol Chem 1989; 264: 5343-5351.","DOI":"10.1016\/S0021-9258(18)83551-7"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Vamvakopoulos NC, Griffin CA, Hawkins AL, Lee C, Chrousos GP, Jabs EW: Mapping the intron-containing human hsp90&alpha; (HSPCAL4) gene to chromosome band 14q32. Cytogenet Cell Genet 1993; 64: 224-226.","DOI":"10.1159\/000133582"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Takahashi T, Tamura R, Hirata M, Hashimoto K: A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein &beta; gene (hsp90&beta; ). Mamm Genome 1994; 5: 121-122.","DOI":"10.1007\/BF00292342"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Minami Y, Kawasaki H, Miyata Y, Suzuki K, Yahara I: Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, hsp90. J Biol Chem 1991; 266: 10099-10103.","DOI":"10.1016\/S0021-9258(18)99195-7"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Jameel A, Law M, Coombes RC, Luqmani YA: Significance of heat shock protein 90 as a prognostic indicator in breast cancer. Int J Oncol 1993; 2: 1075-1080.","DOI":"10.3892\/ijo.2.6.1075"},{"key":"35","unstructured":"35) Yamada T, Nakamura R, Kido K, Hata J: Function of hsp90 in differentiation and apoptosis human EC cells. Trans Soc Pathol Jpn 1995; 84: 217."}],"container-title":["Journal of Nippon Medical School"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/67\/3\/67_3_177\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T05:51:08Z","timestamp":1622094668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/67\/3\/67_3_177\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1272\/jnms.67.177","relation":{},"ISSN":["1345-4676","1347-3409"],"issn-type":[{"value":"1345-4676","type":"print"},{"value":"1347-3409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}