{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:44:16Z","timestamp":1793371456808,"version":"4.5.0"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"4","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2022,8,31]]},"abstract":"<jats:p>Zesp\u00f3\u0142 stresu pourazowego (Post-Traumatic Stress Disorder, PTSD) jest powszechnie wyst\u0119puj\u0105cym zaburzeniem psychicznym powstaj\u0105cym na skutek traumatycznych do\u015bwiadcze\u0144. Pomimo wielu dost\u0119pnych mo\u017cliwo\u015bci pomocy, obejmuj\u0105cych zar\u00f3wno farmakoterapi\u0119, jak i psychoterapi\u0119, dzia\u0142ania te niejednokrotnie nie przynosz\u0105 oczekiwanych rezultat\u00f3w. W ci\u0105gu ostatnich lat przemys\u0142 farmaceutyczny nie by\u0142 w stanie zaoferowa\u0107 nowych opartych na wielu mechanizmach dzia\u0142ania rozwi\u0105za\u0144, st\u0105d uwaga cz\u0119\u015bci badaczy skierowa\u0142a si\u0119 w stron\u0119 zsyntezowanych przed laty, a nast\u0119pnie zdelegalizowanych \u015brodk\u00f3w psychoaktywnych. Aktualnie przeprowadzane s\u0105 pr\u00f3by kliniczne z zastosowaniem metylenodioksymetaamfetaminy (MDMA) jako zwi\u0105zku wspomagaj\u0105cego psychoterapi\u0119 prowadzon\u0105 w nurcie poznawczo-behawioralnym, kt\u00f3rej przez ameryka\u0144sk\u0105 Agencj\u0119 \u017bywno\u015bci i Lek\u00f3w (Food and Drug Administration, FDA) ze wzgl\u0119du na dotychczas uzyskane wyniki, zosta\u0142o przypisane znaczenie terapii prze\u0142omowej (Breakthrough Therapy). Prezentowane przez autor\u00f3w informacje, przedstawiaj\u0105c mechanizmy dzia\u0142ania, uzasadniaj\u0105 jego terapeutyczne zastosowanie i opisuj\u0105 przebieg leczenia, a tak\u017ce konfrontuj\u0105 si\u0119 z potencjalnymi zagro\u017ceniami wynikaj\u0105cymi z przyjmowania tej substancji. Je\u017celi aktualnie trwaj\u0105ce badania 3. fazy zako\u0144cz\u0105 si\u0119 oczekiwanymi rezultatami, spe\u0142niaj\u0105c odpowiednie kryteria efektywno\u015bci, leczenie to b\u0119dzie mog\u0142o by\u0107 zatwierdzone przez FDA najwcze\u015bniej w 2022 roku.<\/jats:p>","DOI":"10.12740\/pp\/onlinefirst\/133919","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T19:37:15Z","timestamp":1621453035000},"page":"823-836","source":"Crossref","is-referenced-by-count":6,"title":["Will MDMA-assisted psychotherapy become a breakthrough in treatment-resistant post-traumatic stress disorder? A critical narrative review."],"prefix":"10.12740","volume":"56","author":[{"given":"Sandra","family":"Szafoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-393X","authenticated-orcid":false,"given":"Gniewko","family":"Wi\u0119ckiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-0063","authenticated-orcid":false,"given":"Robert","family":"Pudlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-7988","authenticated-orcid":false,"given":"Piotr","family":"Gorczyca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-7118","authenticated-orcid":false,"given":"Magdalena","family":"Piegza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2022,8,31]]},"container-title":["Psychiatria Polska"],"original-title":["Czy psychoterapia wspomagana metylenodioksymetaamfetamin\u0105 (MDMA) oka\u017ce si\u0119 prze\u0142omowa w terapii opornego na leczenie zespo\u0142u stresu pourazowego? Krytyczny przegl\u0105d narracyjny"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-133919-81877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-133919-81877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T17:50:02Z","timestamp":1666547402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Will-MDMA-assisted-psychotherapy-become-a-breakthrough-in-treatment-resistant-post,133919,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,31]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"alternative-id":["133919"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/133919","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,31]]}}}