{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:33:53Z","timestamp":1792445633178,"version":"4.5.0"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"6","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2023,12,31]]},"abstract":"<jats:p>Wortioksetyna jest lekiem przeciwdepresyjnym o unikatowym profilu dzia\u0142a\u0144 receptorowych. Zakres aktywno\u015bci farmakodynamicznej wortioksetyny wi\u0105\u017ce si\u0119 nie tylko z modulacj\u0105 przeka\u017anictwa serotoninergicznego, ale tak\u017ce noradrenergicznego i dopaminergicznego. Jednocze\u015bnie charakterystyka farmakokinetyczna leku warunkuje jego wysok\u0105 tolerancj\u0119 i bezpiecze\u0144stwo, kt\u00f3re obserwowano tak\u017ce w\u015br\u00f3d pacjent\u00f3w w podesz\u0142ym wieku lub u os\u00f3b obci\u0105\u017conych schorzeniami somatycznymi. Celem tej pracy jest podsumowanie wiedzy pochodz\u0105cej z najnowszych bada\u0144 oceniaj\u0105cych efekty leczenia wortioksetyn\u0105. Skuteczno\u015b\u0107 wortioksetyny w terapii depresji potwierdzono w wielu badaniach otwartych, randomizowanych pr\u00f3bach z grup\u0105 kontrol\u0105 oraz ich metaanalizach. Najnowsze badania wskazuj\u0105 ponadto, \u017ce lek ten pozwala chorym z depresj\u0105 nie tylko na osi\u0105gni\u0119cie remisji objawowej, ale tak\u017ce na uzyskanie poprawy hedonii oraz funkcjonowania poznawczego i zawodowego. Opisywano tak\u017ce badania potwierdzaj\u0105ce skuteczno\u015b\u0107 wortioksetyny w leczeniu os\u00f3b, kt\u00f3re do\u015bwiadczy\u0142y traumy, pacjent\u00f3w z depresj\u0105 w przebiegu choroby dwubiegunowej, a tak\u017ce chorych w wieku podesz\u0142ym. Wortioksetyna charakteryzuje si\u0119 korzystnym profilem tolerancji, rzadko powoduj\u0105c powa\u017cne dzia\u0142ania niepo\u017c\u0105dane i wysokim bezpiecze\u0144stwem terapii.<\/jats:p>","DOI":"10.12740\/pp\/onlinefirst\/151570","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T14:09:13Z","timestamp":1667484553000},"page":"1109-1126","source":"Crossref","is-referenced-by-count":26,"title":["Vortioxetine \u2013 pharmacological properties and use in mood disorders. The current state of knowledge"],"prefix":"10.12740","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-9663","authenticated-orcid":false,"given":"Anna Julia","family":"Krupa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Wojtasik-Bakalarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-1895","authenticated-orcid":false,"given":"Marcin","family":"Siwek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2023,12,31]]},"container-title":["Psychiatria Polska"],"original-title":["Wortioksetyna \u2013 w\u0142a\u015bciwo\u015bci farmakologiczne i zastosowanie w zaburzeniach nastroju. Aktualny stan wiedzy"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-151570-84827","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-151570-84827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T05:34:41Z","timestamp":1708148081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Vortioxetine-pharmacological-properties-and-use-in-mood-disorders-The-current-state,151570,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,31]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"alternative-id":["151570"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/151570","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,31]]}}}