{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:11:24Z","timestamp":1770678684696,"version":"3.49.0"},"reference-count":56,"publisher":"Medical Association of Nippon Medical School","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nippon Med Sch"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1272\/jnms.80.104","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T03:12:32Z","timestamp":1367982752000},"page":"104-109","source":"Crossref","is-referenced-by-count":11,"title":["Sleep Disorders in Functional Dyspepsia and Future Therapy"],"prefix":"10.1272","volume":"80","author":[{"given":"Seiji","family":"Futagami","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Shimpuku","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kodaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagoya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiga","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Shindo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kawagoe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"21","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Doi Y, Minowa M, Okawa M, Uchiyama M: Prevalence of sleep disturbance and hypnotic medication use in relation to sociodemographic factors in the general Japanese adult population. J Epidermiol 2000; 10: 79-86.","DOI":"10.2188\/jea.10.79"},{"key":"2","unstructured":"2. Kim K, Uchiyama M, Okawa M, Liu X, Ogihara R: An epidemiological study of insomnia among the Japanese general population. Sleep 2000; 23: 41-47."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kim K, Uchiyama M, Liu X, et al.: Somatic and psychological complains and their correlates with insomnia in the Japanese general population. Psychosom Med 2001; 63: 441-446.","DOI":"10.1097\/00006842-200105000-00013"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Weissman MM, Greenwald S, Nino-Murcia G, Dement WC: The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry 1997; 19: 245-250.","DOI":"10.1016\/S0163-8343(97)00056-X"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Parish J: Sleep-related problems in common medical conditions. Chest 2009; 135: 563-572.","DOI":"10.1378\/chest.08-0934"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fass R, Fullerton S, Tung S, Mayer EA: Sleep disturbances in clinic patients with functional bowel disorders. Am J Gastroenterol 2000; 95: 1195-2000.","DOI":"10.1111\/j.1572-0241.2000.02009.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Jarrett M, Heitkemper M, Cain KC, Burr RL, Hertig V: Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. Dig Dis Sci 2000; 45: 952-959.","DOI":"10.1023\/A:1005581226265"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Goldsmith G, Levin JS: Effect of sleep quality on symptoms of irritable bowel syndrome. Dig Dis Sci 1993; 38: 1809-1814.","DOI":"10.1007\/BF01296103"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group: The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006; 101: 1900-1920.","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Vege SS, Locke GR 3rd, Weaver AL, Farmer SA, Melton LJ 3rd, Talley NJ: Functional gastrointestinal disorders among people with sleep disturbances: a population-based study. Mayo Clin Proc 2004; 79: 1501-1506.","DOI":"10.4065\/79.12.1501"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Lacy BE, Everhart K, Crowell MD: Functional dyspepsia is associated with sleep disorders. Clin Gastroenterol Hepatol 2011; 9: 410-414.","DOI":"10.1016\/j.cgh.2011.02.010"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Tack J, Talley NJ, Camilleri M, et al.: Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466-1479.","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ 3rd: Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 1992; 102 (Pt 1): 1259-1268.","DOI":"10.1016\/0016-5085(92)70021-3"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Castillo EJ, Camilleri M, Locke GR, et al.: A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia. Clin Gastroenterol Hepatol 2004; 2: 985-996.","DOI":"10.1016\/S1542-3565(04)00454-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J: Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346-1352.","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Lunding JA, Tefera S, Gilja OH, et al.: Rapid initial gastric emptying and hypersensitivity to gastric filling in functional dyspepsia:effects of duodenal lipids. Scand J Gastroenterol 2006; 41: 1028-1036.","DOI":"10.1080\/00365520600590513"},{"key":"17","unstructured":"17. Holtmann G, Goebell H, Talley J: Impaired small intestinal peristaltic refluxes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia. Am J Gastroenterol 1996; 91: 485-491."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Samsom M, Verhagen MA, vanBerge Henegouwen GP, Smout AJ: Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology 1999; 116: 515-520.","DOI":"10.1016\/S0016-5085(99)70171-X"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Takahashi Y, Amano Y, Yuki T, et al.: Influence of acid suppressants on gastric emptying: cross-over analysis in healthy volunteers. J Gastroenterol Hepatol 2006; 21: 1664-1668.","DOI":"10.1111\/j.1440-1746.2006.04270.