{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:13:44Z","timestamp":1791465224916,"version":"4.3.4"},"reference-count":0,"publisher":"Komitet Redakcyjno - Wydawniczy Polskiego Towarzystwa Psychiatrycznego","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatr Pol"],"published-print":{"date-parts":[[2017,6,18]]},"abstract":"<jats:sec><jats:title>Cel pracy<\/jats:title><jats:p>Nieliczne doniesienia naukowe wskazuj\u0105 na zmiany st\u0119\u017cenia miedzi w surowicy u os\u00f3b z chorob\u0105 afektywn\u0105 dwubiegunow\u0105 (ChAD), jednak dane te s\u0105 niejednoznaczne. Celem badania by\u0142o przeprowadzenie oceny st\u0119\u017ce\u0144 miedzi w surowicy krwi pacjent\u00f3w znajduj\u0105cych si\u0119 w r\u00f3\u017cnych fazach choroby dwubiegunowej w por\u00f3wnaniu do grupy zdrowych ochotnik\u00f3w, z uwzgl\u0119dnieniem specyficznych cech klinicznych oraz stopnia zaawansowania choroby.<\/jats:p><\/jats:sec><jats:sec><jats:title>Metoda<\/jats:title><jats:p>Do badania zakwalifikowano 133 pacjent\u00f3w z rozpoznaniem ChAD (typ I, II i BNO), w tym 61 os\u00f3b w epizodzie depresji, 23 osoby w stanie maniakalnym lub hipomaniakalnym i 49 pacjent\u00f3w w stanie remisji. Grupa kontrolna liczy\u0142a 50 os\u00f3b. Pomiaru st\u0119\u017cenia miedzi dokonano metod\u0105 atomowej spektrometrii absorpcyjnej.<\/jats:p><\/jats:sec><jats:sec><jats:title>Wyniki<\/jats:title><jats:p>Nie stwierdzono istotnych statystycznie r\u00f3\u017cnic w zakresie st\u0119\u017cenia miedzi w surowicy pomi\u0119dzy pacjentami znajduj\u0105cymi si\u0119 w poszczeg\u00f3lnych fazach ChAD (mania\/hipomania, depresja, remisja), z ro\u017cnymi podtypami ChAD (typ I, typ II+ BNO), czy te\u017c w r\u00f3\u017cnych stadiach zaawansowana choroby (staging), a grup\u0105 zdrowych ochotnik\u00f3w. St\u0119\u017cenie miedzi u pacjent\u00f3w znajduj\u0105cych si\u0119 w stadium 1 by\u0142o jednak istotnie statystycznie wy\u017csze w por\u00f3wnaniu do pozosta\u0142ych pacjent\u00f3w, znajduj\u0105cych si\u0119 w bardziej zaawansowanych fazach choroby (stadium 2+3+4), (\u03b2 =0,22; p=0,02). Ponadto st\u0119\u017cenie miedzi by\u0142o tym wy\u017csze im p\u00f3\u017aniejszy by\u0142 wiek zachorowania (\u03b2 =0,33; p&lt;0,001) oraz tym ni\u017csze im wi\u0119cej by\u0142o przebytych epizod\u00f3w choroby (\u03b2 =-0,23; p=0,02), (model regresji wielorakiej, adj R2=0,19, p=0,0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Wnioski<\/jats:title><jats:p>Przedstawione powy\u017cej zale\u017cno\u015bci mog\u0105 odzwierciedla\u0107 procesy patofizjologiczne zachodz\u0105ce w przebiegu ChAD (takie jak np. reakcja zapalna oraz stres oksydacyjny) i osi\u0105gaj\u0105ce r\u00f3\u017cn\u0105 intensywno\u015b\u0107 w zale\u017cno\u015bci od jej zaawansowania.<\/jats:p><\/jats:sec>","DOI":"10.12740\/pp\/onlinefirst\/65250","type":"journal-article","created":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T13:19:27Z","timestamp":1479043167000},"page":"469-481","source":"Crossref","is-referenced-by-count":24,"title":["The serum concentration of copper in bipolar disorder"],"prefix":"10.12740","volume":"51","author":[{"given":"Marcin","family":"Siwek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Stycze\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Sowa-Ku\u0107ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"Reczy\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadeta","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Misztak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142odzimierz","family":"Opoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Top\u00f3r-M\u0105dry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Rybakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5036","published-online":{"date-parts":[[2016,11,4]]},"container-title":["Psychiatria Polska"],"original-title":["St\u0119\u017cenie miedzi w surowicy w chorobie afektywnej dwubiegunowej"],"link":[{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-65250-81374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.psychiatriapolska.pl\/pdf-65250-81374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T06:57:06Z","timestamp":1666076226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.psychiatriapolska.pl\/Stezenie-miedzi-w-surowicy-w-chorobie-afektywnej-dwubiegunowej,65250,0,2.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"alternative-id":["65250"],"URL":"https:\/\/doi.org\/10.12740\/pp\/onlinefirst\/65250","relation":{},"ISSN":["0033-2674","2391-5854"],"issn-type":[{"value":"0033-2674","type":"print"},{"value":"2391-5854","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,4]]}}}