{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:06:32Z","timestamp":1790600792226,"version":"4.1.0"},"reference-count":27,"publisher":"Medical Association of Nippon Medical School","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nippon Med Sch"],"published-print":{"date-parts":[[2019,4,26]]},"DOI":"10.1272\/jnms.jnms.2019_86-206","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T22:09:28Z","timestamp":1558649368000},"page":"108-116","source":"Crossref","is-referenced-by-count":25,"title":["Interleukin-1beta Inhibition Attenuates Vasculitis in a Mouse Model of Kawasaki Disease"],"prefix":"10.1272","volume":"86","author":[{"given":"Yoshiaki","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Fukazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Nagi-Miura","sequence":"additional","affiliation":[{"name":"Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Ohno","sequence":"additional","affiliation":[{"name":"Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Katsube","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Kamisago","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miharu","family":"Akao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Tsuno","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nippon Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"21","reference":[{"key":"1","unstructured":"1. Murata H, Naoe S: Experimental Candida-induced arteritis in mice--relation to arteritis in Kawasaki disease. Prog Clin Biol Res 1987; 250: 523."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ohno N: Chemistry and biology of angiitis inducer, Candida albicans water-soluble mannoprotein-beta-glucan complex (CAWS). Microbiol Immunol 2003; 47: 479-490.","DOI":"10.1111\/j.1348-0421.2003.tb03409.x"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Nagi-Miura N, Harada T, Shinohara H, Kurihara K, Adachi Y, Ishida-Okawara A, Oharaseki T, Takahashi K, Naoe S, Suzuki K, Ohno N: Lethal and severe coronary arteritis in DBA\/2 mice induced by fungal pathogen, CAWS, Candida albicans water-soluble fraction. Atherosclerosis 2006; 186: 310-320.","DOI":"10.1016\/j.atherosclerosis.2005.08.014"},{"key":"4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2013\/543141","volume":"2013","author":"R Ohashi","year":"2013","unstructured":"4. Ohashi R, Fukazawa R, Watanabe M, Tajima H, Nagi-Miura N, Ohno N, Tsuchiya S, Fukuda Y, Ogawa S, Itoh Y: Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents. International journal of vascular medicine 2013; 2013: 10.","journal-title":"International Journal of Vascular Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/2090-2824","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Takahashi K, Oharaseki T, Yokouchi Y, Miura NN, Ohno N, Okawara AI, Murata H, Naoe S, Suzuki K: Administration of human immunoglobulin suppresses development of murine systemic vasculitis induced with Candida albicans water-soluble fraction: an animal model of Kawasaki disease. Mod Rheumatol 2010; 20: 160-167.","DOI":"10.3109\/s10165-009-0250-5"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Takahashi K, Oharaseki T, Nagao T, Yokouchi Y, Yamada H, Nagi-Miura N, Ohno N, Saji T, Okazaki T, Suzuki K: Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease. Pediatric rheumatology online journal 2011; 9: 30.","DOI":"10.1186\/1546-0096-9-30"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Hara T, Nakashima Y, Sakai Y, Nishio H, Motomura Y, Yamasaki S: Kawasaki disease: a matter of innate immunity. Clin Exp Immunol 2016; 186: 134-143.","DOI":"10.1111\/cei.12832"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Dinarello CA: A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur J Immunol 2011; 41: 1203-1217.","DOI":"10.1002\/eji.201141550"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M: IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1alpha and IL-1beta. Arterioscler Thromb Vasc Biol 2015; 35: 2605-2616.","DOI":"10.1161\/ATVBAHA.115.306475"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Lee Y, Schulte DJ, Shimada K, Chen S, Crother TR, Chiba N, Fishbein MC, Lehman TJ, Arditi M: Interleukin-1beta is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation 2012; 125: 1542-1550.","DOI":"10.1161\/CIRCULATIONAHA.111.072769"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Uchiyama M, Ohno N, Miura NN, Adachi Y, Aizawa MW, Tamura H, Tanaka S, Yadomae T: Chemical and immunochemical characterization of limulus factor G-activating substance of Candida spp. FEMS Immunol Med Microbiol 1999; 24: 411-420.","DOI":"10.1111\/j.1574-695X.1999.tb01313.x"},{"key":"12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00204-014-1405-5","volume":"90","author":"J Guo","year":"2016","unstructured":"12. Guo J, Shi T, Cui X, Rong Y, Zhou T, Zhang Z, Liu Y, Shen Y, Chen W: Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL\/6 mice. Archives of toxicology 2016; 90: 247-258.","journal-title":"Archiv fur Toxikologie Fuhner-Weilands Sammlung von Vergiftungsfallen","ISSN":"https:\/\/id.crossref.org\/issn\/0340-5761","issn-type":"print"},{"key":"13","unstructured":"13. Geiger T, Towbin H, Cosenti-Vargas A, Zingel O, Arnold J, Rordorf C, Glatt M, Vosbeck K: Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA\/1 mice and prevents the associated acute-phase response. Clin Exp Rheumatol 1993; 11: 515-522."