{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:47:36Z","timestamp":1754153256552,"version":"3.41.2"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:p>Choroba afektywna dwubiegunowa charakteryzuje si\u0119 nawracaj\u0105cymi epizodami depresji, manii, hipomanii lub mieszanymi. Wczesna diagnoza i kompleksowe leczenie, obejmuj\u0105ce farmakoterapi\u0119 oraz oddzia\u0142ywania psychospo\u0142eczne, wi\u0105\u017c\u0105 si\u0119 z korzystniejszym rokowaniem. Og\u00f3lne zasady stosowania lek\u00f3w w chorobie afektywnej dwubiegunowej u dzieci i m\u0142odzie\u017cy pozostaj\u0105 podobne jak w przypadku chorych doros\u0142ych. Podstawowymi lekami w chorobie afektywnej dwubiegunowej s\u0105 leki normotymiczne I i II generacji, przy czym ich skuteczno\u015b\u0107 oraz profil bezpiecze\u0144stwa r\u00f3\u017cni si\u0119 od os\u00f3b doros\u0142ych. Ponadto konieczne jest leczenie profilaktyczne, kt\u00f3re ma zapobiega\u0107 nawrotom. W leczeniu manii, a tak\u017ce w stanach mieszanych rekomenduje si\u0119 lit, aripiprazol, kwetiapin\u0119, risperidon, olanzapin\u0119, asenapin\u0119, ziprazidon. W leczeniu epizod\u00f3w depresji w przebiegu choroby afektywnej dwubiegunowej u dzieci i m\u0142odzie\u017cy eksperci rekomenduj\u0105 lurazydon w monoterapii lub preparat \u0142\u0105czony olanzapina + fluoksetyna. Chocia\u017c d\u0142ugotrwa\u0142e leczenie jest kluczowym aspektem post\u0119powania z dzie\u0107mi i m\u0142odzie\u017c\u0105 z chorob\u0105 afektywn\u0105 dwubiegunow\u0105, brakuje sp\u00f3jnych danych dotycz\u0105cych skuteczno\u015bci. Dane dotycz\u0105ce bezpiecze\u0144stwa wskazuj\u0105, \u017ce najcz\u0119\u015bciej zg\u0142aszanymi dzia\u0142aniami niepo\u017c\u0105danymi u dzieci i m\u0142odzie\u017cy leczonych lekami normotymicznymi s\u0105 dzia\u0142ania niepo\u017c\u0105dane ze strony przewodu pokarmowego i neurologiczne, podczas gdy stosowanie lek\u00f3w przeciwpsychotycznych jest zwi\u0105zane g\u0142\u00f3wnie z przyrostem masy cia\u0142a i sedacj\u0105.<\/jats:p>","DOI":"10.12740\/pp\/193400","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T19:14:50Z","timestamp":1753211690000},"page":"359-372","source":"Crossref","is-referenced-by-count":0,"title":["Bipolar disorder in children, adolescents and young adults. Part 2. Therapeutic management. Recommendations under the patronage of the Executive Board of the Polish Psychiatric Association, National Consultants in the field of Psychiatry and National Consultants in Child and Adolescent Psychiatry"],"prefix":"10.12740","volume":"59","author":[{"given":"Aleksandra","family":"Lewandowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Janas-Kozik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tyszkiewicz-Nwafor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ga\u0142ecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-009X","authenticated-orcid":false,"given":"Barbara","family":"Remberk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2025,6,30]]},"container-title":["Psychiatria Polska"],"original-title":["Zaburzenie dwubiegunowe u dzieci, m\u0142odzie\u017cy i m\u0142odych doros\u0142ych. Cz\u0119\u015b\u0107 2. Post\u0119powanie terapeutyczne. Rekomendacje pod patronatem Zarz\u0105du G\u0142\u00f3wnego Polskiego Towarzystwa Psychiatrycznego oraz Konsultant\u00f3w Krajowych w dziedzinie psychiatrii i psychiatrii dzieci i m\u0142odzie\u017cy"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-193400-127173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-193400-127173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T19:14:51Z","timestamp":1753211691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Bipolar-disorder-in-children-adolescents-and-young-adults-Part-2-Therapeutic-management,193400,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"alternative-id":["193400"],"URL":"https:\/\/doi.org\/10.12740\/pp\/193400","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"type":"print","value":"0033-2674"},{"type":"electronic","value":"2391-5854"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}