{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:49:13Z","timestamp":1774583353461,"version":"3.50.1"},"reference-count":35,"publisher":"Medical Association of Nippon Medical School","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nippon Med Sch"],"published-print":{"date-parts":[[2020,2,15]]},"DOI":"10.1272\/jnms.jnms.2020_87-102","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T22:03:54Z","timestamp":1574892234000},"page":"7-12","source":"Crossref","is-referenced-by-count":10,"title":["Renal Complications after Hematopoietic Stem Cell Transplantation: Role of Graft-Versus-Host Disease in Renal Thrombotic Microangiopathy"],"prefix":"10.1272","volume":"87","author":[{"given":"Akiko","family":"Mii","sequence":"first","affiliation":[{"name":"Department of Nephrology, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"21","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"1. Niederwieser D, Baldomero H, Szer J, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transpl. 2016;51:1-8. doi: 10.1038\/bmt.2016.18","DOI":"10.1038\/bmt.2016.18"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2. Ando M. An overview of kidney disease following hematopoietic cell transplantation. Intern Med. 2018;57:1503-8. doi: 10.2169\/internalmedicine.9838-17","DOI":"10.2169\/internalmedicine.9838-17"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Ando M, Ohashi K, Akiyama H, et al. Chronic kidney disease in long-term survivors of myeloablative allogeneic haematopoietic cell transplantation: prevalence and risk factors. Nephrol Dial Transplant. 2010;25:278-82. doi: 10.1093\/ndt\/gfp485","DOI":"10.1093\/ndt\/gfp485"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hingorani SR. Renal complications of hematopoietic cell transplantation. N Engl J Med. 2016;374:2256-67.","DOI":"10.1056\/NEJMra1404711"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Shingai N, Morito T, Najima Y, et al. Early-onset acute kidney injury is a poor prognostic sign for allogeneic SCT recipients. Bone Marrow Transpl. 2015;50:1557-62. doi: 10.1038\/bmt.2015.188","DOI":"10.1038\/bmt.2015.188"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Mii A, Shimizu A, Masuda Y, et al. Renal thrombotic microangiopathy associated with chronic humoral graft versus host disease after hematopoietic stem cell transplantation. Pathol Int. 2011;61:34-41. doi: 10.1111\/j.1440-1827.2010.02608.x","DOI":"10.1111\/j.1440-1827.2010.02608.x"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Mii A, Shimizu A, Kaneko T, et al. Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Pathol Int. 2011;61:518-27. doi: 10.1111\/j.1440-1827.2011.02704.x","DOI":"10.1111\/j.1440-1827.2011.02704.x"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Mii A, Shimizu A, Kaneko T, Nakayama K, Yamaguchi H, Tsuruoka S. Renal thrombotic microangiopathy after hematopoietic stem cell transplantation: involvement of chronic graft-versus-host disease. Kidney Int Reports. 2018;3:743-7. doi: 10.1016\/j.ekir.2017.12.013","DOI":"10.1016\/j.ekir.2017.12.013"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Changsirikulchai S, Myerson D, Guthrie KA, Mcdonald GB, Alpers CE, Hingorani SR. Renal thrombotic microangiopathy after hematopoietic cell transplant: role of GVHD in pathogenesis. Clin J Am Soc Nephrol. 2009;4:345-53. doi: 10.2215\/CJN.02070508","DOI":"10.2215\/CJN.02070508"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Lopes JA, Jorge S, Silva S, et al. Acute renal failure following myeloablative autologous and allogeneic hematopoietic cell transplantation. Bone Marrow Transpl. 2006;38:707. doi: 10.1038\/sj.bmt.1705513","DOI":"10.1038\/sj.bmt.1705513"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Ando M, Mori J, Ohashi K, et al. A comparative assessment of the RIFLE, AKIN and conventional criteria for acute kidney injury after hematopoietic SCT. Bone Marrow Transpl. 2010;45:1427-34. doi: 10.1038\/bmt.2009.377","DOI":"10.1038\/bmt.2009.377"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Ellis MJ, Parikh CR, Inrig JK, Kanbay M, Patel UD. Chronic kidney disease after hematopoietic cell transplantation: a systematic review. Am J Transpl. 2008;8:2378-90. doi: 10.1111\/j.1600-6143.2008.02408.x","DOI":"10.1111\/j.1600-6143.2008.02408.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Shlipak MG, Fried LF, Cushman M, et al. Cardiovascular mortality risk in chronic kidney disease comparison of traditional and novel risk factors. J Amer Med Assoc. 2005;293:1737-45.","DOI":"10.1001\/jama.293.14.1737"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389:1238-52. doi: 10.1016\/S0140-6736 (16) 32064-5","DOI":"10.1016\/S0140-6736(16)32064-5"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Jo T, Arai Y, Kondo T, et al. Biology of blood and marrow transplantation chronic kidney disease in long-term survivors after allogeneic hematopoietic stem cell transplantation: retrospective analysis at a single institute. Biol Blood Marrow Transpl. 2017;23:2159-65. doi: 10.1016\/j.bbmt.2017.08.016","DOI":"10.1016\/j.bbmt.2017.08.016"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Hingorani SR, Seidel K, Lindner A, Aneja T, Schoch G, Mcdonald G. Albuminuria in hematopoietic cell transplantation patients: prevalence, clinical associations, and impact on survival. Biol Blood Marrow Transpl. 2008;14:1365-72. doi: 10.1016\/j.bbmt.2008.09.015","DOI":"10.1016\/j.bbmt.2008.09.015"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Hingorani S, Pao E, Stevenson P, et al. Changes in glomerular filtration rate and impact on long-term survival among adults after hematopoietic cell transplantation a prospective cohort study. Clin J Am Soc Nephrol. 