{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:46:34Z","timestamp":1790999194988,"version":"4.1.0"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"6","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:sec><jats:title>Cel pracy<\/jats:title><jats:p>Celem pracy by\u0142o oznaczenie i analiza korelacji pomi\u0119dzy st\u0119\u017ceniami wybranych metaloproteinaz oraz ich inhibitor\u00f3w (TIMP-1 i TIMP-2) w grupie os\u00f3b leczonych z powodu zespo\u0142u ot\u0119piennego i schizofrenii. W badaniu okre\u015blono st\u0119\u017cenie dw\u00f3ch kolagenaz oraz metaloendopeptydazy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Badaniem obj\u0119to 29 pacjent\u00f3w leczonych z powodu zespo\u0142u ot\u0119piennego o p\u00f3\u017anym pocz\u0105tku i po 25: os\u00f3b leczonych z powodu schizofrenii paranoidalnej oraz os\u00f3b bez zaburzenia psychicznego, zgodnych wiekowo z grupami badanymi. Objawy zespo\u0142u ot\u0119piennego oceniono za pomoc\u0105 kr\u00f3tkiej skali oceny stanu psychicznego, a objawy schizofrenii\u2013 za pomoc\u0105 skali objaw\u00f3w pozytywnych i negatywnych. Od uczestnik\u00f3w badania pobrano pr\u00f3bk\u0119 krwi i oznaczono st\u0119\u017cenie MMP-1, MMP-7, MMP-13, TIMP -1 i TIMP-2 w surowicy krwi metod\u0105 ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>U os\u00f3b z ot\u0119pieniem zaobserwowano: dwukrotny wzrost st\u0119\u017cenia MMP-1 i niewielki wzrost MMP-13 w por\u00f3wnaniu do pozosta\u0142ych grup, a tak\u017ce ni\u017csze st\u0119\u017cenie MMP-7 i TIMP-1 oraz wy\u017csze st\u0119\u017cenie TIMP-2 w por\u00f3wnaniu do os\u00f3b z grupy kontrolnej. Natomiast w grupie os\u00f3b leczonych z powodu schizofrenii w por\u00f3wnaniu do os\u00f3b z grupy kontrolnej wykazano ni\u017csze st\u0119\u017cenie MMP-7, wy\u017csze st\u0119\u017cenie TIMP-2 oraz nie wykazano r\u00f3\u017cnic w st\u0119\u017ceniu MMP-1, MMP-13 i TIMP-1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>U os\u00f3b z zespo\u0142em ot\u0119piennym o p\u00f3\u017anym pocz\u0105tku wykazano wzrost aktywno\u015bci kolagenolitycznej co mo\u017ce wskazywa\u0107 na nasilenie zjawiska remodelingu w obr\u0119bie o\u015brodkowego uk\u0142adu nerwowego w tej grupie pacjent\u00f3w. Odmienno\u015b\u0107 fluktuacji st\u0119\u017ce\u0144 badanych enzym\u00f3w oraz ich inhibitor\u00f3w w zespole ot\u0119piennym oraz schizofrenii wskazuje na ich r\u00f3\u017cny udzia\u0142 w patogenezie wy\u017cej wymienionych zaburze\u0144.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/126662","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T22:30:12Z","timestamp":1643927412000},"page":"1221-1233","source":"Crossref","is-referenced-by-count":7,"title":["Activity of selected metalloproteinases in neurodegenerative diseases of the central nervous system as exemplified by dementia and schizophrenia"],"prefix":"10.12740","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-7809","authenticated-orcid":false,"given":"Aneta","family":"Tylec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Ska\u0142ecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kocot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kurzepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2021,12,31]]},"container-title":["Psychiatria Polska"],"original-title":["Aktywno\u015b\u0107 wybranych metaloproteinaz w chorobach neurodegeneracyjnych o\u015brodkowego uk\u0142adu nerwowego na przyk\u0142adzie ot\u0119pienia i schizofrenii"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-126662-81771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-126662-81771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:48:50Z","timestamp":1666075730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Activity-of-selected-metalloproteinases-in-neurodegenerative-diseases-of-the-central,126662,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,31]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"alternative-id":["126662"],"URL":"https:\/\/doi.org\/10.12740\/pp\/126662","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,31]]}}}