{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T16:18:03Z","timestamp":1777825083538,"version":"3.51.4"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"abstract":"<jats:sec><jats:title>Cel<\/jats:title><jats:p>Rosn\u0105ca liczba danych sugeruje, \u017ce st\u0119\u017cenie magnezu mo\u017ce pe\u0142ni\u0107 rol\u0119 markera du\u017cej depresji (ang. major depressive disorder \u2013 MDD), jednak wnioski p\u0142yn\u0105ce z bada\u0144 klinicznych pozostaj\u0105 niejednoznaczne. Celem prezentowanego badania by\u0142o przeprowadzenie oceny st\u0119\u017ce\u0144 magnezu w surowicy krwi pacjent\u00f3w z MDD (w aktywnej fazie choroby lub w remisji) oraz analiza roli poziomu magnezu jako potencjalnego markera tego schorzenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Badanie kliniczno-kontrolne, w ramach kt\u00f3rego przebadano 69 pacjent\u00f3w w trakcie epizodu depresyjnego, 45 w remisji objawowej oraz 50 zdrowych ochotnik\u00f3w. Pomiaru st\u0119\u017cenia magnezu dokonano metod\u0105 p\u0142omieniowej atomowej spektrometrii absorpcyjnej (FAAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>\u015arednie st\u0119\u017cenie magnezu w surowicy krwi pacjent\u00f3w, w fazie depresyjnej by\u0142o statystycznie wy\u017csze w odniesieniu do grupy kontrolnej. Poziom magnezu u pacjent\u00f3w w fazie remisji nie r\u00f3\u017cni\u0142 si\u0119 istotnie od st\u0119\u017cenia notowanego u zdrowych ochotnik\u00f3w. Ponadto wykazano dodatni\u0105 korelacj\u0119 pomi\u0119dzy st\u0119\u017ceniem magnezu a nasileniem depresji mierzonym Skal\u0105 Depresji Hamiltona oraz skal\u0105 Montgomery-Asberg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>Uzyskane wyniki mog\u0105 sugerowa\u0107 rol\u0119 magnezu jako markera stanu, odzwierciedlaj\u0105cego  patofizjologiczne zmiany le\u017c\u0105ce u pod\u0142o\u017ca MDD i towarzysz\u0105ce ci\u0119\u017ckim epizodom depresyjnym.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/onlinefirst\/44137","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T01:10:17Z","timestamp":1433207417000},"page":"1265-1276","source":"Crossref","is-referenced-by-count":12,"title":["The serum magnesium concentration as a potential state marker in patients with unipolar affective disorder"],"prefix":"10.12740","volume":"49","author":[{"given":"Krzysztof","family":"Stycze\u0144","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Siwek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Sowa-Ku\u0107ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Witold","family":"Reczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadeta","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Misztak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Top\u00f3r-M\u0105dry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142odzimierz","family":"Opoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5036","published-online":{"date-parts":[[2015,12,31]]},"container-title":["Psychiatria Polska"],"original-title":["St\u0119\u017cenie magnezu w surowicy jako potencjalny marker stanu u chorych na depresj\u0119 jednobiegunow\u0105"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-58141-81234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-58141-81234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:59:32Z","timestamp":1666076372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Stezenie-magnezu-w-surowicy-jako-potencjalny-marker-stanu-u-chorych-na-depresje-jednobiegunowa,58141,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,31]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015]]}},"alternative-id":["58141"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/44137","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,31]]}}}