2018;13:866-73. doi: 10.2215\/CJN.10630917","DOI":"10.2215\/CJN.10630917"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Luo XD, Liu QF, Zhang Y, et al. Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation: etiology and pathogenesis. Blood Cells Mol Dis. 2011;46:182-7.","DOI":"10.1016\/j.bcmd.2010.12.003"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Byrne-Dugan CJ, Collins AB, Lam AQ, Batal I. Membranous nephropathy as a manifestation of graft-versus-host disease: association with HLA antigen typing, phospholipase A2 receptor, and C4d. Am J Kidney Dis. 2014;64:987-93.","DOI":"10.1053\/j.ajkd.2014.09.001"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Rao S. Nephrotic syndrome in patients with peripheral blood stem cell transplant. Am J Kidney Dis. 2005;45:780-5. doi: 10.1053\/j.ajkd.2005.01.003","DOI":"10.1053\/j.ajkd.2005.01.003"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Brukamp K, Doyle AM, Bloom RD, Bunin N, Tomaszewski JE, Cizman B. Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease? Clin J Am Soc Nephrol. 2006;1:685-94. doi: 10.2215\/CJN.00380705","DOI":"10.2215\/CJN.00380705"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Seconi J, Watt V, Ritchie DS. Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells. Bone Marrow Transplant. 2003;32:447-50. doi: 10.1038\/sj.bmt.1704151","DOI":"10.1038\/sj.bmt.1704151"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Kusumi E, Kami M, Hara S, et al. Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: Possible involvement of graft-versus-host disease. Int J Hematol. 2008;87:225-30. doi: 10.1007\/s12185-008-0026-2","DOI":"10.1007\/s12185-008-0026-2"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Ferrara JLM, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009;373:1550-61. doi: 10.1016\/S0140-6736 (09) 60237-3","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Cooke KR, Luznik L, Sarantopoulos S, et al. The biology of chronic graft-versus-host disease: a task force report from the national institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2017;23:211-34. doi: 10.1016\/j.bbmt.2016.09.023","DOI":"10.1016\/j.bbmt.2016.09.023"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Kanamori H, Maruta A, Sasaki S, et al. Diagnostic value of hemostatic parameters in bone marrow transplant-associated thrombotic microangiopathy. Bone Marrow Transplant. 1998;21:705-9. doi: 10.1038\/sj.bmt.1701151","DOI":"10.1038\/sj.bmt.1701151"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Matsuda Y, Hara J, Osugi Y, et al. Serum levels of soluble adhesion molecules in stem cell transplantation-related complications. Bone Marrow Transplant. 2001;27:977-82. doi: 10.1038\/sj.bmt.1703026","DOI":"10.1038\/sj.bmt.1703026"},{"key":"28","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(02)08907-9","volume":"359","author":"BC Biedermann","year":"2002","unstructured":"28. Biedermann BC, Sahner S, Gregor M, et al. Mechanisms of disease endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet. 2002;359:2078-83.","journal-title":"The Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Biedermann BC. Vascular endothelium and graft-versus-host disease. Best Pract Res Clin Haematol. 2008;21:129-38. doi: 10.1016\/j.beha.2008.02.003","DOI":"10.1016\/j.beha.2008.02.003"},{"key":"30","unstructured":"30. Williams WW, Tolkoff-rubin N, Colvin RB. Clinical role of the renal transplant biopsy. Nat Rev Nephrol. 2013;8:110-21. doi: 10.1038\/nrneph.2011.213.Clinical"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Jodele S, Laskin BL, Dandoy CE, et al. A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev. 2015;29:191-204. doi: 10.1016\/j.blre.2014.11.001","DOI":"10.1016\/j.blre.2014.11.001"},{"key":"32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.tp.0000297998.33418.7e","volume":"85","author":"K Siami","year":"2008","unstructured":"32. Siami K, Kojouri K, Swisher KK, Selby GB, George JN, Laszik ZG. Thrombotic Microangiopathy after allogeneic hematopoietic stem cell transplantation: an autopsy study. Transplantation. 2008;85:22-8. doi: 10.1097\/01.tp.0000297998.33418.7e","journal-title":"Transplantation","ISSN":"https:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33. Jodele S, Fukuda T, Vinks A, et al. Eculizumab therapy in children with severe hematopoietic stem cell transplantation e associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2014;20:518-25. doi: 10.1016\/j.bbmt.2013.12.565","DOI":"10.1016\/j.bbmt.2013.12.565"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Higo S, Shimizu A, Masuda Y, et al. Acute graft-versus-host disease of the kidney in allogeneic rat bone marrow transplantation. PLoS One. 2014;9:e115399.","DOI":"10.1371\/journal.pone.0115399"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35. Niculescu F, Niculescu T, Nguyen P, et al. Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease. Exp Mol Pathol. 2005;79:136-45. doi: 10.1016\/j.yexmp.2005.03.007","DOI":"10.1016\/j.yexmp.2005.03.007"}],"container-title":["Journal of Nippon Medical School"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/87\/1\/87_JNMS.2020_87-102\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T03:46:52Z","timestamp":1584157612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jnms\/87\/1\/87_JNMS.2020_87-102\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,15]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1272\/jnms.jnms.2020_87-102","relation":{},"ISSN":["1345-4676","1347-3409"],"issn-type":[{"value":"1345-4676","type":"print"},{"value":"1347-3409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,15]]}}}