{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:34:32Z","timestamp":1780925672334,"version":"3.54.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2017,4,30]]},"abstract":"<jats:sec><jats:title>Cel pracy<\/jats:title><jats:p>Na podstawie danych literaturowych mo\u017cna przypuszcza\u0107, \u017ce niekt\u00f3re aminokwasy bior\u0105 udzia\u0142 w patogenezie zaburze\u0144 autystycznych. Celem badania by\u0142a ocena st\u0119\u017cenia aminokwas\u00f3w w osoczu krwi u ch\u0142opc\u00f3w z autyzmem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Badaniem obj\u0119to 27 ch\u0142opc\u00f3w z autyzmem  (w wieku 2-10 lat, grupa badana), u kt\u00f3rych wykluczono choroby metaboliczne oraz 13 zdrowych ch\u0142opc\u00f3w (w wieku 2-9 lat, grupa kontrolna). Ilo\u015bciowe oznaczenie wolnych aminokwas\u00f3w (egzogennych i endogennych) w osoczu krwi wykonano metod\u0105 wysokosprawnej chromatografii cieczowej z detekcj\u0105 UV\/VIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>\u015arednie st\u0119\u017cenie citruliny, kwasu \u03b1-aminomas\u0142owego, izoleucyny, leucyny, fenyloalaniny, tryptofanu oraz ornityny by\u0142o istotnie statystycznie ni\u017csze w grupie ch\u0142opc\u00f3w z autyzmem w por\u00f3wnaniu do grupy kontrolnej (odpowiednio: p&lt;0,03; p&lt;0,04; p&lt;0,02; p&lt;0,02; p&lt;0,05; p&lt;0,02, p&lt;0,05). Dla wymienionych aminokwas\u00f3w wykre\u015blono krzywe). Pola powierzchni pod krzywymi ROC (Receiver Operating Characteristic) dla tych aminokwas\u00f3w  wynosi\u0142y od 0,637 do 0,726. \u017baden z oznaczonych aminokwas\u00f3w nie r\u00f3\u017cnicowa\u0142 zdrowych dzieci od dzieci z autyzmem. Suma aminokwas\u00f3w egzogennych by\u0142a ni\u017csza w grupie badanej w por\u00f3wnaniu do grupy kontrolnej, jednak r\u00f3\u017cnica ta nie by\u0142a istotna statystycznie.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>Niski poziom aminokwas\u00f3w egzogennych u dzieci z autyzmem potwierdza udzia\u0142 tych aminokwas\u00f3w w zaburzeniach autystycznych. Jednak oznaczanie profilu aminokwas\u00f3w egzogennych w osoczu krwi nie mo\u017ce by\u0107 stosowane do diagnostyki autyzmu, mo\u017ce by\u0107 natomiast przydatne w opiece nad pacjentem.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/65046","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T06:53:41Z","timestamp":1493621621000},"page":"359-368","source":"Crossref","is-referenced-by-count":22,"title":["The amino acid profile in blood plasma of young boys with autism"],"prefix":"10.12740","volume":"51","author":[{"given":"Jolanta","family":"Bugajska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Berska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Wojtyto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Bik-Multanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Sztefko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2017,4,30]]},"container-title":["Psychiatria Polska"],"original-title":["Profil aminokwasowy osocza krwi ch\u0142opc\u00f3w z autyzmem"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-65046-81364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-65046-81364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:57:36Z","timestamp":1666076256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Profil-aminokwasowy-osocza-krwi-chlopcow-z-autyzmem,65046,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"alternative-id":["65046"],"URL":"https:\/\/doi.org\/10.12740\/pp\/65046","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,30]]}}}