{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:57:21Z","timestamp":1764093441310,"version":"3.45.0"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"5","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:sec>\n                    <jats:title>Cel pracy<\/jats:title>\n                    <jats:p>Grzyby z rodzaju Amanita s\u0105 uwa\u017cane za jedne z najbardziej toksycznych, powoduj\u0105cych powa\u017cne zatrucia, cz\u0119sto ko\u0144cz\u0105ce si\u0119 \u015bmierci\u0105. Jednak\u017ce, spo\u015br\u00f3d 707 opisanych gatunk\u00f3w, jedynie kilkana\u015bcie zawiera toksyczne oktapeptydy sklasyfikowane jako amanitotoksyny i falotoksyny. Wi\u0119kszo\u015b\u0107 przedstawicieli tego rodzaju uznana jest za gatunki niejadalne, nieliczne z kolei to przyk\u0142ady smacznych gatunk\u00f3w jadalnych. Amanita muscaria i Amanita pantherina to gatunki truj\u0105ce maj\u0105ce znacz\u0105cy etnomykologiczny wp\u0142yw na ewolucj\u0119 i socjologi\u0119 cz\u0142owieka mi\u0119dzy innymi ze wzgl\u0119du na dzia\u0142anie psychoaktywne. \nCelem pracy by\u0142o uzyskanie w warunkach laboratoryjnych myceli\u00f3w dw\u00f3ch gatunk\u00f3w A. muscaria i A. pantherina z wykorzystaniem 10 L bioreaktor\u00f3w z systemem air-lift oraz ocena uzyskanego materia\u0142u grzybowego jako surowca farmaceutycznego zawieraj\u0105cego muscymol oraz inne zwi\u0105zki biologicznie aktywne o potencjalnym znaczeniu w profilaktyce depresji.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Metoda<\/jats:title>\n                    <jats:p>Otrzyman\u0105 biomas\u0119 analizowano metod\u0105 RP\u2013HPLC oraz ASA pod wzgl\u0119dem zawarto\u015bci zwi\u0105zk\u00f3w organicznych (zwi\u0105zki indolowe, sterole, lowastatyna, ergotioneina, muscymol, kwas ibotenowy) i biopierwiastk\u00f3w.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Wyniki<\/jats:title>\n                    <jats:p>Na podstawie otrzymanych rezultat\u00f3w mo\u017cna wnioskowa\u0107, \u017ce mycelium A. muscaria zawiera szereg zwi\u0105zk\u00f3w bioaktywnych takich jak lowastatyna, ergotioneina czy 5-hydroksy-L-tryptofan w wy\u017cszych zawarto\u015bciach ni\u017c A. pantherina.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Wnioski<\/jats:title>\n                    <jats:p>Przeprowadzone w pracy oznaczenia muscymolu i innych dot\u0105d nieanalizowanych substancji bioaktywnych w biomasie otrzymanej w warunkach in vitro oraz por\u00f3wnawczo w owocnikach mog\u0105 przyczyni\u0107 si\u0119 do wykazania potencja\u0142u tych gatunk\u00f3w w leczeniu depresji, jednak konieczne s\u0105 dalsze badania eksperymentalne, w tym pr\u00f3by in vitro, a nast\u0119pnie badania kliniczne.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.12740\/pp\/onlinefirst\/193251","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T14:55:26Z","timestamp":1736866526000},"page":"827-842","source":"Crossref","is-referenced-by-count":0,"title":["Role of mycelia derived from in vitro cultures of Amanita spp. as a potential source of bioactive compounds with therapeutic potential for the mitigation and management of depressive disorders"],"prefix":"10.12740","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-211X","authenticated-orcid":false,"given":"Katarzyna","family":"Ka\u0142a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Su\u0142kowska-Ziaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Piotrowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Gajda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"S\u0119kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Hnatyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lazur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Muszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2025,10,31]]},"container-title":["Psychiatria Polska"],"original-title":["Czy mycelia z kultur in vitro Amanita muscaria i Amanita pantherina versus owocniki mog\u0105 by\u0107 potencjalnym \u017ar\u00f3d\u0142em substancji w profilaktyce i terapii depresji"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-193251-126365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-193251-126365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:52:34Z","timestamp":1764093154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Role-of-mycelia-derived-from-in-vitro-cultures-of-Amanita-spp-as-a-potential-source,193251,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"alternative-id":["193251"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/193251","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"type":"print","value":"0033-2674"},{"type":"electronic","value":"2391-5854"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}