{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:20:42Z","timestamp":1773778842220,"version":"3.50.1"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"3","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2022,6,30]]},"abstract":"<jats:p>Uzale\u017cnienie od alkoholu jest jednym z najcz\u0119stszych problem\u00f3w zdrowotnych. Przewlek\u0142a konsumpcja du\u017cych dawek alkoholu etylowego prowadzi do licznych zmian adaptacyjnych w o\u015brodkowym i obwodowym uk\u0142adzie nerwowym, w tym przede wszystkim do zmniejszenia aktywno\u015bci hamuj\u0105cych szlak\u00f3w GABA-ergicznych i wzrostu aktywno\u015bci pobudzaj\u0105cych szlak\u00f3w glutaminergicznych. W przypadku odstawienia alkoholu nawet u po\u0142owy pacjent\u00f3w mo\u017ce rozwin\u0105\u0107 si\u0119 alkoholowy zesp\u00f3\u0142 abstynencyjny (AZA). Niniejsze opracowanie zawiera zalecenia Polskiego Towarzystwa Psychiatrycznego i Sekcji Farmakoterapii Polskiego Towarzystwa Bada\u0144 nad Uzale\u017cnieniami dotycz\u0105ce farmakoterapii alkoholowych zespo\u0142\u00f3w abstynencyjnych. W pracy przedstawiono etiopatogenez\u0119, mechanizmy neuroprzeka\u017anikowe i receptorowe, objawy i kryteria diagnostyczne AZA, leki stosowane w terapii alkoholowych zespo\u0142\u00f3w abstynencyjnych, post\u0119powanie w niepowik\u0142anych i powik\u0142anych alkoholowych zespo\u0142ach abstynencyjnych, om\u00f3wiono post\u0119powanie w populacjach specjalnych. Lekami pierwszego rzutu w leczeniu AZA s\u0105 benzodiazepiny (BDZ). Wi\u0119kszo\u015b\u0107 bada\u0144 nie wykaza\u0142a przewagi kt\u00f3rejkolwiek substancji z grupy BDZ w leczeniu AZA. Decyzja o wyborze preparatu powinna wynika\u0107 z ich w\u0142a\u015bciwo\u015bci farmakokinetycznych, wsp\u00f3\u0142wyst\u0119puj\u0105cych chor\u00f3b oraz aktualnego stanu pacjenta. Najcz\u0119\u015bciej stosowanymi BDZ s\u0105 diazepam, lorazepam, oksazepam i klorazepat.<\/jats:p>","DOI":"10.12740\/pp\/onlinefirst\/149321","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T07:56:46Z","timestamp":1655539006000},"page":"433-452","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacotherapy of alcohol withdrawal syndromes \u2013 Recommendations of the Polish Psychiatric Association and the Pharmacotherapy Section of the Polish Society for Addiction Research"],"prefix":"10.12740","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0642-6075","authenticated-orcid":false,"given":"Pawe\u0142","family":"Mierzejewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw","family":"Bie\u0144kowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Jakubczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Samochowiec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Silczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Wojnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2022,6,30]]},"container-title":["Psychiatria Polska"],"original-title":["Farmakoterapia alkoholowych zespo\u0142\u00f3w abstynencyjnych \u2013 zalecenia Polskiego Towarzystwa Psychiatrycznego i Sekcji Farmakoterapii Polskiego Towarzystwa Bada\u0144 nad Uzale\u017cnieniami"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-149321-82675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-149321-82675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T18:14:14Z","timestamp":1666548854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Pharmacotherapy-of-alcohol-withdrawal-syndromes-Recommendations-of-the-Polish-Psychiatric,149321,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"alternative-id":["149321"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/149321","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}