{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:26:05Z","timestamp":1790637965897,"version":"4.1.0"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"3","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2024,6,30]]},"abstract":"<jats:p>Polski standard leczenia racemiczn\u0105 ketamin\u0105 pacjent\u00f3w z zaburzeniami depresyjnymi- \nopracowany przez zesp\u00f3\u0142 roboczy powo\u0142any przez Konsultanta Krajowego w dziedzinie psychiatrii: Mimo szerokiej gamy dost\u0119pnych lek\u00f3w, a\u017c 1\/3 pacjent\u00f3w z depresj\u0105 nie odpowiada na standardowe leczenie przeciwdepresyjne, co rodzi potrzeb\u0119 ci\u0105g\u0142ego poszukiwania nowych skutecznych i bezpiecznych metod terapii. W ostatnich latach ponownie uwag\u0119 wielu ekspert\u00f3w zwr\u00f3ci\u0142a mo\u017cliwa rola nadaktywno\u015bci uk\u0142adu glutaminergicznego w etiopatogenezie depresji. Postulowano mo\u017cliwo\u015b\u0107 wykorzystania substancji o dzia\u0142aniu moduluj\u0105cym na uk\u0142ad glutaminergiczny w leczeniu zaburze\u0144 depresyjnych  m.in. znanego od lat anestetyku- ketaminy, b\u0119d\u0105cej niekompetycyjnym antagonist\u0105 receptor\u00f3w NMDA. Niniejsza praca podsumowuje wyniki  bada\u0144 dotycz\u0105cych skuteczno\u015bci i bezpiecze\u0144stwa stosowania  ketaminy racemicznej (podawanej do\u017cylnie) w leczeniu pacjent\u00f3w z objawami depresyjnymi zar\u00f3wno w przebiegu choroby afektywnej jedno- jak i dwubiegunowej, a tak\u017ce wychodz\u0105c naprzeciw oczekiwaniom wielu lekarzy psychiatr\u00f3w praktyk\u00f3w, chc\u0105cych poszerzy\u0107 wachlarz proponowanych swoim pacjentom metod terapii, przedstawia rekomendacje dotycz\u0105ce wskaza\u0144, przeciwskaza\u0144, \u015brodk\u00f3w ostro\u017cno\u015bci oraz samego schematu leczenia ketamin\u0105 do\u017cyln\u0105 pacjent\u00f3w z zaburzeniami nastroju.<\/jats:p>","DOI":"10.12740\/pp\/189494","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:57:47Z","timestamp":1721570267000},"page":"377-401","source":"Crossref","is-referenced-by-count":6,"title":["Polish standard of treatment with racemic ketamine for patients with depressive disorders developed by a Working Group appointed by the National Consultant in the field of psychiatry"],"prefix":"10.12740","volume":"58","author":[{"given":"Piotr","family":"Ga\u0142ecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-7057","authenticated-orcid":false,"given":"Katarzyna Maria","family":"Bli\u017aniewska-Kowalska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw Jerzy","family":"Cuba\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Depukat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mosio\u0142ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Rybakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Samochowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogus\u0142aw","family":"Sobolewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Szulc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2024,6,30]]},"container-title":["Psychiatria Polska"],"original-title":["Polski standard leczenia racemiczn\u0105 ketamin\u0105 pacjent\u00f3w z zaburzeniami depresyjnymi opracowany przez zesp\u00f3\u0142 roboczy powo\u0142any przez Konsultanta Krajowegow dziedzinie psychiatrii"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-189494-112491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-189494-112491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T13:57:47Z","timestamp":1721570267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Polish-standard-of-treatment-with-racemic-ketamine-for-patients-with-depressive-disorders,189494,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"alternative-id":["189494"],"URL":"https:\/\/doi.org\/10.12740\/pp\/189494","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]}}}