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Shimpuku M, Futagami S, Kawagoe T, et al.: G-protein β3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese. Neurogastroenterol Motil 2011; 23: 1073-1080.","DOI":"10.1111\/j.1365-2982.2011.01781.x"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Holtmann G, Siffert W, Haag S, et al.: G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 2004; 126: 971-979.","DOI":"10.1053\/j.gastro.2004.01.006"},{"key":"22","unstructured":"22. Quigley EM: Gastric motor and sensory function, and motor disorders of the stomach. In Gastrointestinal and liver disease, pathophysiology\/diagnosis\/management (Feldman M, Friedman LS, Sleisenger MH, eds), 2002; pp 691-714, WB Sanders, Philadelphia."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Futagami S, Shindo T, Kawagoe T, et al.: Migration of eosinophils and CCR2-\/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am J Gastroenterol 2010; 105: 1835-1842.","DOI":"10.1038\/ajg.2010.151"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Quigley EM: Gastric emptying in functional gastrointestinal disorders. Aliment Pharmacol Ther 2004; 20 (suppl 7) : 56-60.","DOI":"10.1111\/j.1365-2036.2004.02186.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Shindo T, Futagami S, Hiratsuka T, et al.: Comparison of gastric emptying and plasma ghrelin levels in patients with functional dyspepsia and non-erosive reflux disease. Digestion 2009; 79: 65-72.","DOI":"10.1159\/000205740"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Futagami S, Iwakiri K, Shindo T, et al.: The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying. J Gastroenterol 2010; 45: 413-421.","DOI":"10.1007\/s00535-009-0173-0"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Futagami S, Shimpuku M, Song JM, et al.: Nizatidine improves clinical symptoms and gastric emptying in patients with functional dyspepsia accompanied by impaired gastric emptying. Digestion 2012; 86: 114-121.","DOI":"10.1159\/000339111"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Shaker R, Castell DO, Schoenfeld PS, Spechler SJ: Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterology 2003; 98: 1487-1493.","DOI":"10.1111\/j.1572-0241.2003.07531.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Gerson LB, Fass R: A systemic review of the definitions, prevalence, and response to treatment of nocturnal gastroesophageal reflux disease. Clin Gastroenterol Hepatol 2009; 7: 372-378.","DOI":"10.1016\/j.cgh.2008.11.021"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Yi CH, Hu CT, Chen CL: Sleep dysfunction in patients with GERD: erosive versus nonerosive reflux disease. Am J Med Sci 2007; 334: 168-170.","DOI":"10.1097\/MAJ.0b013e318141f4a5"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kusano M, Kouzu T, Kawano T, Ohara S: Nationwide epidemiological study on gastroesophageal reflux disease and sleep disorders in the Japanese population. J Gastroenterol 2008; 43: 833-841.","DOI":"10.1007\/s00535-008-2235-0"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Goldsmith G, Levin JS: Effect of sleep quality on symptoms of irritable bowel syndrome. Dig Dis Sci 1993; 38: 1809-1814.","DOI":"10.1007\/BF01296103"},{"key":"33","unstructured":"33. Doi Y, Minowa M, Okawa M, et al.: Development of the Japanese version of the Pittsburgh Sleep Quality Index. Jpn J Psychiatr Treat 1998; 13: 755-763 (in Japanese)."},{"key":"34","unstructured":"34. Futagami S, Izumi N, Shimpuku M, et al.: Impact of sleep disorders in Japanese patients with functional dyspepsia (FD): nizatidine improves clinical symptoms, gastric emptying and sleep disorders in FD patients. J Gastroenterol Hepatol in press."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Van Oudenhove L, Vandenberghe J, Geeraerts B, et al.: Relationship between anxiety and gastric sensorimotor function in functional dyspepsia. Psychosom Med 2007; 69: 455-463.","DOI":"10.1097\/PSY.0b013e3180600a4a"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Geeraerts B, Vandenberghe J, Van Oudenhove L, et al.: Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology 2005; 129: 1437-1444.","DOI":"10.1053\/j.gastro.2005.08.020"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Rhudy JL, Meagher MW: Fear and anxiety: divergent effects on human pain thresholds. Pain 2000; 84: 65-75.","DOI":"10.1016\/S0304-3959(99)00183-9"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Lorena SL, Tinois E, Brunetto SQ, Camargo EE, Mesquita MA: Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: influence of gender and anxiety. J Clin Gastroenterol 2004; 38: 230-236.","DOI":"10.1097\/00004836-200403000-00007"},{"key":"39","unstructured":"39. Monnikes H, Tebbe JJ, Hildebrandt M, et al.: Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis 2001; 19: 201-211."