{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:59:30Z","timestamp":1772092770098,"version":"3.50.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"3","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2024,6,30]]},"abstract":"<jats:p>Trazodon jest inhibitorem wychwytu zwrotnego i antagonist\u0105 receptor\u00f3w serotoninowych zarejestrowanym w leczeniu epizod\u00f3w depresji (major depressive disorder \u2013 MDD). Doustne formulacje leku zosta\u0142y obszernie zbadane i s\u0105 dost\u0119pne w kilku krajach \u015bwiata, jednak dane przemawiaj\u0105ce za stosowaniem postaci pozajelitowej s\u0105 nieliczne. Nasz przegl\u0105d narracyjny podsumowuje charakterystyk\u0119 farmakologiczn\u0105 i dane kliniczne dotycz\u0105ce pozajelitowej postaci trazodonu w zaburzeniach nastroju. Aby wyszuka\u0107 najwa\u017cniejsze publikacje skorzystano z baz danych PubMed i Web of Science. Kluczowe dane naukowe pochodz\u0105ce z czterech bada\u0144 oceniaj\u0105cych skuteczno\u015b\u0107 w MDD wskazuj\u0105, \u017ce trazodon by\u0142 dobrze tolerowany i skuteczny. W trzech pr\u00f3bach donoszono te\u017c o zastosowaniu poza wskazaniami rejestracyjnymi (off-label) w agitacji w przebiegu choroby dwubiegunowej, jednak fakt jednoczesnego stosowania innych lek\u00f3w m\u00f3g\u0142 by\u0107 czynnikiem zak\u0142\u00f3caj\u0105cym i wp\u0142yn\u0105\u0107 na wyniki. Ograniczona ilo\u015b\u0107 dost\u0119pnych danych wskazuje na skuteczno\u015b\u0107 trazodonu w postaci podawanej drog\u0105 pozajelitow\u0105 w MDD i pozwala uzna\u0107 trazodon jako odpowiedni wyb\u00f3r w przypadku pacjent\u00f3w w wysokim ryzyku manii zwi\u0105zanej ze stosowan\u0105 farmakoterapi\u0105.<\/jats:p>","DOI":"10.12740\/pp\/182933","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:57:47Z","timestamp":1721570267000},"page":"449-466","source":"Crossref","is-referenced-by-count":4,"title":["Clinical experience with parenteral trazodone in mood disorders: A literature review"],"prefix":"10.12740","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-1268","authenticated-orcid":false,"given":"Calogero","family":"Crapanzano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-1732","authenticated-orcid":false,"given":"Ilaria","family":"Casolaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-9663","authenticated-orcid":false,"given":"Anna Julia","family":"Krupa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2024,6,30]]},"container-title":["Psychiatria Polska"],"original-title":["Do\u015bwiadczenia kliniczne z trazodonem stosowanym drog\u0105 pozajelitow\u0105 w zaburzeniach nastroju: przegl\u0105d literatury"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-182933-112489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-182933-112489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:58:00Z","timestamp":1721570280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Clinical-experience-with-parenteral-trazodone-in-mood-disorders-A-literature-review,182933,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"alternative-id":["182933"],"URL":"https:\/\/doi.org\/10.12740\/pp\/182933","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]}}}