{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:15:57Z","timestamp":1764494157586,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["shmpublications.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hospital Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Gender\u2010related differences in COVID\u201019 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE\u2010COVID\u201019 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia\/anosmia. Laboratory tests in men presented alterations consistent with a more severe COVID\u201019 infection (eg, significantly higher C\u2010reactive protein, troponin, transaminases, lymphocytopenia, thrombocytopenia, and ferritin). Systemic inflammatory response syndrome, bilateral pneumonia, respiratory insufficiency, and renal failure were significantly more frequent in men. Men more often required pronation, corticosteroids, and tocilizumab administration. A significantly higher 30\u2010day mortality was observed in men vs women (23.4% vs 19.2%; <jats:italic>P<\/jats:italic> = .039). Trial Numbers: NCT04334291\/EUPAS34399.<\/jats:p>","DOI":"10.12788\/jhm.3594","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T10:48:24Z","timestamp":1622803704000},"page":"349-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID\u201019"],"prefix":"10.1002","volume":"16","author":[{"given":"Carloalberto","family":"Biol\u00e8","sequence":"first","affiliation":[{"name":"Division of Cardiology San Luigi Gonzaga University Hospital Orbassano (Turin) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Division of Cardiology San Luigi Gonzaga University Hospital Orbassano (Turin) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n J","family":"N\u00fa\u00f1ez\u2010Gil","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Division of Cardiology San Luigi Gonzaga University Hospital Orbassano (Turin) Italy"},{"name":"Interventional Cardiology Unit San Luigi Gonzaga University Hospital Orbassano, and Rivoli Infermi Hospital Rivoli (Turin) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Spirito","sequence":"additional","affiliation":[{"name":"Division of Cardiology San Luigi Gonzaga University Hospital Orbassano (Turin) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Raposeiras","family":"Roubin","sequence":"additional","affiliation":[{"name":"University Hospital \u00c1lvaro Cunqueiro Vigo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C","family":"Viana\u2010Llamas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Guadalajara Guadalajara Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infanta Sofia San Sebastian de los Reyes Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex F","family":"Castro\u2010Mej\u00eda","sequence":"additional","affiliation":[{"name":"Hospital General del norte de Guayaquil IESS Los Ceibos Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel Maroun","family":"Eid","sequence":"additional","affiliation":[{"name":"Hospital La Paz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fern\u00e1ndez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitor","family":"Uribarri","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Alfonso\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Cardiolog\u00eda y Cirug\u00eda Cardiovascular Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Ugo","sequence":"additional","affiliation":[{"name":"Sant'Andrea Hospital Vercelli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Guerra","sequence":"additional","affiliation":[{"name":"Cardiology and Arrhythmology Clinic Ospedali Riuniti \u201cUmberto I \u2010 Lancisi \u2010 Salesi\u201d Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Feltes","sequence":"additional","affiliation":[{"name":"Hospital Nuestra Se\u00f1ora de Am\u00e9rica Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"First Department of Medicine University Heidelberg Mannheim Germany"},{"name":"German Center for Cardiovascular Research Heidelberg\u2010Mannheim Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Fern\u00e1ndez\u2010Rozas","sequence":"additional","affiliation":[{"name":"Hospital Severo Ochoa Legan\u00e9s Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividad","family":"Blasco\u2010Angulo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria Incliva, Universidad de Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second People's Hospital of Shenzhen Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Garcia","family":"Aguado","sequence":"additional","affiliation":[{"name":"Hospital Puerta de Hierro Majadahonda Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martino","family":"Pepe","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Consorziale Policlinico di Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Romero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Getafe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor Manuel","family":"Becerra\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica \u00c1rea del Coraz\u00f3n Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA) Hospital Universitario Virgen de la Victoria Universidad de M\u00e1laga (UMA) Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Estrada","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Macaya","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.05.014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010020\u201000304\u20109"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2020.8472"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2020.4.47536"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2020.100654"},{"key":"e_1_2_7_7_1","unstructured":"International COVID\u201019 Clinical Evaluation Registry: HOPE\u2010COVID 19. Accessed February 6 2021.https:\/\/hopeprojectmd.com\/en\/"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010020\u20100276\u20101"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00206"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","unstructured":"PeckhamH deGruijterN RaineC et al.Sex\u2010bias in COVID\u201019: a meta\u2010analysis and review of sex differences in disease and immunity.Research Square.April 20 2020.https:\/\/doi.org\/10.21203\/rs.3.rs\u201023651\/v2","DOI":"10.21203\/rs.3.rs-23651\/v1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106159"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820934380"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2020.05.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201005965\u20101"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u20100348\u20108"}],"container-title":["Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/pdf\/10.12788\/jhm.3594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:26:59Z","timestamp":1760635619000},"score":1,"resource":{"primary":{"URL":"https:\/\/shmpublications.onlinelibrary.wiley.com\/doi\/10.12788\/jhm.3594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.12788\/jhm.3594"],"URL":"https:\/\/doi.org\/10.12788\/jhm.3594","archive":["Portico"],"relation":{},"ISSN":["1553-5592","1553-5606"],"issn-type":[{"type":"print","value":"1553-5592"},{"type":"electronic","value":"1553-5606"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"2020-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}