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kibata T, Suzuki Y, Hasegawa S, Matsushige T, Kusuda T, Hoshide M, Takahashi K, Okada S, Wakiguchi H, Moriwake T, Uchida M, Ohbuchi N, Iwai T, Hasegawa M, Ichihara K, Yashiro M, Makino N, Nakamura Y, Ohga S: Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin. Int J Cardiol 2016; 214: 209-215.","DOI":"10.1016\/j.ijcard.2016.03.017"},{"key":"15","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(11)61930-2","volume":"379","author":"T Kobayashi","year":"2012","unstructured":"15. Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A, investigators Rsg: Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Lancet 2012; 379: 1613-1620.","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"16","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41598-017-18387-7","volume":"8","author":"M Mori","year":"2018","unstructured":"16. Mori M, Hara T, Kikuchi M, Shimizu H, Miyamoto T, Iwashima S, Oonishi T, Hashimoto K, Kobayashi N, Waki K, Suzuki Y, Otsubo Y, Yamada H, Ishikawa C, Kato T, Fuse S: Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial. Scientific reports 2018; 8: 1994.","journal-title":"Scientific Reports","ISSN":"https:\/\/id.crossref.org\/issn\/2045-2322","issn-type":"print"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Guidelines for Diagnosis and Management of Cardiovascular Sequelae in Kawasaki Disease (JCS 2013) -Digest Version- JCS Joint Working Group. Circ J 2013; https:\/\/www.jstage.jst.go.jp\/article\/circj\/78\/10\/78_CJ-66-0096\/_pdf. Accessed Dec3, 2018.","DOI":"10.1253\/circj.CJ-66-0096"},{"key":"18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1546-0096-12-26","volume":"12","author":"A Shafferman","year":"2014","unstructured":"18. Shafferman A, Birmingham JD, Cron RQ: High dose Anakinra for treatment of severe neonatal Kawasaki disease: a case report. Pediatric rheumatology online journal 2014; 12: 26.","journal-title":"Pediatric Rheumatology","ISSN":"https:\/\/id.crossref.org\/issn\/1546-0096","issn-type":"print"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Maury CP, Salo E, Pelkonen P: Circulating interleukin-1 beta in patients with Kawasaki disease. N Engl J Med 1988; 319: 1670-1671.","DOI":"10.1056\/NEJM198812223192515"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Fury W, Tremoulet AH, Watson VE, Best BM, Shimizu C, Hamilton J, Kanegaye JT, Wei Y, Kao C, Mellis S, Lin C, Burns JC: Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance. Hum Immunol 2010; 71: 865-873.","DOI":"10.1016\/j.humimm.2010.06.008"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nagi-Miura N, Shingo Y, Adachi Y, Ishida-Okawara A, Oharaseki T, Takahashi K, Naoe S, Suzuki K, Ohno N: Induction of coronary arteritis with administration of CAWS (Candida albicans water-soluble fraction) depending on mouse strains. Immunopharmacol Immunotoxicol 2004; 26: 527-543.","DOI":"10.1081\/IPH-200042295"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lehman TJ, Walker SM, Mahnovski V, McCurdy D: Coronary arteritis in mice following the systemic injection of group B Lactobacillus casei cell walls in aqueous suspension. Arthritis Rheum 1985; 28: 652-659.","DOI":"10.1002\/art.1780280609"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nishio H, Kanno S, Onoyama S, Ikeda K, Tanaka T, Kusuhara K, Fujimoto Y, Fukase K, Sueishi K, Hara T: Nod1 ligands induce site-specific vascular inflammation. Arterioscler Thromb Vasc Biol 2011; 31: 1093-1099.","DOI":"10.1161\/ATVBAHA.110.216325"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Hui-Yuen JS, Duong TT, Yeung RS: TNF-alpha is necessary for induction of coronary artery inflammation and aneurysm formation in an animal model of Kawasaki disease. J Immunol 2006; 176: 6294-6301.","DOI":"10.4049\/jimmunol.176.10.6294"},{"key":"25","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1161\/CIRCULATIONAHA.105.537530","volume":"112","author":"ME Rosenkranz","year":"2005","unstructured":"25. Rosenkranz ME, Schulte DJ, Agle LM, Wong MH, Zhang W, Ivashkiv L, Doherty TM, Fishbein MC, Lehman TJ, Michelsen KS, Arditi M: TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease. Circulation 2005; 112: 2966-2973.","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Miura NN, Komai M, Adachi Y, Osada N, Kameoka Y, Suzuki K, Ohno N: IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA\/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA\/N mice. J Immunol 2009; 183: 3417-3424.","DOI":"10.4049\/jimmunol.0802484"},{"key":"27","unstructured":"27. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB: Interleukin 1beta Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology 2016; 151: 1100-1104."}],"container-title":["Journal of Nippon Medical School"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/86\/2\/86_JNMS.2019_86-206\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T03:46:09Z","timestamp":1558755969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/86\/2\/86_JNMS.2019_86-206\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,26]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1272\/jnms.jnms.2019_86-206","relation":{},"ISSN":["1345-4676","1347-3409"],"issn-type":[{"value":"1345-4676","type":"print"},{"value":"1347-3409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,26]]}}}