{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:35:04Z","timestamp":1788042904830,"version":"build-2784847793"},"reference-count":44,"publisher":"Medical Association of Nippon Medical School","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nippon Med Sch"],"published-print":{"date-parts":[[2012]]},"DOI":"10.1272\/jnms.79.129","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T06:45:05Z","timestamp":1337841905000},"page":"129-138","source":"Crossref","is-referenced-by-count":15,"title":["Involvement of Tachykinins and NK&lt;sub&gt;1&lt;\/sub&gt; Receptor in the Joint Inflammation with Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice"],"prefix":"10.1272","volume":"79","author":[{"given":"Akira","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Restorative Medicine of Neuro-musculoskeletal System, Orthopaedic Surgery, Graduate School of Medicine, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Graduate School of Medicine, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromoto","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Restorative Medicine of Neuro-musculoskeletal System, Orthopaedic Surgery, Graduate School of Medicine, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neuropharmacology, Graduate School of Medicine, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"21","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bolon B, Stolina M, King C, et al.: Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy. J Biomed Biotechnol 2011; 2011: 569068.","DOI":"10.1155\/2011\/569068"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. McDougall JJ: Arthritis and pain: neurogenic origin of joint pain. Arthritis Res Ther 2006; 8: 220.","DOI":"10.1186\/ar2069"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Todd AJ: Neuronal circuitry for pain processing in the dorsal horn. Nat Rev Neurosci 2010; 11: 823-836.","DOI":"10.1038\/nrn2947"},{"key":"4","unstructured":"8. Zhang Y, Berger A, Milne CD, Paige CJ: Tachykinins in the immune system. Curr Drug Targets 2006; 7: 1011-1020."},{"key":"5","unstructured":"9. Tuluc F, Lai JP, Kilpatrick LE, Evans DL, Douglas SD: Neurokinin 1 receptor isoforms and the control of innate immunity. Trends Immunol 2009; 30: 272-276."},{"key":"6","doi-asserted-by":"crossref","unstructured":"11. Hong SK, Han JS, Min SS, et al.: Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat. Neurosci Lett 2002; 322: 21-24.","DOI":"10.1016\/S0304-3940(02)00070-8"},{"key":"7","doi-asserted-by":"crossref","unstructured":"12. Denadai-Souza A, Camargo Lde L, Ribela MT, Keeble JE, Costa SK, Muscar&aacute; MN: Participation of peripheral tachykinin NK<sub>1<\/sub> receptors in the carrageenan-induced inflammation of the rat temporomandibular joint. Eur J Pain 2009; 13: 812-819.","DOI":"10.1016\/j.ejpain.2008.09.012"},{"key":"8","doi-asserted-by":"crossref","unstructured":"15. Devillier P, Weill B, Renoux M, Menk&egrave;s C, Pradelles P: Elevated levels of tachykinin-like immunoreactivity in joint fluids from patients with rheumatic inflammatory diseases. N Engl J Med 1986; 314: 1323.","DOI":"10.1056\/NEJM198605153142018"},{"key":"9","unstructured":"16. Matucci-Cerinic M, Lombardi A, Leoncini G, et al.: Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation? Rheumatol Int 1993; 13: 1-4."},{"key":"10","unstructured":"17. Anichini M, Cesaretti S, Lepori M, Maddali Bongi S, Maresca M, Zoppi M: Substance P in the serum of patients with rheumatoid arthritis. Rev Rhum Engl Ed 1997; 64: 18-21."