{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:59:55Z","timestamp":1780451995084,"version":"3.54.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"2","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2020,4,30]]},"abstract":"<jats:p>Zdecydowana wi\u0119kszo\u015b\u0107 nowych neuropeptyd\u00f3w posiada unikalne w\u0142a\u015bciwo\u015bci biochemiczne, a tak\u017ce szerokie spectrum aktywno\u015bci fizjologicznej realizowane w licznych szlakach neuronalnych, w tym w podwzg\u00f3rzu i w uk\u0142adzie limbicznym. Szczeg\u00f3lnie wartym uwagi wydaje si\u0119 stosunkowo niedawno odkryty i wci\u0105\u017c intensywnie badany czynnik regulatorowy i potencjalny modulator zachowa\u0144 \u017cywieniowych nesfatyna-1. Szereg nowych informacji na temat tego neuropeptydu pozwala obecnie uzna\u0107 go za potencjalnie istotny czynnik zaanga\u017cowany w patogenez\u0119 szeregu zr\u00f3\u017cnicowanych zaburze\u0144 psychicznych. Nie nale\u017cy zatem wykluczy\u0107, \u017ce rozwa\u017cana farmakomodulacja sygnalizacji tego neuropeptydu mo\u017ce by\u0107 potencjalnie pomocna w przysz\u0142ym leczeniu pewnych zaburze\u0144 neuropsychiatrycznych i metabolicznych takich jak jad\u0142owstr\u0119t psychiczny. Na dzie\u0144 dzisiejszy wyniki stosunkowo licznych bada\u0144 podstawowych i klinicznych wydaj\u0105 si\u0119 by\u0107 obiecuj\u0105ce niemniej  wszelkie mo\u017cliwe zastosowania wy\u017cej wymienionych neuropeptyd\u00f3w, a tak\u017ce ich agonist\u00f3w i antagonist\u00f3w nadal pozostaj\u0105 w obszarze spekulacji. Intensywne poszukiwanie selektywnych modulator\u00f3w ich znanych receptor\u00f3w jest jednak uzasadnione i mo\u017ce przyczyni\u0107 si\u0119 do otwarcia obiecuj\u0105cego rozdzia\u0142u w terapii zaburze\u0144 od\u017cywiania. W niniejszym artykule dokonano przegl\u0105du najnowszych doniesie\u0144 dotycz\u0105cych hipotetycznej roli nesfatyny-1 w szlakach neuronalnych zwi\u0105zanych z patofizjologi\u0105 jad\u0142owstr\u0119tu psychicznego.<\/jats:p>","DOI":"10.12740\/pp\/102659","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T19:18:52Z","timestamp":1590607132000},"page":"209-222","source":"Crossref","is-referenced-by-count":9,"title":["Nesfatin-1 in the neurochemistry of eating disorders"],"prefix":"10.12740","volume":"54","author":[{"given":"Artur","family":"Pa\u0142asz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Rojczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Siwiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Janas-Kozik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2020,4,30]]},"container-title":["Psychiatria Polska"],"original-title":["Nesfatyna-1 w neurochemii zaburze\u0144 od\u017cywiania"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-102659-81626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-102659-81626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:50:45Z","timestamp":1666075845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Nesfatin-1-in-the-neurochemistry-of-eating-disorders,102659,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["102659"],"URL":"https:\/\/doi.org\/10.12740\/pp\/102659","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]}}}