{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:55:47Z","timestamp":1791478547090,"version":"4.3.4"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"4","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"abstract":"<jats:sec>\n                    <jats:title>Cel pracy<\/jats:title>\n                    <jats:p>W prezentowanym badaniu przeanalizowano polimorfizm genu receptora dopaminy DRD2, kt\u00f3ry jest szeroko opisywany w literaturze jako zwi\u0105zany z poszukiwaniem dozna\u0144. Zaburzenia hazardowe (GD) maj\u0105 podobne mechanizmy biologiczne i objawy do zaburze\u0144 zwi\u0105zanych z u\u017cywaniem substancji (SUD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Metoda<\/jats:title>\n                    <jats:p>Grupa badana sk\u0142ada\u0142a si\u0119 z 307 uczestnik\u00f3w. W grupie przebadano 107 m\u0119\u017cczyzn z rozpoznaniem uzale\u017cnienia od hazardu i od amfetaminy oraz 200 m\u0119\u017cczyzn nieuzale\u017cnionych, bez zaburze\u0144 psychicznych - stanowi\u0142o grup\u0119 kontroln\u0105 (obie grupy poddano ocenie psychometrycznej przy u\u017cyciu kwestionariusza State-Trait Anxiety Inventory oraz NEO Five-Factor Personality Inventory oraz przebadani przez specjalist\u0119 psychiatr\u0119). Genomowe DNA wyekstrahowano z krwi \u017cylnej zgodnie ze standardowymi protoko\u0142ami. Oznaczenie genu polimorfizmu DRD4 Ex3 przeprowadzono przy u\u017cyciu techniki PCR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Wyniki<\/jats:title>\n                    <jats:p>U os\u00f3b uzale\u017cnionych od hazardu i amfetaminy z wy\u017cszym poziomem skali cechy STAI i wy\u017cszym poziomem skali Neurotyczno\u015bci, polimorfizm genu DRD4 Ex3 s\/s wyst\u0119powa\u0142 istotnie cz\u0119\u015bciej w por\u00f3wnaniu z grup\u0105 kontroln\u0105 z polimorfizmem s\/s oraz polimorfizmem l\/l i s\/l. Podobnie u os\u00f3b uzale\u017cnionych od hazardu i amfetaminy z wy\u017cszym poziomem skali cechy STAI i wy\u017cszym poziomem Neurotyczno\u015bci, polimorfizm genu DRD4 Ex3 s\/l wyst\u0119powa\u0142 istotnie cz\u0119\u015bciej w por\u00f3wnaniu do grupy kontrolnej z polimorfizmem s\/s. Wyniki wykaza\u0142y, \u017ce genotypy s\/s oraz s\/l wyst\u0119powa\u0142y istotnie cz\u0119\u015bciej u m\u0119\u017cczyzn uzale\u017cnionych od hazardu i amfetaminy ni\u017c w grupie kontrolnej, co mo\u017ce sugerowa\u0107 zwi\u0105zek tych wariant\u00f3w DRD4 Ex3 z podatno\u015bci\u0105 na uzale\u017cnienie.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Wnioski<\/jats:title>\n                    <jats:p>W przedstawionym badaniu widzimy, \u017ce uzale\u017cnienia nale\u017cy analizowa\u0107 wieloczynnikowo. Zaobserwowano korelacj\u0119 mi\u0119dzy polimorfizmem DRD4 a cechami osobowo\u015bci zwi\u0105zanymi z uzale\u017cnieniem.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12740\/pp\/205179","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:16:22Z","timestamp":1791476182000},"page":"635-653","source":"Crossref","is-referenced-by-count":0,"title":["Personality, dopamine, and addiction: the DRD4 Ex3 (VNTR) polymorphism and personality traits in men addicted to gambling and amphetamine"],"prefix":"10.12740","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3574-5726","authenticated-orcid":false,"given":"Agnieszka","family":"Boro\u0144","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7841-821X","authenticated-orcid":false,"given":"Remigiusz","family":"Rec\u0142aw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-5466","authenticated-orcid":false,"given":"Krzysztof","family":"Chmielowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3285-5313","authenticated-orcid":false,"given":"Jolanta","family":"Chmielowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-2141","authenticated-orcid":false,"given":"Aleksandra","family":"Stro\u0144ska-Pluta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142 Tomasz","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-5838","authenticated-orcid":false,"given":"Jolanta","family":"Masiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-2829","authenticated-orcid":false,"given":"Magdalena","family":"Gibas-Dorna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-4901","authenticated-orcid":false,"given":"Grzegorz","family":"Trybek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-520X","authenticated-orcid":false,"given":"Anna","family":"Grzywacz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2026,10,8]]},"container-title":["Psychiatria Polska"],"original-title":["Osobowo\u015b\u0107, dopamina i uzale\u017cnienie: polimorfizm DRD4 Ex3 (VNTR) a cechy osobowo\u015bci u m\u0119\u017cczyzn uzale\u017cnionych od hazardu i amfetaminy"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-205179-149116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-205179-149116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:16:24Z","timestamp":1791476184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Personality-dopamine-and-addiction-the-DRD4-Ex3-VNTR-polymorphism-and-personality,205179,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"alternative-id":["205179"],"URL":"https:\/\/doi.org\/10.12740\/pp\/205179","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}