},{"key":"11","doi-asserted-by":"crossref","unstructured":"18. Grimsholm O, Rantap&auml;&auml;-Dahlqvist S, Forsgren S: Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis. Arthritis Res Ther 2005; 7: R416-R426.","DOI":"10.1186\/ar1503"},{"key":"12","doi-asserted-by":"crossref","unstructured":"20. Page NM: Hemokinins and endokinins. Cell Mol Life Sci 2004; 61: 1652-1663.","DOI":"10.1007\/s00018-004-4035-x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"21. Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ: Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat Immunol 2000; 1: 392-397.","DOI":"10.1038\/80826"},{"key":"14","doi-asserted-by":"crossref","unstructured":"22. Duffy RA, Hedrick JA, Randolph G, et al.: Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils. Neuropharmacology 2003; 45: 242-250.","DOI":"10.1016\/S0028-3908(03)00150-3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"23. Nelson DA, Marriott I, Bost KL: Expression of hemokinin 1 mRNA by murine dendritic cells. J Neuroimmunol 2004; 155: 94-102.","DOI":"10.1016\/j.jneuroim.2004.06.005"},{"key":"16","doi-asserted-by":"crossref","unstructured":"24. Metwali A, Blum AM, Elliott DE, Setiawan T, Weinstock JV: Cutting edge: hemokinin has substance P-like function and expression in inflammation. J Immunol 2004; 172: 6528-6532.","DOI":"10.4049\/jimmunol.172.11.6528"},{"key":"17","doi-asserted-by":"crossref","unstructured":"26. Wang W, Li Q, Zhang J, et al.: Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production. J Immunol 2010; 184: 3590-3597.","DOI":"10.4049\/jimmunol.0901278"},{"key":"18","doi-asserted-by":"crossref","unstructured":"27. Liu L, Markus I, Saghire HE, Perera DS, King DW, Burcher E: Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1? Neurogastroenterol Motil 2011; 23: 475-e180.","DOI":"10.1111\/j.1365-2982.2011.01685.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"28. Endo D, Ikeda T, Ishida Y, Yoshioka D, Nishimori T: Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw. Neurosci Lett 2006; 392: 114-117.","DOI":"10.1016\/j.neulet.2005.09.005"},{"key":"20","doi-asserted-by":"crossref","unstructured":"29. Watanabe C, Mizoguchi H, Yonezawa A, Sakurada S: Characterization of intrathecally administered hemokinin-1-induced nociceptive behaviors in mice. Peptides 2010; 31: 1613-1616.","DOI":"10.1016\/j.peptides.2010.04.025"},{"key":"21","doi-asserted-by":"crossref","unstructured":"30. Matsumura T, Sakai A, Nagano M, et al.: Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state. Br J Pharmacol 2008; 155: 767-774.","DOI":"10.1038\/bjp.2008.301"},{"key":"22","doi-asserted-by":"crossref","unstructured":"31. Nandakumar KS, Svensson L, Holmdahl R: Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol 2003; 163: 1827-1837.","DOI":"10.1016\/S0002-9440(10)63542-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"33. Kagari T, Doi H, Shimozato T: The importance of IL-1&beta; and TNF-&alpha;, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 2002; 169: 1459-1466.","DOI":"10.4049\/jimmunol.169.3.1459"},{"key":"24","doi-asserted-by":"crossref","unstructured":"34. Kagari T, Tanaka D, Doi H, Shimozato T: Essential role of Fc&gamma; receptors in anti-type II collagen antibody-induced arthritis. J Immunol 2003; 170: 4318-4324.","DOI":"10.4049\/jimmunol.170.8.4318"},{"key":"25","doi-asserted-by":"crossref","unstructured":"36. Banda NK, Takahashi K, Wood AK, Holers VM, Arend WP: Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway. J Immunol 2007; 179: 4101-4109.","DOI":"10.4049\/jimmunol.179.6.4101"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400199200"},{"key":"28","doi-asserted-by":"crossref","unstructured":"39. Bley KR, Hunter JC, Eglen RM, Smith JAM: The role of IP prostanoid receptors in inflammatory pain. Trends Pharmacol Sci 1998; 19: 141-147.","DOI":"10.1016\/S0165-6147(98)01185-7"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215528"},{"key":"30","doi-asserted-by":"crossref","unstructured":"41. Nagano