},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. De la Roca-Chiapas JM, Solis-Ortiz S, Fajardo-Araujo M, Sosa M, Cordova-Fraga T, Rosa-Zarate A: Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: a case-control study. J Psychosom Res 2010; 68: 73-81.","DOI":"10.1016\/j.jpsychores.2009.05.013"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Johnston BT, Lewis SA, Love AH: Stress, personality and social support in gastro-oesophageal reflux disease. J Psychosom Res 1995; 39: 221-226.","DOI":"10.1016\/0022-3999(94)00102-B"},{"key":"42","unstructured":"42. Orr WC: Gastrointestinal physiology. In Principl Pract Sleep Med, 3ed. 2000; pp 279-288."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Miwa H: Life style in persons with functional gastrointestinal disorders-large-scale internet survey of lifestyle in Japan. Neurogastroenterol Motil 2012; 24: 464-471.","DOI":"10.1111\/j.1365-2982.2011.01872.x"},{"key":"44","unstructured":"44. Talley N, Weaver AL, Zinsmeister AR: Smoking, alcohol, and nonsteroidal anti-inflammatory drugs in outpatients with functional dyspepsia. Am J Gastroenterol 1994; 89: 524-528."},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Carvalho RV, Lorena SL, Almeida JR, Mesquita MA: Food intolerance, diet composition, and eating patterns in functional dyspepsia patients. Dig Dis Sci 2010; 55: 60-65.","DOI":"10.1007\/s10620-008-0698-8"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Pilichiewicz AN, Feltrin KL, Horowitz M, et al.: Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY. Am J Gastroenterol 2008; 103: 2613-2623.","DOI":"10.1111\/j.1572-0241.2008.02041.x"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Chey WD, Moayyedi P: Uninvestigated dyspepsia and non-ulcer dyspepsia-the use of endoscopy and the roles of Helicobacter pylori eradication and antisecretory therapy. Aliment pharmacol Ther 2004; 19 suppl 1: 1-8.","DOI":"10.1111\/j.0953-0673.2004.01829.x"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Futagami S, Shimpuku M, Yin Y, et al.: Pathophysiology of Functional dyspepsia. J Nippon Med Sch 2011; 78: 280-285.","DOI":"10.1272\/jnms.78.280"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Lacy BE, Talley NJ, Locke GR 3rd, et al.: Review article: current treatment options and management of functional dyspepsia. Aliment Pharmaol Ther 2012; 36: 3-15.","DOI":"10.1111\/j.1365-2036.2012.05128.x"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Blum AL, Arnold R, Stolte M, Fischer M, Koelz HR: Short course acid suppressive treatment for patients with functional dyspepsia: results depend on Helicobacter pylori status. Gut 2000; 47: 473-480.","DOI":"10.1136\/gut.47.4.473"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Saarto T, Wiffen PJ: Antidepressants for neuropathic pain. Cochrane Detabase Syst Rev 2007; 4: CD005454.","DOI":"10.1002\/14651858.CD005454.pub2"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Ford AC, Talley N, Schoenfeld PS, Quigley EM, Moayyedi P: Efficacy of antidepressants and psychological therapies in irritable bowel syndrome: systemic review and meta-analysis. Gut 2009; 58: 367-378.","DOI":"10.1136\/gut.2008.163162"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Talley NJ, Herrick L, Locke GR: Antidepressants in functional dyspepsia. Exper Rev Gastroenterology Hepatol 2010; 4: 5-8.","DOI":"10.1586\/egh.09.73"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Talley NJ, Camilleri M, Chitkara DK, et al.: Effects of desipramine and escitalopram on postprandial symptoms induced by the nutrient drink test in healthy volunteers: a randomized, double-blind, placebo-controlled study. Digestion 2005; 72: 97-103.","DOI":"10.1159\/000088363"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Choung RS, Cremonini F, Thapa P, Zinsmeister AR, Talley NJ: The effect of short-term, low-dose tricyclic and tetracyclic antidepressant treatment on satiation, postnutrient load gastrointestinal symptoms and gastric emptying: double-blind, randomized, placebo-controlled trial. Neurogastroenterol Motil 2008; 20: 220-227.","DOI":"10.1111\/j.1365-2982.2007.01029.x"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Matsueda K, Hongo M, Tack J, et al.: Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia-100 mg t.i.d.is an optimal dosage. Neurogastroenterol Motil 2010; 22: 618-e173.","DOI":"10.1111\/j.1365-2982.2009.01449.x"}],"container-title":["Journal of Nippon Medical School"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/80\/2\/80_104\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T07:44:22Z","timestamp":1617003862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/80\/2\/80_104\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1272\/jnms.80.104","relation":{},"ISSN":["1345-4676","1347-3409"],"issn-type":[{"value":"1345-4676","type":"print"},{"value":"1347-3409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}