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This narrative review and the resulting implementation guide summarize published interventions to reduce inappropriate PPI use and provide a strategy for quality improvement teams.<\/jats:p>","DOI":"10.12788\/jhm.3637","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T15:25:22Z","timestamp":1625844322000},"source":"Crossref","is-referenced-by-count":11,"title":["Reducing Overuse of Proton Pump Inhibitors for Stress Ulcer Prophylaxis and Nonvariceal Gastrointestinal Bleeding in the Hospital: A Narrative Review and Implementation Guide"],"prefix":"10.1002","volume":"16","author":[{"given":"Karen","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimpal","family":"Bhakta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchita Shah","family":"Sata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarguni","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Pahwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Pherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Volpicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung J","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Savarino V, Marabotto E, Zentilin P, et al. Proton pump inhibitors: use and misuse in the clinical setting. Exp Rev Clin Pharmacol. 2018;11(11):1123-1134. https:\/\/doi.org\/10.1080\/17512433.2018.1531703","DOI":"10.1080\/17512433.2018.1531703"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Nardino RJ, Vender RJ, Herbert PN. Overuse of acid-suppressive therapy in hospitalized patients. Am J Gastroenterol. 2000;95(11):3118-3122. https:\/\/doi.org\/10.1111\/j.1572-0241.2000.03259.x","DOI":"10.1111\/j.1572-0241.2000.03259.x"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Ahrens D, Behrens G, Himmel W, Kochen MM, Chenot JF. Appropriateness of proton pump inhibitor recommendations at hospital discharge and continuation in primary care. Int J Clin Pract. 2012;66(8):767-773. https:\/\/doi.org\/10.1111\/j.1742-1241.2012.02973.x","DOI":"10.1111\/j.1742-1241.2012.02973.x"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Moledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. 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