M, Saitow F, Haneda E, Konishi S, Hayashi M, Suzuki H: Distribution and pharmacological characterization of primate NK-1 and NK-3 tachykinin receptors in the central nervous system of the rhesus monkey. Br J Pharmacol 2006; 147: 316-323.","DOI":"10.1038\/sj.bjp.0706561"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90202-X"},{"key":"32","doi-asserted-by":"crossref","unstructured":"43. Walker JS, Scott C, Bush KA, Kirkham BW: Effects of the peripherally selective &kappa;-opioid asimadoline, on substance P and CGRP mRNA expression in chronic arthritis of the rat. Neuropeptides 2000; 34: 193-202.","DOI":"10.1054\/npep.2000.0813"},{"key":"33","doi-asserted-by":"crossref","unstructured":"44. Donaldson LF, Harmar AJ, McQueen DS, Seckl JR: Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat. Mol Res Mol Brain Res 1992; 16: 143-149.","DOI":"10.1016\/0169-328X(92)90204-O"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00272-8"},{"key":"35","doi-asserted-by":"crossref","unstructured":"47. Basbaum AI: Spinal mechanisms of acute and persistent pain. Reg Anesth Pain Med 1999; 24: 59-67.","DOI":"10.1097\/00115550-199924010-00012"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2000.0171"},{"key":"37","doi-asserted-by":"crossref","unstructured":"49. O'Shaughnessy MC, Vetsika EK, Inglis JJ, et al.: The effect of substance P on nitric oxide release in a rheumatoid arthritis model. Inflamm Res 2006; 55: 236-240.","DOI":"10.1007\/s00011-006-0079-8"},{"key":"38","doi-asserted-by":"crossref","unstructured":"50. Binder W, Scott C, Walker JS: Involvement of substance P in the anti-inflammatory effects of the peripherally selective &kappa;-opioid asimadoline and the NK<sub>1<\/sub> antagonist GR205171. Eur J Neurosci 1999; 11: 2065-2072.","DOI":"10.1046\/j.1460-9568.1999.00625.x"},{"key":"39","doi-asserted-by":"crossref","unstructured":"51. Goronzy JJ, Weyand CM: Rheumatoid arthritis. Immunol Rev 2005; 204: 55-73.","DOI":"10.1111\/j.0105-2896.2005.00245.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"52. Bartok B, Firestein GS: Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-255.","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"53. Miyazawa S, Nishida K, Komiyama T, et al.: Novel transdermal photodynamic therapy using ATX-S10&middot;Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice. Rheumatol Int 2006; 26: 717-725.","DOI":"10.1007\/s00296-005-0052-9"},{"key":"42","unstructured":"55. Menkes CJ, Renoux M, Laoussadi S, Mauborgne A, Bruxelle J, Cesselin F: Substance P levels in the synovium and synovial fluid from patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 1993; 20: 714-717."},{"key":"43","doi-asserted-by":"crossref","unstructured":"56. Berger A, Tran AH, Paige CJ: Co-regulated decrease of neurokinin-1 receptor and hemokinin-1 gene expression in monocytes and macrophages after activation with pro-inflammatory cytokines. J Neuroimmunol 2007; 187: 83-93.","DOI":"10.1016\/j.jneuroim.2007.04.019"},{"key":"44","unstructured":"57. Klassert TE, Pinto F, Hern&aacute;ndez M, et al.: Differential expression of neurokinin B and hemokinin-1 in human immune cells. J Immunol 2008; 196: 27-34."}],"container-title":["Journal of Nippon Medical School"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/79\/2\/79_129\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T22:42:29Z","timestamp":1687473749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/79\/2\/79_129\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1272\/jnms.79.129","relation":{},"ISSN":["1345-4676","1347-3409"],"issn-type":[{"value":"1345-4676","type":"print"},{"value":"1347-3409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}