{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:26:20Z","timestamp":1791325580009,"version":"4.3.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"4","license":[{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T00:00:00Z","timestamp":1567209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2019,8,31]]},"abstract":"<jats:p>Zaburzenia ze spektrum autyzmu (ASD - autism spectrum disorders) dotykaj\u0105 ludzi ze wszystkich rejon\u00f3w naszego globu, niezale\u017cnie od narodowo\u015bci, stopy \u017cyciowej czy grupy spo\u0142ecznej. Obecnie uznaj\u0119 si\u0119, \u017ce etiopatogeneza ASD ma charakter wieloczynnikowy, poniewa\u017c nie ma jednoznacznej przyczyny wyst\u0119powania tego zaburzenia. Wed\u0142ug literatury ASD mo\u017ce wynika\u0107 z wad genetycznych, neurologicznych, metabolicznych, czy nara\u017cenia na czynniki \u015brodowiskowe. Istnieje szereg hipotez staraj\u0105cych si\u0119 wyt\u0142umaczy\u0107 nasilenie objaw\u00f3w emocjonalnych, behawioralnych czy podwy\u017cszony pr\u00f3g wra\u017cliwo\u015bci sensorycznej, kt\u00f3re charakterystyczne s\u0105 dla os\u00f3b z ASD. Sugeruje si\u0119, \u017ce neurologiczne zmiany mog\u0105 by\u0107 wywo\u0142ane stresem oksydacyjnym wyst\u0119puj\u0105cym we wczesnym okresie rozwoju tkanki m\u00f3zgowej i obni\u017con\u0105 barier\u0105 antyoksydacyjn\u0105. Z uwagi na cz\u0119sto wyst\u0119puj\u0105ce nieprawid\u0142owo\u015bci w syntezie neuroprzeka\u017anik\u00f3w, autyzm badany jest pod k\u0105tem zaburze\u0144 przebiegu kluczowych dla \u017cycia biochemicznych proces\u00f3w metylacji i transsulfuracji. Znalezienie biomarkera \u015bwiadcz\u0105cego o zaburzeniu r\u00f3wnowagi oksydacyjno-redukcyjnej, patologii szlaku metylacyjnego lub innej przyczyny mog\u0142oby by\u0107 istotnym narz\u0119dziem do oceny diagnostycznej i podstaw\u0105 do podj\u0119cia indywidualnej metody leczenia chorych z r\u00f3\u017cnym stopniem zaawansowania. Niniejsza praca zawiera przegl\u0105d potencjalnych wska\u017anik\u00f3w biologicznych dla ASD, dokonany pod k\u0105tem wyst\u0119puj\u0105cego stresu oksydacyjnego oraz cyklu metylacji i transsulfuracji.<\/jats:p>","DOI":"10.12740\/pp\/89948","type":"journal-article","created":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T13:23:26Z","timestamp":1568467406000},"page":"771-788","source":"Crossref","is-referenced-by-count":24,"title":["Autism spectrum disorder (ASD) \u2013 biomarkers of oxidative stress and methylation and transsulfuration cycle"],"prefix":"10.12740","volume":"53","author":[{"given":"Aleksandra","family":"Walig\u00f3ra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Walig\u00f3ra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kozarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Damasiewicz-Bodzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Gorczyca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Tyrpie\u0144-Golder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2019,8,31]]},"container-title":["Psychiatria Polska"],"original-title":["Zaburzenia ze spektrum autyzmu (ASD) \u2013 biomarkery stresu oksydacyjnego oraz cyklu metylacji i transsulfuracji"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-89948-81568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-89948-81568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:51:43Z","timestamp":1666075903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Autism-spectrum-disorder-ASD-biomarkers-of-oxidative-stress-and-methylation-and-transsulfuration,89948,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,31]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"alternative-id":["89948"],"URL":"https:\/\/doi.org\/10.12740\/pp\/89948","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,31]]}}}