{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:11:06Z","timestamp":1776082266858,"version":"3.50.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"abstract":"<jats:sec><jats:title>Cel<\/jats:title><jats:p>Zaburzenia mitochondrialne metabolizmu energetycznego (ZM) stanowi\u0105 niejednorodn\u0105 grup\u0119 chor\u00f3b, kt\u00f3re mog\u0105 ujawni\u0107 si\u0119 w ka\u017cdym wieku szerokim spektrum objaw\u00f3w klinicznych, w tym zaburze\u0144 psychicznych.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Celem niniejszej pracy by\u0142o scharakteryzowanie objaw\u00f3w psychicznych oraz diagnoza u pi\u0119ciu pacjent\u00f3w w wieku od 17 do 53 lat cierpi\u0105cych na zesp\u00f3\u0142 MELAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>U czterech pacjent\u00f3w cierpi\u0105cych na zesp\u00f3\u0142 MELAS stwierdzono obecno\u015b\u0107 mutacji 3243A&gt;G mitochondrialnego DNA (mtDNA), a u jednego pacjenta mutacj\u0119 12706T&gt;C mtDNA. W rodzinach trzech pacjent\u00f3w wyst\u0119powa\u0142y przypadki zespo\u0142u MELAS. U jednego pacjenta jako pierwszy objaw zespo\u0142u MELAS zdiagnozowano depresj\u0119. Depresja poprzedza\u0142a r\u00f3wnie\u017c incydent podobny do udaru u jednego pacjenta. Czterech pacjent\u00f3w cierpia\u0142o na zaburzenia funkcji poznawczych, stany spl\u0105tania wyst\u0105pi\u0142y u trzech pacjent\u00f3w. Jeden pacjent przejawia\u0142 objawy psychotyczne (podobne do schizofrenii).<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>Zaburzenia mitochondrialne zas\u0142uguj\u0105 na uwag\u0119 jako cz\u0119\u015b\u0107 diagnozy r\u00f3\u017cnicowej, szczeg\u00f3lnie gdy istnieje podejrzenie wyst\u0105pienia objaw\u00f3w chorobowych w innych grupach organ\u00f3w lub wyst\u0119powa\u0142y przypadki ZM w rodzinie.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/24062","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T08:21:50Z","timestamp":1422260510000},"page":"1035-1045","source":"Crossref","is-referenced-by-count":10,"title":["Psychiatric disturbances in five patients with MELAS syndrome"],"prefix":"10.12740","volume":"48","author":[{"given":"Martin","family":"Magner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Honzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marketa","family":"Tesarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Dvorakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Hansikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Raboch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2014,10,31]]},"container-title":["Psychiatria Polska"],"original-title":["Zaburzenia psychiczne u pi\u0119ciu pacjent\u00f3w cierpi\u0105cych\nna zesp\u00f3\u0142 MELAS"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-58007-2645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-58007-2645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T07:01:09Z","timestamp":1666076469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Zaburzenia-psychiczne-u-pieciu-pacjentow-cierpiacych-nna-zespol-MELAS,58007,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,31]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014]]}},"alternative-id":["58007"],"URL":"https:\/\/doi.org\/10.12740\/pp\/24062","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,31]]}}}