{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:47:22Z","timestamp":1764784042887},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2017,12,30]]},"abstract":"<jats:sec><jats:title>Cel pracy<\/jats:title><jats:p>DRESS (reakcja polekowa z eozynofili\u0105 i zaj\u0119ciem narz\u0105d\u00f3w wewn\u0119trznych) jest zaliczany do typowych reakcji nadwra\u017cliwo\u015bci na leki. Zesp\u00f3\u0142 mo\u017ce by\u0107 wywo\u0142any prze ka\u017cdy lek. Na obraz kliniczny schorzenia sk\u0142adaj\u0105 si\u0119 trzy grupy objaw\u00f3w: zmiany sk\u00f3rne, nieprawid\u0142owo\u015bci hematologiczne oraz objawy zaj\u0119cia narz\u0105d\u00f3w wewn\u0119trznych.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Wykonano badanie retrospektywne na grupie 261 pacjent\u00f3w z reakcjami nadwra\u017cliwo\u015bci na leki hospitalizowanych w Klinice Dermatologii w latach 2004-2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>Zesp\u00f3\u0142 DRESS zdiagnozowano u 10 chorych w\u015br\u00f3d 261 pacjent\u00f3w z reakcjami nadwra\u017cliwo\u015bci na leki. Lekiem, kt\u00f3ry by\u0142 najcz\u0119stszym czynnikiem etiologicznym zespo\u0142u by\u0142a karbamazepina - 6 pacjent\u00f3w (60%). Lamotrygina by\u0142a przyczyn\u0105 DRESS w 2 przypadkach, natomiast oxykarbamazepina  oraz deksketoprofen w 1 przypadku. Zmiany sk\u00f3rne wyst\u0105pi\u0142y u 100% badanych. By\u0142a to g\u0142\u00f3wnie rumieniowa zlewna wysypka, kt\u00f3rej towarzyszy\u0142 obrz\u0119k twarzy. Eozynofilia wyst\u0105pi\u0142a u 80% pacjent\u00f3w, natomiast atypowe limfocyty odnotowano u 40% przypadk\u00f3w. Najcz\u0119\u015bciej zaj\u0119tym narz\u0105dem by\u0142a w\u0105troba.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>Mo\u017cliwo\u015b\u0107 wyst\u0105pienia DRESS nale\u017cy wzi\u0105\u0107 pod uwag\u0119 w diagnostyce r\u00f3\u017cnicowej objaw\u00f3w niepo\u017c\u0105danych wyst\u0119puj\u0105cych g\u0142\u00f3wnie po lekach przeciwdrgawkowych. Wczesna diagnoza pozwoli unikn\u0105\u0107 wielu niebezpiecznych powik\u0142a\u0144 oraz d\u0142ugotrwa\u0142ej hospitalizacji.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/74358","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T12:10:56Z","timestamp":1514722256000},"page":"1079-1093","source":"Crossref","is-referenced-by-count":10,"title":["A retrospective study of DRESS \u2013 drug reaction with eosinophilia and systemic symptoms"],"prefix":"10.12740","volume":"51","author":[{"given":"Dorota","family":"Mehrholz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Herstowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Nowicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw","family":"Cuba\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wioletta","family":"Bara\u0144ska-Rybak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2017,12,30]]},"container-title":["Psychiatria Polska"],"original-title":["Analiza retrospektywna DRESS \u2013 reakcji polekowej z eozynofili\u0105 i powik\u0142aniami narz\u0105dowymi"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-74358-81418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-74358-81418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:56:12Z","timestamp":1666076172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Analiza-retrospektywna-DRESS-reakcji-polekowej-z-eozynofilia-i-powiklaniami-narzadowymi,74358,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,30]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017]]}},"alternative-id":["74358"],"URL":"https:\/\/doi.org\/10.12740\/pp\/74358","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,30]]}}}