{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:33:02Z","timestamp":1791952382146,"version":"4.3.4"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"2","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:p>Zespo\u0142y ot\u0119pienne s\u0105 problemem nie tylko os\u00f3b starszych. Ot\u0119pienie o wczesnym pocz\u0105tku (ang. early-onset dementia, EOD) rozpoczyna si\u0119 poni\u017cej 65 roku \u017cycia. Stanowi 4-10% wszystkich przypadk\u00f3w ot\u0119pie\u0144. EOD wywiera istotne konsekwencje psychospo\u0142eczne, dotyka bowiem ludzi w ich najbardziej produktywnych latach \u017cycia, maj\u0105cych liczne obowi\u0105zki rodzinne, zawodowe i spo\u0142eczne. Istnieje wiele chor\u00f3b, kt\u00f3re zidentyfikowano jako przyczyn\u0119 EOD. W\u015br\u00f3d nich najcz\u0119\u015bciej wymienia si\u0119 chorob\u0119 Alzheimera, ot\u0119pienie naczyniowe, ot\u0119pienie czo\u0142owo-skroniowe, ot\u0119pienie z cia\u0142kami Lewy'ego, urazowe  uszkodzenie m\u00f3zgu,  ot\u0119pienie alkoholowe, chorob\u0119 Huntingtona, chorob\u0119 Parkinsona, ot\u0119pienie mieszane, chorob\u0119 Creutzfeldta \u2013 Jakoba i zesp\u00f3\u0142 Downa. Wi\u0119kszo\u015b\u0107 bada\u0144 wykaza\u0142a chorob\u0119 Alzheimera jako najcz\u0119stsz\u0105 etiologi\u0119 EOD. Artyku\u0142 prezentuje przypadek 33-letniego chorego hospitalizowanego w Klinice Neurologii w Zabrzu, z post\u0119puj\u0105cymi od oko\u0142o 15 miesi\u0119cy zaburzeniami funkcji poznawczych, zaburzeniami mowy i cechami zespo\u0142u pozapiramidowego parkinsonowskiego. MR g\u0142owy uwidoczni\u0142 wyra\u017anie zaznaczone zaniki korowe i podkorowe, zw\u0142aszcza p\u0142at\u00f3w ciemieniowych i skroniowych. W p\u0142ynie m\u00f3zgowo-rdzeniowym wykazano obni\u017cony poziom \u03b2-amyloidu oraz znacznie podwy\u017cszony poziom P-tau. U chorego rozpoznano chorob\u0119 Alzheimera o wczesnym pocz\u0105tku, co potwierdzi\u0142o badanie genetyczne - zidentyfikowano zmian\u0119 sekwencji w genie preseniliny 1 w uk\u0142adzie heterozygotycznym.<\/jats:p>","DOI":"10.12740\/pp\/onlinefirst\/114122","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T13:37:45Z","timestamp":1579441065000},"page":"323-330","source":"Crossref","is-referenced-by-count":2,"title":["Early onset Alzheimer\u2019s disease \u2013 a case study"],"prefix":"10.12740","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-8240","authenticated-orcid":false,"given":"Beata","family":"\u0141abuz-Roszak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Torbus-Paluszczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Becelewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Becelewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Dobrakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Pierzcha\u0142a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2021,4,30]]},"container-title":["Psychiatria Polska"],"original-title":["Choroba Alzheimera o wczesnym pocz\u0105tku \u2013 opis przypadku"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-114122-81720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-114122-81720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:49:37Z","timestamp":1666075777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Early-onset-Alzheimer-s-disease-a-case-study,114122,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"alternative-id":["114122"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/114122","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]}}}